node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMER3 | GNPNAT1 | ENSP00000392700 | ENSP00000216410 | APC membrane recruitment protein 3; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity) | Glucosamine-phosphate N-acetyltransferase 1; Belongs to the acetyltransferase family. GNA1 subfamily | 0.539 |
AMER3 | HLTF | ENSP00000392700 | ENSP00000308944 | APC membrane recruitment protein 3; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity) | Helicase-like transcription factor; Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for ’Lys-63’-linked polyubiquitination of chromatin-bound PC [...] | 0.435 |
AMER3 | ZNF518B | ENSP00000392700 | ENSP00000317614 | APC membrane recruitment protein 3; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity) | Zinc finger protein 518B; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.629 |
FAM114A1 | PHTF2 | ENSP00000351740 | ENSP00000403042 | Protein NOXP20; May play a role in neuronal cell development; Belongs to the FAM114 family | Putative homeodomain transcription factor 2; May play a role in transcription regulation | 0.473 |
FAM114A1 | ZBTB26 | ENSP00000351740 | ENSP00000362760 | Protein NOXP20; May play a role in neuronal cell development; Belongs to the FAM114 family | Zinc finger and BTB domain-containing protein 26; May be involved in transcriptional regulation; BTB domain containing | 0.472 |
FAM114A1 | ZNF518B | ENSP00000351740 | ENSP00000317614 | Protein NOXP20; May play a role in neuronal cell development; Belongs to the FAM114 family | Zinc finger protein 518B; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.490 |
GNPNAT1 | AMER3 | ENSP00000216410 | ENSP00000392700 | Glucosamine-phosphate N-acetyltransferase 1; Belongs to the acetyltransferase family. GNA1 subfamily | APC membrane recruitment protein 3; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity) | 0.539 |
GNPNAT1 | ZNF518B | ENSP00000216410 | ENSP00000317614 | Glucosamine-phosphate N-acetyltransferase 1; Belongs to the acetyltransferase family. GNA1 subfamily | Zinc finger protein 518B; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.664 |
HLTF | AMER3 | ENSP00000308944 | ENSP00000392700 | Helicase-like transcription factor; Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for ’Lys-63’-linked polyubiquitination of chromatin-bound PC [...] | APC membrane recruitment protein 3; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity) | 0.435 |
HLTF | ZNF518B | ENSP00000308944 | ENSP00000317614 | Helicase-like transcription factor; Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for ’Lys-63’-linked polyubiquitination of chromatin-bound PC [...] | Zinc finger protein 518B; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.500 |
PHTF2 | FAM114A1 | ENSP00000403042 | ENSP00000351740 | Putative homeodomain transcription factor 2; May play a role in transcription regulation | Protein NOXP20; May play a role in neuronal cell development; Belongs to the FAM114 family | 0.473 |
PHTF2 | ZBTB26 | ENSP00000403042 | ENSP00000362760 | Putative homeodomain transcription factor 2; May play a role in transcription regulation | Zinc finger and BTB domain-containing protein 26; May be involved in transcriptional regulation; BTB domain containing | 0.440 |
PHTF2 | ZNF518B | ENSP00000403042 | ENSP00000317614 | Putative homeodomain transcription factor 2; May play a role in transcription regulation | Zinc finger protein 518B; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.492 |
SLC25A15 | ZNF518B | ENSP00000342267 | ENSP00000317614 | Mitochondrial ornithine transporter 1; Ornithine transport across inner mitochondrial membrane, from the cytoplasm to the matrix; Solute carriers | Zinc finger protein 518B; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.522 |
SLC2A9 | WDR1 | ENSP00000264784 | ENSP00000427687 | Solute carrier family 2, facilitated glucose transporter member 9; Transport urate and fructose. May have a role in the urate reabsorption by proximal tubules. Also transports glucose at low rate; Solute carriers | WD repeat-containing protein 1; Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions. Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape chan [...] | 0.573 |
SLC2A9 | ZNF518B | ENSP00000264784 | ENSP00000317614 | Solute carrier family 2, facilitated glucose transporter member 9; Transport urate and fructose. May have a role in the urate reabsorption by proximal tubules. Also transports glucose at low rate; Solute carriers | Zinc finger protein 518B; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.542 |
TBC1D9B | ZNF518B | ENSP00000349291 | ENSP00000317614 | TBC1 domain family member 9B; May act as a GTPase-activating protein for Rab family protein(s); EF-hand domain containing | Zinc finger protein 518B; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.533 |
WDR1 | SLC2A9 | ENSP00000427687 | ENSP00000264784 | WD repeat-containing protein 1; Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions. Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape chan [...] | Solute carrier family 2, facilitated glucose transporter member 9; Transport urate and fructose. May have a role in the urate reabsorption by proximal tubules. Also transports glucose at low rate; Solute carriers | 0.573 |
WDR1 | ZNF518B | ENSP00000427687 | ENSP00000317614 | WD repeat-containing protein 1; Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions. Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape chan [...] | Zinc finger protein 518B; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.557 |
ZBTB26 | FAM114A1 | ENSP00000362760 | ENSP00000351740 | Zinc finger and BTB domain-containing protein 26; May be involved in transcriptional regulation; BTB domain containing | Protein NOXP20; May play a role in neuronal cell development; Belongs to the FAM114 family | 0.472 |