node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADARB2 | CSRNP3 | ENSP00000370713 | ENSP00000318258 | Double-stranded RNA-specific editase B2; Lacks editing activity. It prevents the binding of other ADAR enzymes to targets in vitro, and decreases the efficiency of these enzymes. Capable of binding to dsRNA but also to ssRNA; Adenosine deaminases acting on RNA | Cysteine/serine-rich nuclear protein 3; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity. Plays a role in apoptosis (By similarity); Protein phosphatase 1 regulatory subunits | 0.635 |
BSDC1 | CSRNP3 | ENSP00000344816 | ENSP00000318258 | BSD domain containing 1 | Cysteine/serine-rich nuclear protein 3; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity. Plays a role in apoptosis (By similarity); Protein phosphatase 1 regulatory subunits | 0.712 |
C10orf10 | CSRNP3 | ENSP00000298295 | ENSP00000318258 | Protein DEPP1; Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS | Cysteine/serine-rich nuclear protein 3; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity. Plays a role in apoptosis (By similarity); Protein phosphatase 1 regulatory subunits | 0.587 |
C10orf10 | RASEF | ENSP00000298295 | ENSP00000365630 | Protein DEPP1; Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS | Ras and EF-hand domain-containing protein; Binds predominantly GDP, and also GTP; EF-hand domain containing | 0.532 |
C10orf10 | TMEM65 | ENSP00000298295 | ENSP00000297632 | Protein DEPP1; Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS | Transmembrane protein 65; May play an important role in cardiac development and function. May regulate cardiac conduction and the function of the gap junction protein GJA1. May contributes to the stability and proper localization of GJA1 to cardiac intercalated disk thereby regulating gap junction communication (By similarity). May also play a role in the regulation of mitochondrial respiration and mitochondrial DNA copy number maintenance | 0.562 |
C10orf10 | TTC9 | ENSP00000298295 | ENSP00000256367 | Protein DEPP1; Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS | Tetratricopeptide repeat domain containing; Belongs to the TTC9 family | 0.559 |
C10orf10 | ZSWIM4 | ENSP00000298295 | ENSP00000254323 | Protein DEPP1; Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS | Zinc finger SWIM-type containing 4 | 0.588 |
CSRNP3 | ADARB2 | ENSP00000318258 | ENSP00000370713 | Cysteine/serine-rich nuclear protein 3; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity. Plays a role in apoptosis (By similarity); Protein phosphatase 1 regulatory subunits | Double-stranded RNA-specific editase B2; Lacks editing activity. It prevents the binding of other ADAR enzymes to targets in vitro, and decreases the efficiency of these enzymes. Capable of binding to dsRNA but also to ssRNA; Adenosine deaminases acting on RNA | 0.635 |
CSRNP3 | BSDC1 | ENSP00000318258 | ENSP00000344816 | Cysteine/serine-rich nuclear protein 3; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity. Plays a role in apoptosis (By similarity); Protein phosphatase 1 regulatory subunits | BSD domain containing 1 | 0.712 |
CSRNP3 | C10orf10 | ENSP00000318258 | ENSP00000298295 | Cysteine/serine-rich nuclear protein 3; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity. Plays a role in apoptosis (By similarity); Protein phosphatase 1 regulatory subunits | Protein DEPP1; Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS | 0.587 |
CSRNP3 | PPP2R3B | ENSP00000318258 | ENSP00000375080 | Cysteine/serine-rich nuclear protein 3; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity. Plays a role in apoptosis (By similarity); Protein phosphatase 1 regulatory subunits | Serine/threonine-protein phosphatase 2A regulatory subunit B’’ subunit beta; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment; EF-hand domain containing | 0.694 |
CSRNP3 | RASEF | ENSP00000318258 | ENSP00000365630 | Cysteine/serine-rich nuclear protein 3; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity. Plays a role in apoptosis (By similarity); Protein phosphatase 1 regulatory subunits | Ras and EF-hand domain-containing protein; Binds predominantly GDP, and also GTP; EF-hand domain containing | 0.556 |
CSRNP3 | SIVA1 | ENSP00000318258 | ENSP00000329213 | Cysteine/serine-rich nuclear protein 3; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity. Plays a role in apoptosis (By similarity); Protein phosphatase 1 regulatory subunits | Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa- B and promotes T-cell receptor-mediated apoptosis | 0.685 |
CSRNP3 | TMEM65 | ENSP00000318258 | ENSP00000297632 | Cysteine/serine-rich nuclear protein 3; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity. Plays a role in apoptosis (By similarity); Protein phosphatase 1 regulatory subunits | Transmembrane protein 65; May play an important role in cardiac development and function. May regulate cardiac conduction and the function of the gap junction protein GJA1. May contributes to the stability and proper localization of GJA1 to cardiac intercalated disk thereby regulating gap junction communication (By similarity). May also play a role in the regulation of mitochondrial respiration and mitochondrial DNA copy number maintenance | 0.623 |
CSRNP3 | TNFAIP6 | ENSP00000318258 | ENSP00000243347 | Cysteine/serine-rich nuclear protein 3; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity. Plays a role in apoptosis (By similarity); Protein phosphatase 1 regulatory subunits | Tumor necrosis factor-inducible gene 6 protein; Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis | 0.660 |
CSRNP3 | TTC9 | ENSP00000318258 | ENSP00000256367 | Cysteine/serine-rich nuclear protein 3; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity. Plays a role in apoptosis (By similarity); Protein phosphatase 1 regulatory subunits | Tetratricopeptide repeat domain containing; Belongs to the TTC9 family | 0.574 |
CSRNP3 | ZSWIM4 | ENSP00000318258 | ENSP00000254323 | Cysteine/serine-rich nuclear protein 3; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity. Plays a role in apoptosis (By similarity); Protein phosphatase 1 regulatory subunits | Zinc finger SWIM-type containing 4 | 0.608 |
PPP2R3B | CSRNP3 | ENSP00000375080 | ENSP00000318258 | Serine/threonine-protein phosphatase 2A regulatory subunit B’’ subunit beta; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment; EF-hand domain containing | Cysteine/serine-rich nuclear protein 3; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity. Plays a role in apoptosis (By similarity); Protein phosphatase 1 regulatory subunits | 0.694 |
RASEF | C10orf10 | ENSP00000365630 | ENSP00000298295 | Ras and EF-hand domain-containing protein; Binds predominantly GDP, and also GTP; EF-hand domain containing | Protein DEPP1; Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS | 0.532 |
RASEF | CSRNP3 | ENSP00000365630 | ENSP00000318258 | Ras and EF-hand domain-containing protein; Binds predominantly GDP, and also GTP; EF-hand domain containing | Cysteine/serine-rich nuclear protein 3; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity. Plays a role in apoptosis (By similarity); Protein phosphatase 1 regulatory subunits | 0.556 |