| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANKRD50 | ARL9 | ENSP00000425658 | ENSP00000353210 | Ankyrin repeat domain-containing protein 50; Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1; Ankyrin repeat domain containing | ADP-ribosylation factor-like protein 9; ADP ribosylation factor like GTPase 9; ARF GTPase family | 0.735 |
| ANKRD50 | LIMCH1 | ENSP00000425658 | ENSP00000316891 | Ankyrin repeat domain-containing protein 50; Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1; Ankyrin repeat domain containing | LIM and calponin homology domains 1 | 0.648 |
| ANKRD50 | TAPT1 | ENSP00000425658 | ENSP00000385347 | Ankyrin repeat domain-containing protein 50; Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1; Ankyrin repeat domain containing | Transmembrane anterior posterior transformation protein 1 homolog; Plays a role in primary cilia formation. May act as a downstream effector of HOXC8 possibly by transducing or transmitting extracellular information required for axial skeletal patterning during development (By similarity). May be involved in cartilage and bone development (By similarity). May play a role in the differentiation of cranial neural crest cells (By similarity) | 0.628 |
| ANKRD50 | TMEM33 | ENSP00000425658 | ENSP00000422473 | Ankyrin repeat domain-containing protein 50; Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1; Ankyrin repeat domain containing | Transmembrane protein 33; Acts as a regulator of the tubular endoplasmic reticulum (ER) network. Suppresses the RTN3/4-induced formation of the ER tubules. Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling | 0.739 |
| ARL9 | ANKRD50 | ENSP00000353210 | ENSP00000425658 | ADP-ribosylation factor-like protein 9; ADP ribosylation factor like GTPase 9; ARF GTPase family | Ankyrin repeat domain-containing protein 50; Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1; Ankyrin repeat domain containing | 0.735 |
| ARL9 | LIMCH1 | ENSP00000353210 | ENSP00000316891 | ADP-ribosylation factor-like protein 9; ADP ribosylation factor like GTPase 9; ARF GTPase family | LIM and calponin homology domains 1 | 0.599 |
| ARL9 | TAPT1 | ENSP00000353210 | ENSP00000385347 | ADP-ribosylation factor-like protein 9; ADP ribosylation factor like GTPase 9; ARF GTPase family | Transmembrane anterior posterior transformation protein 1 homolog; Plays a role in primary cilia formation. May act as a downstream effector of HOXC8 possibly by transducing or transmitting extracellular information required for axial skeletal patterning during development (By similarity). May be involved in cartilage and bone development (By similarity). May play a role in the differentiation of cranial neural crest cells (By similarity) | 0.602 |
| ARL9 | TMEM33 | ENSP00000353210 | ENSP00000422473 | ADP-ribosylation factor-like protein 9; ADP ribosylation factor like GTPase 9; ARF GTPase family | Transmembrane protein 33; Acts as a regulator of the tubular endoplasmic reticulum (ER) network. Suppresses the RTN3/4-induced formation of the ER tubules. Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling | 0.728 |
| C8orf59 | EPS8L2 | ENSP00000484492 | ENSP00000435585 | Uncharacterized protein C8orf59; Chromosome 8 open reading frame 59 | Epidermal growth factor receptor kinase substrate 8-like protein 2; Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity); Belongs to the EPS8 family | 0.755 |
| C8orf59 | HDHD1 | ENSP00000484492 | ENSP00000396452 | Uncharacterized protein C8orf59; Chromosome 8 open reading frame 59 | Pseudouridine-5’-phosphatase; Dephosphorylates pseudouridine 5’-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine; Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family | 0.439 |
| C8orf59 | LIMCH1 | ENSP00000484492 | ENSP00000316891 | Uncharacterized protein C8orf59; Chromosome 8 open reading frame 59 | LIM and calponin homology domains 1 | 0.618 |
| EPS8L2 | C8orf59 | ENSP00000435585 | ENSP00000484492 | Epidermal growth factor receptor kinase substrate 8-like protein 2; Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity); Belongs to the EPS8 family | Uncharacterized protein C8orf59; Chromosome 8 open reading frame 59 | 0.755 |
| EPS8L2 | HDHD1 | ENSP00000435585 | ENSP00000396452 | Epidermal growth factor receptor kinase substrate 8-like protein 2; Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity); Belongs to the EPS8 family | Pseudouridine-5’-phosphatase; Dephosphorylates pseudouridine 5’-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine; Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family | 0.416 |
| EPS8L2 | LIMCH1 | ENSP00000435585 | ENSP00000316891 | Epidermal growth factor receptor kinase substrate 8-like protein 2; Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity); Belongs to the EPS8 family | LIM and calponin homology domains 1 | 0.563 |
| FHL2 | LIMCH1 | ENSP00000386665 | ENSP00000316891 | Four and a half LIM domains protein 2; May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation; LIM domain containing | LIM and calponin homology domains 1 | 0.583 |
| HDHD1 | C8orf59 | ENSP00000396452 | ENSP00000484492 | Pseudouridine-5’-phosphatase; Dephosphorylates pseudouridine 5’-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine; Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family | Uncharacterized protein C8orf59; Chromosome 8 open reading frame 59 | 0.439 |
| HDHD1 | EPS8L2 | ENSP00000396452 | ENSP00000435585 | Pseudouridine-5’-phosphatase; Dephosphorylates pseudouridine 5’-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine; Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family | Epidermal growth factor receptor kinase substrate 8-like protein 2; Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity); Belongs to the EPS8 family | 0.416 |
| HDHD1 | LIMCH1 | ENSP00000396452 | ENSP00000316891 | Pseudouridine-5’-phosphatase; Dephosphorylates pseudouridine 5’-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine; Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family | LIM and calponin homology domains 1 | 0.552 |
| LIMCH1 | ANKRD50 | ENSP00000316891 | ENSP00000425658 | LIM and calponin homology domains 1 | Ankyrin repeat domain-containing protein 50; Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1; Ankyrin repeat domain containing | 0.648 |
| LIMCH1 | ARL9 | ENSP00000316891 | ENSP00000353210 | LIM and calponin homology domains 1 | ADP-ribosylation factor-like protein 9; ADP ribosylation factor like GTPase 9; ARF GTPase family | 0.599 |
