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  • 11.0 [archived version]
STRINGSTRING
PECR PECR AMACR AMACR GNPAT GNPAT ACOT8 ACOT8 HAO1 HAO1 HAO2 HAO2 PIPOX PIPOX EHHADH EHHADH AGXT AGXT LONP2 LONP2 SARDH SARDH
"PIPOX" - Peroxisomal sarcosine oxidase in Homo sapiens
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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PIPOXPeroxisomal sarcosine oxidase; Metabolizes sarcosine, L-pipecolic acid and L-proline (390 aa)    
Predicted Functional Partners:
HAO2
Hydroxyacid oxidase 2; Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family (351 aa)
     
 
  0.985
AGXT
Alanine-glyoxylate aminotransferase (392 aa)
   
 
  0.983
HAO1
Hydroxyacid oxidase 1; Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2- hydroxy octanoate (370 aa)
     
 
  0.972
ACOT8
Acyl-coenzyme A thioesterase 8; Acyl-coenzyme A (acyl-CoA) thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Competes with bile acid CoA-amino acid N-acyltransferase (BAAT) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a preference for medium-length fatty acyl-CoAs (C2 to C20). Inactive towards substrates with more than C20 aliphatic chains. Involved in the metabolic regulation of peroxisome p [...] (319 aa)
         
  0.970
LONP2
Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1; AAA ATPases (852 aa)
     
 
  0.970
GNPAT
Glyceronephosphate O-acyltransferase (680 aa)
         
  0.969
PECR
Peroxisomal trans-2-enoyl-CoA reductase; Participates in chain elongation of fatty acids. Has no 2,4-dienoyl-CoA reductase activity; Short chain dehydrogenase/reductase superfamily (303 aa)
     
 
  0.964
EHHADH
Peroxisomal bifunctional enzyme; enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; In the C-terminal section; belongs to the 3- hydroxyacyl-CoA dehydrogenase family (723 aa)
     
 
  0.962
AMACR
Alpha-methylacyl-CoA racemase; Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers; Belongs to the CaiB/BaiF CoA-transferase family (394 aa)
     
 
  0.962
SARDH
Sarcosine dehydrogenase, mitochondrial; Sarcosine dehydrogenase; Belongs to the GcvT family (918 aa)
   
  0.960
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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