node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASPRV1 | ELMOD3 | ENSP00000315383 | ENSP00000318264 | Retroviral-like aspartic protease 1; Gag like LTR retrotransposon derived genes | ELMO domain-containing protein 3; Acts as a GTPase-activating protein (GAP) for ARL2 with low specific activity; Deafness associated genes | 0.519 |
C2orf68 | ELMOD3 | ENSP00000304410 | ENSP00000318264 | UPF0561 protein C2orf68; Chromosome 2 open reading frame 68 | ELMO domain-containing protein 3; Acts as a GTPase-activating protein (GAP) for ARL2 with low specific activity; Deafness associated genes | 0.499 |
C2orf68 | SH2D6 | ENSP00000304410 | ENSP00000341867 | UPF0561 protein C2orf68; Chromosome 2 open reading frame 68 | SH2 domain containing 6 | 0.657 |
C2orf68 | TMEM150A | ENSP00000304410 | ENSP00000387292 | UPF0561 protein C2orf68; Chromosome 2 open reading frame 68 | Transmembrane protein 150A; Regulates localization of phosphatidylinositol 4-kinase (PI4K) to the plasma membrane, possibly by reducing the association of TTC7 (TTC7A or TTC7B) with the PI4K complex. Acts as a regulator of phosphatidylinositol 4- phosphate (PtdIns(4)P) synthesis. May also play a role in fasting-induced catabolism (By similarity) | 0.830 |
ELMO3 | ELMOD1 | ENSP00000377566 | ENSP00000265840 | Engulfment and cell motility protein 3; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity) | ELMO domain-containing protein 1; Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family | 0.446 |
ELMO3 | ELMOD3 | ENSP00000377566 | ENSP00000318264 | Engulfment and cell motility protein 3; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity) | ELMO domain-containing protein 3; Acts as a GTPase-activating protein (GAP) for ARL2 with low specific activity; Deafness associated genes | 0.452 |
ELMOD1 | ELMO3 | ENSP00000265840 | ENSP00000377566 | ELMO domain-containing protein 1; Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family | Engulfment and cell motility protein 3; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity) | 0.446 |
ELMOD1 | ELMOD3 | ENSP00000265840 | ENSP00000318264 | ELMO domain-containing protein 1; Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family | ELMO domain-containing protein 3; Acts as a GTPase-activating protein (GAP) for ARL2 with low specific activity; Deafness associated genes | 0.556 |
ELMOD3 | ASPRV1 | ENSP00000318264 | ENSP00000315383 | ELMO domain-containing protein 3; Acts as a GTPase-activating protein (GAP) for ARL2 with low specific activity; Deafness associated genes | Retroviral-like aspartic protease 1; Gag like LTR retrotransposon derived genes | 0.519 |
ELMOD3 | C2orf68 | ENSP00000318264 | ENSP00000304410 | ELMO domain-containing protein 3; Acts as a GTPase-activating protein (GAP) for ARL2 with low specific activity; Deafness associated genes | UPF0561 protein C2orf68; Chromosome 2 open reading frame 68 | 0.499 |
ELMOD3 | ELMO3 | ENSP00000318264 | ENSP00000377566 | ELMO domain-containing protein 3; Acts as a GTPase-activating protein (GAP) for ARL2 with low specific activity; Deafness associated genes | Engulfment and cell motility protein 3; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity) | 0.452 |
ELMOD3 | ELMOD1 | ENSP00000318264 | ENSP00000265840 | ELMO domain-containing protein 3; Acts as a GTPase-activating protein (GAP) for ARL2 with low specific activity; Deafness associated genes | ELMO domain-containing protein 1; Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family | 0.556 |
ELMOD3 | GLYATL3 | ENSP00000318264 | ENSP00000360240 | ELMO domain-containing protein 3; Acts as a GTPase-activating protein (GAP) for ARL2 with low specific activity; Deafness associated genes | Glycine N-acyltransferase-like protein 3; Acyltransferase which transfers the acyl group to the N- terminus of glycine | 0.536 |
ELMOD3 | GRXCR2 | ENSP00000318264 | ENSP00000367214 | ELMO domain-containing protein 3; Acts as a GTPase-activating protein (GAP) for ARL2 with low specific activity; Deafness associated genes | Glutaredoxin domain-containing cysteine-rich protein 2; Could play a role in maintaining cochlear stereocilia bundles that are involved in sound detection; Deafness associated genes | 0.473 |
ELMOD3 | RETSAT | ENSP00000318264 | ENSP00000295802 | ELMO domain-containing protein 3; Acts as a GTPase-activating protein (GAP) for ARL2 with low specific activity; Deafness associated genes | All-trans-retinol 13,14-reductase; Catalyzes the saturation of all-trans-retinol to all- trans-13,14-dihydroretinol. Does not exhibit any activity toward all-trans-retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers. May play a role in the metabolism of vitamin A. Independently of retinol conversion, may regulate liver metabolism upstream of MLXIPL/ChREBP. May play a role in adipocyte differentiation; Belongs to the carotenoid/retinoid oxidoreductase family. CrtISO subfamily | 0.472 |
ELMOD3 | SH2D6 | ENSP00000318264 | ENSP00000341867 | ELMO domain-containing protein 3; Acts as a GTPase-activating protein (GAP) for ARL2 with low specific activity; Deafness associated genes | SH2 domain containing 6 | 0.583 |
ELMOD3 | STPG1 | ENSP00000318264 | ENSP00000363530 | ELMO domain-containing protein 3; Acts as a GTPase-activating protein (GAP) for ARL2 with low specific activity; Deafness associated genes | O(6)-methylguanine-induced apoptosis 2; May positively contribute to the induction of apoptosis triggered by O(6)-methylguanine | 0.472 |
ELMOD3 | TMEM150A | ENSP00000318264 | ENSP00000387292 | ELMO domain-containing protein 3; Acts as a GTPase-activating protein (GAP) for ARL2 with low specific activity; Deafness associated genes | Transmembrane protein 150A; Regulates localization of phosphatidylinositol 4-kinase (PI4K) to the plasma membrane, possibly by reducing the association of TTC7 (TTC7A or TTC7B) with the PI4K complex. Acts as a regulator of phosphatidylinositol 4- phosphate (PtdIns(4)P) synthesis. May also play a role in fasting-induced catabolism (By similarity) | 0.489 |
GLYATL3 | ELMOD3 | ENSP00000360240 | ENSP00000318264 | Glycine N-acyltransferase-like protein 3; Acyltransferase which transfers the acyl group to the N- terminus of glycine | ELMO domain-containing protein 3; Acts as a GTPase-activating protein (GAP) for ARL2 with low specific activity; Deafness associated genes | 0.536 |
GRXCR2 | ELMOD3 | ENSP00000367214 | ENSP00000318264 | Glutaredoxin domain-containing cysteine-rich protein 2; Could play a role in maintaining cochlear stereocilia bundles that are involved in sound detection; Deafness associated genes | ELMO domain-containing protein 3; Acts as a GTPase-activating protein (GAP) for ARL2 with low specific activity; Deafness associated genes | 0.473 |