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  • 11.0 [archived version]
STRINGSTRING
SIVA1 SIVA1 PPP2R3B PPP2R3B ADARB2 ADARB2 CSRNP3 CSRNP3 TMEM65 TMEM65 RASEF RASEF BSDC1 BSDC1 TTC9 TTC9 ZSWIM4 ZSWIM4 C10orf10 C10orf10 TNFAIP6 TNFAIP6
"CSRNP3" - Cysteine/serine-rich nuclear protein 3 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CSRNP3Cysteine/serine-rich nuclear protein 3; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity. Plays a role in apoptosis (By similarity); Protein phosphatase 1 regulatory subunits (585 aa)    
Predicted Functional Partners:
BSDC1
BSD domain containing 1 (474 aa)
           
  0.712
PPP2R3B
Serine/threonine-protein phosphatase 2A regulatory subunit B’’ subunit beta; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment; EF-hand domain containing (575 aa)
           
  0.694
SIVA1
Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa- B and promotes T-cell receptor-mediated apoptosis (175 aa)
           
  0.685
TNFAIP6
Tumor necrosis factor-inducible gene 6 protein; Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis (277 aa)
           
  0.660
ADARB2
Double-stranded RNA-specific editase B2; Lacks editing activity. It prevents the binding of other ADAR enzymes to targets in vitro, and decreases the efficiency of these enzymes. Capable of binding to dsRNA but also to ssRNA; Adenosine deaminases acting on RNA (739 aa)
     
   
  0.635
TMEM65
Transmembrane protein 65; May play an important role in cardiac development and function. May regulate cardiac conduction and the function of the gap junction protein GJA1. May contributes to the stability and proper localization of GJA1 to cardiac intercalated disk thereby regulating gap junction communication (By similarity). May also play a role in the regulation of mitochondrial respiration and mitochondrial DNA copy number maintenance (240 aa)
           
  0.623
ZSWIM4
Zinc finger SWIM-type containing 4 (989 aa)
           
  0.608
C10orf10
Protein DEPP1; Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS (212 aa)
           
  0.587
TTC9
Tetratricopeptide repeat domain containing; Belongs to the TTC9 family (222 aa)
           
  0.574
RASEF
Ras and EF-hand domain-containing protein; Binds predominantly GDP, and also GTP; EF-hand domain containing (740 aa)
           
  0.556
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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