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STRINGSTRING
TTC5 TTC5 C19orf24 C19orf24 TPGS1 TPGS1 FLYWCH1 FLYWCH1 R3HDM4 R3HDM4 C2CD4C C2CD4C ODF3L2 ODF3L2 KIAA1586 KIAA1586 EGFR EGFR FAM76A FAM76A SMIM7 SMIM7
"ODF3L2" - Outer dense fiber of sperm tails 3 like 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ODF3L2Outer dense fiber of sperm tails 3 like 2 (289 aa)    
Predicted Functional Partners:
SMIM7
Small integral membrane protein 7 (103 aa)
            
  0.669
FAM76A
X-linked retinitis pigmentosa GTPase regulator-interacting protein 1; Family with sequence similarity 76 member A (341 aa)
            
  0.668
TTC5
Tetratricopeptide repeat protein 5; Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 (By similarity); Tetratricopeptide repeat domain containing (440 aa)
            
  0.598
TPGS1
Tubulin polyglutamylase complex subunit 1; May act in the targeting of the tubulin polyglutamylase complex. Required for the development of the spermatid flagellum (By similarity) (290 aa)
            
  0.589
R3HDM4
R3H domain containing 4 (268 aa)
            
  0.587
C2CD4C
C2 calcium-dependent domain-containing protein 4C; C2 calcium dependent domain containing 4C; Belongs to the C2CD4 family (421 aa)
      
   
  0.583
KIAA1586
E3 SUMO-protein ligase KIAA1586; E3 SUMO-protein ligase; facilitates UBE2I/UBC9-mediated SUMO2 modification of target proteins (787 aa)
            
  0.582
FLYWCH1
FLYWCH-type zinc finger 1 (715 aa)
            
  0.560
EGFR
Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates [...] (1210 aa)
        
 
  0.559
C19orf24
Uncharacterized membrane protein C19orf24; Chromosome 19 open reading frame 24 (132 aa)
            
  0.541
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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