node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AVL9 | DENND6A | ENSP00000315568 | ENSP00000311401 | Late secretory pathway protein AVL9 homolog; Functions in cell migration | Protein DENND6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes; DENN/MADD domain containing | 0.905 |
AVL9 | DENND6B | ENSP00000315568 | ENSP00000391524 | Late secretory pathway protein AVL9 homolog; Functions in cell migration | Protein DENND6B; Guanine nucleotide exchange factor (GEF) for RAB14. Also has some, lesser GEF activity towards RAB35; DENN/MADD domain containing | 0.622 |
AVL9 | DNM1L | ENSP00000315568 | ENSP00000449089 | Late secretory pathway protein AVL9 homolog; Functions in cell migration | Dynamin-1-like protein; Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane- associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptos [...] | 0.816 |
AVL9 | FAM45A | ENSP00000315568 | ENSP00000354688 | Late secretory pathway protein AVL9 homolog; Functions in cell migration | Protein FAM45A; Family with sequence similarity 45 member A | 0.905 |
AVL9 | KBTBD2 | ENSP00000315568 | ENSP00000302586 | Late secretory pathway protein AVL9 homolog; Functions in cell migration | Kelch repeat and BTB domain containing 2 | 0.778 |
AVL9 | KIAA1147 | ENSP00000315568 | ENSP00000445768 | Late secretory pathway protein AVL9 homolog; Functions in cell migration | Protein LCHN; May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia | 0.925 |
AVL9 | RIC1 | ENSP00000315568 | ENSP00000416696 | Late secretory pathway protein AVL9 homolog; Functions in cell migration | RAB6A-GEF complex partner protein 1; The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1- RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1; WD repeat domain containing | 0.633 |
AVL9 | RNF152 | ENSP00000315568 | ENSP00000316628 | Late secretory pathway protein AVL9 homolog; Functions in cell migration | E3 ubiquitin-protein ligase RNF152; E3 ubiquitin-protein ligase mediating ’Lys-63’-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability. Also mediates ’Lys-48’-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed; Ring finger proteins | 0.724 |
AVL9 | RNF31 | ENSP00000315568 | ENSP00000315112 | Late secretory pathway protein AVL9 homolog; Functions in cell migration | E3 ubiquitin-protein ligase RNF31; E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear (’Met-1’-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF- [...] | 0.681 |
AVL9 | SNAPC4 | ENSP00000315568 | ENSP00000298532 | Late secretory pathway protein AVL9 homolog; Functions in cell migration | snRNA-activating protein complex subunit 4; Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box; Myb/SANT domain containing | 0.713 |
DENND6A | AVL9 | ENSP00000311401 | ENSP00000315568 | Protein DENND6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes; DENN/MADD domain containing | Late secretory pathway protein AVL9 homolog; Functions in cell migration | 0.905 |
DENND6A | DNM1L | ENSP00000311401 | ENSP00000449089 | Protein DENND6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes; DENN/MADD domain containing | Dynamin-1-like protein; Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane- associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptos [...] | 0.402 |
DENND6A | FAM45A | ENSP00000311401 | ENSP00000354688 | Protein DENND6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes; DENN/MADD domain containing | Protein FAM45A; Family with sequence similarity 45 member A | 0.909 |
DENND6A | KIAA1147 | ENSP00000311401 | ENSP00000445768 | Protein DENND6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes; DENN/MADD domain containing | Protein LCHN; May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia | 0.907 |
DENND6B | AVL9 | ENSP00000391524 | ENSP00000315568 | Protein DENND6B; Guanine nucleotide exchange factor (GEF) for RAB14. Also has some, lesser GEF activity towards RAB35; DENN/MADD domain containing | Late secretory pathway protein AVL9 homolog; Functions in cell migration | 0.622 |
DENND6B | FAM45A | ENSP00000391524 | ENSP00000354688 | Protein DENND6B; Guanine nucleotide exchange factor (GEF) for RAB14. Also has some, lesser GEF activity towards RAB35; DENN/MADD domain containing | Protein FAM45A; Family with sequence similarity 45 member A | 0.743 |
DENND6B | KIAA1147 | ENSP00000391524 | ENSP00000445768 | Protein DENND6B; Guanine nucleotide exchange factor (GEF) for RAB14. Also has some, lesser GEF activity towards RAB35; DENN/MADD domain containing | Protein LCHN; May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia | 0.710 |
DNM1L | AVL9 | ENSP00000449089 | ENSP00000315568 | Dynamin-1-like protein; Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane- associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptos [...] | Late secretory pathway protein AVL9 homolog; Functions in cell migration | 0.816 |
DNM1L | DENND6A | ENSP00000449089 | ENSP00000311401 | Dynamin-1-like protein; Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane- associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptos [...] | Protein DENND6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes; DENN/MADD domain containing | 0.402 |
DNM1L | FAM45A | ENSP00000449089 | ENSP00000354688 | Dynamin-1-like protein; Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane- associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptos [...] | Protein FAM45A; Family with sequence similarity 45 member A | 0.545 |