| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANO4 | SLC17A8 | ENSP00000376703 | ENSP00000316909 | Anoctamin-4; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium-activated chloride channel (CaCC) activity; Belongs to the anoctamin family | Vesicular glutamate transporter 3; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate; Deafness associated genes | 0.801 |
| FAM19A4 | SLC17A8 | ENSP00000295569 | ENSP00000316909 | Protein FAM19A4; Family with sequence similarity 19 member A4, C-C motif chemokine like | Vesicular glutamate transporter 3; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate; Deafness associated genes | 0.789 |
| OTOF | SLC17A8 | ENSP00000272371 | ENSP00000316909 | Otoferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion and in the control of neurotransmitter release at these output synapses. Interacts in a calcium-dependent manner to the presynaptic SNARE proteins at ribbon synapses of cochlear inner hair cells (IHCs) to trigger exocytosis of neurotransmitter. Also essential to synaptic exocytosis in immature outer hair cells (OHCs). May also play a role within the recycling of endosomes (By similarity); Deafness associated genes | Vesicular glutamate transporter 3; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate; Deafness associated genes | 0.754 |
| SLC17A6 | SLC17A7 | ENSP00000263160 | ENSP00000221485 | Vesicular glutamate transporter 2; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate; Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily | Vesicular glutamate transporter 1; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate; Solute carriers | 0.838 |
| SLC17A6 | SLC17A8 | ENSP00000263160 | ENSP00000316909 | Vesicular glutamate transporter 2; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate; Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily | Vesicular glutamate transporter 3; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate; Deafness associated genes | 0.811 |
| SLC17A6 | SLC18A1 | ENSP00000263160 | ENSP00000387549 | Vesicular glutamate transporter 2; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate; Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily | Chromaffin granule amine transporter; Involved in the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles of neuroendocrine and endocrine cells; Belongs to the major facilitator superfamily. Vesicular transporter family | 0.882 |
| SLC17A6 | SLC18A2 | ENSP00000263160 | ENSP00000298472 | Vesicular glutamate transporter 2; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate; Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily | Synaptic vesicular amine transporter; Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis; Belongs to the major facilitator superfamily. Vesicular transporter family | 0.919 |
| SLC17A6 | SLC18A3 | ENSP00000263160 | ENSP00000363229 | Vesicular glutamate transporter 2; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate; Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily | Vesicular acetylcholine transporter; Involved in acetylcholine transport into synaptic vesicles; Solute carriers | 0.958 |
| SLC17A6 | SLC32A1 | ENSP00000263160 | ENSP00000217420 | Vesicular glutamate transporter 2; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate; Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily | Vesicular inhibitory amino acid transporter; Involved in the uptake of GABA and glycine into the synaptic vesicles; Solute carriers | 0.987 |
| SLC17A7 | SLC17A6 | ENSP00000221485 | ENSP00000263160 | Vesicular glutamate transporter 1; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate; Solute carriers | Vesicular glutamate transporter 2; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate; Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily | 0.838 |
| SLC17A7 | SLC17A8 | ENSP00000221485 | ENSP00000316909 | Vesicular glutamate transporter 1; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate; Solute carriers | Vesicular glutamate transporter 3; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate; Deafness associated genes | 0.806 |
| SLC17A7 | SLC18A1 | ENSP00000221485 | ENSP00000387549 | Vesicular glutamate transporter 1; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate; Solute carriers | Chromaffin granule amine transporter; Involved in the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles of neuroendocrine and endocrine cells; Belongs to the major facilitator superfamily. Vesicular transporter family | 0.875 |
| SLC17A7 | SLC18A2 | ENSP00000221485 | ENSP00000298472 | Vesicular glutamate transporter 1; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate; Solute carriers | Synaptic vesicular amine transporter; Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis; Belongs to the major facilitator superfamily. Vesicular transporter family | 0.914 |
| SLC17A7 | SLC18A3 | ENSP00000221485 | ENSP00000363229 | Vesicular glutamate transporter 1; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate; Solute carriers | Vesicular acetylcholine transporter; Involved in acetylcholine transport into synaptic vesicles; Solute carriers | 0.958 |
| SLC17A7 | SLC32A1 | ENSP00000221485 | ENSP00000217420 | Vesicular glutamate transporter 1; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate; Solute carriers | Vesicular inhibitory amino acid transporter; Involved in the uptake of GABA and glycine into the synaptic vesicles; Solute carriers | 0.988 |
| SLC17A7 | SYNPR | ENSP00000221485 | ENSP00000418994 | Vesicular glutamate transporter 1; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate; Solute carriers | Synaptoporin; Intrinsic membrane protein of small synaptic vesicles. Probable vesicular channel protein (By similarity); Belongs to the synaptophysin/synaptobrevin family | 0.603 |
| SLC17A8 | ANO4 | ENSP00000316909 | ENSP00000376703 | Vesicular glutamate transporter 3; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate; Deafness associated genes | Anoctamin-4; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium-activated chloride channel (CaCC) activity; Belongs to the anoctamin family | 0.801 |
| SLC17A8 | FAM19A4 | ENSP00000316909 | ENSP00000295569 | Vesicular glutamate transporter 3; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate; Deafness associated genes | Protein FAM19A4; Family with sequence similarity 19 member A4, C-C motif chemokine like | 0.789 |
| SLC17A8 | OTOF | ENSP00000316909 | ENSP00000272371 | Vesicular glutamate transporter 3; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate; Deafness associated genes | Otoferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion and in the control of neurotransmitter release at these output synapses. Interacts in a calcium-dependent manner to the presynaptic SNARE proteins at ribbon synapses of cochlear inner hair cells (IHCs) to trigger exocytosis of neurotransmitter. Also essential to synaptic exocytosis in immature outer hair cells (OHCs). May also play a role within the recycling of endosomes (By similarity); Deafness associated genes | 0.754 |
| SLC17A8 | SLC17A6 | ENSP00000316909 | ENSP00000263160 | Vesicular glutamate transporter 3; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate; Deafness associated genes | Vesicular glutamate transporter 2; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate; Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily | 0.811 |
