node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACAA1 | PEX1 | ENSP00000333664 | ENSP00000248633 | 3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1 | Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | 0.658 |
ACAA1 | PEX10 | ENSP00000333664 | ENSP00000288774 | 3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins | 0.955 |
ACAA1 | PEX12 | ENSP00000333664 | ENSP00000482609 | 3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1 | Peroxisome assembly protein 12; Required for protein import into peroxisomes; Peroxins | 0.924 |
ACAA1 | PEX13 | ENSP00000333664 | ENSP00000295030 | 3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1 | Peroxisomal membrane protein PEX13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins; Peroxins | 0.960 |
ACAA1 | PEX14 | ENSP00000333664 | ENSP00000349016 | 3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1 | Peroxisomal membrane protein PEX14; Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PEX5). Plays a key role for peroxisome movement through a direct interaction with tubulin; Peroxins | 0.960 |
ACAA1 | PEX2 | ENSP00000333664 | ENSP00000349543 | 3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1 | Peroxisome biogenesis factor 2; Somewhat implicated in the biogenesis of peroxisomes; Belongs to the pex2/pex10/pex12 family | 0.928 |
ACAA1 | PEX5 | ENSP00000333664 | ENSP00000391601 | 3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1 | Peroxisomal targeting signal 1 receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import | 0.856 |
ACAA1 | PEX5L | ENSP00000333664 | ENSP00000419975 | 3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1 | PEX5-related protein; Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence; Belongs to the peroxisomal targeting signal receptor family | 0.592 |
ACAA1 | PEX6 | ENSP00000333664 | ENSP00000303511 | 3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1 | Peroxisome assembly factor 2; Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | 0.513 |
ACAA1 | PEX7 | ENSP00000333664 | ENSP00000315680 | 3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1 | Peroxisomal targeting signal 2 receptor; Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import; Belongs to the WD repeat peroxin-7 family | 0.993 |
PEX1 | ACAA1 | ENSP00000248633 | ENSP00000333664 | Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | 3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1 | 0.658 |
PEX1 | PEX10 | ENSP00000248633 | ENSP00000288774 | Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins | 0.991 |
PEX1 | PEX12 | ENSP00000248633 | ENSP00000482609 | Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | Peroxisome assembly protein 12; Required for protein import into peroxisomes; Peroxins | 0.993 |
PEX1 | PEX13 | ENSP00000248633 | ENSP00000295030 | Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | Peroxisomal membrane protein PEX13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins; Peroxins | 0.993 |
PEX1 | PEX14 | ENSP00000248633 | ENSP00000349016 | Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | Peroxisomal membrane protein PEX14; Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PEX5). Plays a key role for peroxisome movement through a direct interaction with tubulin; Peroxins | 0.985 |
PEX1 | PEX2 | ENSP00000248633 | ENSP00000349543 | Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | Peroxisome biogenesis factor 2; Somewhat implicated in the biogenesis of peroxisomes; Belongs to the pex2/pex10/pex12 family | 0.988 |
PEX1 | PEX5 | ENSP00000248633 | ENSP00000391601 | Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | Peroxisomal targeting signal 1 receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import | 0.920 |
PEX1 | PEX5L | ENSP00000248633 | ENSP00000419975 | Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | PEX5-related protein; Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence; Belongs to the peroxisomal targeting signal receptor family | 0.825 |
PEX1 | PEX6 | ENSP00000248633 | ENSP00000303511 | Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | Peroxisome assembly factor 2; Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | 0.982 |
PEX1 | PEX7 | ENSP00000248633 | ENSP00000315680 | Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | Peroxisomal targeting signal 2 receptor; Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import; Belongs to the WD repeat peroxin-7 family | 0.987 |