PCNXL4 protein (human) - STRING database

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PCNXL4

Pecanex-like 4 (Drosophila); Belongs to the pecanex family (938 aa)

Predicted Functional Partners:

CSDE1

0.569

SLC35A4

0.537

CCNI

0.526

RPL12

0.503

C19orf48

0.470

PTP4A1

0.448

PPP1R15B

0.448

HOXB2

0.436

MCTS1

0.431

IFRD1

0.429

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C19orf48	PCNXL4	ENSP00000471463	ENSP00000317396	Uncharacterized protein C19orf48; Chromosome 19 open reading frame 48; Minor histocompatibility antigens	Pecanex-like 4 (Drosophila); Belongs to the pecanex family	0.470
CCNI	PCNXL4	ENSP00000237654	ENSP00000317396	Cyclin-I; Cyclin I; Belongs to the cyclin family	Pecanex-like 4 (Drosophila); Belongs to the pecanex family	0.526
CSDE1	PCNXL4	ENSP00000481762	ENSP00000317396	Cold shock domain-containing protein E1; RNA-binding protein. Required for internal initiation of translation of human rhinovirus RNA. May be involved in translationally coupled mRNA turnover. Implicated with other RNA- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding- region determinant of instability (mCRD) domain	Pecanex-like 4 (Drosophila); Belongs to the pecanex family	0.569
HOXB2	PCNXL4	ENSP00000331741	ENSP00000317396	Homeobox protein Hox-B2; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. Proboscipedia subfamily	Pecanex-like 4 (Drosophila); Belongs to the pecanex family	0.436
IFRD1	PCNXL4	ENSP00000384477	ENSP00000317396	Interferon-related developmental regulator 1; Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand-induced signal (By similarity); Belongs to the IFRD family	Pecanex-like 4 (Drosophila); Belongs to the pecanex family	0.429
MCTS1	PCNXL4	ENSP00000360365	ENSP00000317396	Malignant T-cell-amplified sequence 1; Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constitutively expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated diss [...]	Pecanex-like 4 (Drosophila); Belongs to the pecanex family	0.431
PCNXL4	C19orf48	ENSP00000317396	ENSP00000471463	Pecanex-like 4 (Drosophila); Belongs to the pecanex family	Uncharacterized protein C19orf48; Chromosome 19 open reading frame 48; Minor histocompatibility antigens	0.470
PCNXL4	CCNI	ENSP00000317396	ENSP00000237654	Pecanex-like 4 (Drosophila); Belongs to the pecanex family	Cyclin-I; Cyclin I; Belongs to the cyclin family	0.526
PCNXL4	CSDE1	ENSP00000317396	ENSP00000481762	Pecanex-like 4 (Drosophila); Belongs to the pecanex family	Cold shock domain-containing protein E1; RNA-binding protein. Required for internal initiation of translation of human rhinovirus RNA. May be involved in translationally coupled mRNA turnover. Implicated with other RNA- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding- region determinant of instability (mCRD) domain	0.569
PCNXL4	HOXB2	ENSP00000317396	ENSP00000331741	Pecanex-like 4 (Drosophila); Belongs to the pecanex family	Homeobox protein Hox-B2; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. Proboscipedia subfamily	0.436
PCNXL4	IFRD1	ENSP00000317396	ENSP00000384477	Pecanex-like 4 (Drosophila); Belongs to the pecanex family	Interferon-related developmental regulator 1; Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand-induced signal (By similarity); Belongs to the IFRD family	0.429
PCNXL4	MCTS1	ENSP00000317396	ENSP00000360365	Pecanex-like 4 (Drosophila); Belongs to the pecanex family	Malignant T-cell-amplified sequence 1; Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constitutively expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated diss [...]	0.431
PCNXL4	PPP1R15B	ENSP00000317396	ENSP00000356156	Pecanex-like 4 (Drosophila); Belongs to the pecanex family	Protein phosphatase 1 regulatory subunit 15B; Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1; Belongs to the PPP1R15 family	0.448
PCNXL4	PTP4A1	ENSP00000317396	ENSP00000359685	Pecanex-like 4 (Drosophila); Belongs to the pecanex family	Protein tyrosine phosphatase type IVA 1; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis	0.448
PCNXL4	RPL12	ENSP00000317396	ENSP00000354739	Pecanex-like 4 (Drosophila); Belongs to the pecanex family	60S ribosomal protein L12; Binds directly to 26S ribosomal RNA	0.503
PCNXL4	SLC35A4	ENSP00000317396	ENSP00000424566	Pecanex-like 4 (Drosophila); Belongs to the pecanex family	Probable UDP-sugar transporter protein SLC35A4; Solute carrier family 35 member A4; Belongs to the nucleotide-sugar transporter family. SLC35A subfamily	0.537
PPP1R15B	PCNXL4	ENSP00000356156	ENSP00000317396	Protein phosphatase 1 regulatory subunit 15B; Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1; Belongs to the PPP1R15 family	Pecanex-like 4 (Drosophila); Belongs to the pecanex family	0.448
PTP4A1	PCNXL4	ENSP00000359685	ENSP00000317396	Protein tyrosine phosphatase type IVA 1; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis	Pecanex-like 4 (Drosophila); Belongs to the pecanex family	0.448
RPL12	PCNXL4	ENSP00000354739	ENSP00000317396	60S ribosomal protein L12; Binds directly to 26S ribosomal RNA	Pecanex-like 4 (Drosophila); Belongs to the pecanex family	0.503
SLC35A4	PCNXL4	ENSP00000424566	ENSP00000317396	Probable UDP-sugar transporter protein SLC35A4; Solute carrier family 35 member A4; Belongs to the nucleotide-sugar transporter family. SLC35A subfamily	Pecanex-like 4 (Drosophila); Belongs to the pecanex family	0.537

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