C2orf57 protein (human) - STRING database

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C2orf57

Testis-expressed protein 44; Chromosome 2 open reading frame 57 (395 aa)

Predicted Functional Partners:

TEX37

0.839

MPC2

0.794

TIMM17B

0.766

C19orf70

0.747

DNAH8

0.513

ATAD3C

0.495

SPTA1

0.444

AP2B1

0.439

TEPP

0.420

DNAH3

0.420

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AP2B1	C2orf57	ENSP00000482835	ENSP00000315557	AP-2 complex subunit beta; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Testis-expressed protein 44; Chromosome 2 open reading frame 57	0.439
ATAD3C	C2orf57	ENSP00000368062	ENSP00000315557	ATPase family, AAA domain containing 3C; Belongs to the AAA ATPase family	Testis-expressed protein 44; Chromosome 2 open reading frame 57	0.495
ATAD3C	DNAH3	ENSP00000368062	ENSP00000261383	ATPase family, AAA domain containing 3C; Belongs to the AAA ATPase family	Dynein heavy chain 3, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity); Belongs to the dynein heavy chain family	0.489
ATAD3C	TEPP	ENSP00000368062	ENSP00000290871	ATPase family, AAA domain containing 3C; Belongs to the AAA ATPase family	Testis, prostate and placenta expressed	0.491
C19orf70	C2orf57	ENSP00000309561	ENSP00000315557	MICOS complex subunit MIC13; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Constituent of mature MICOS complex, it is required for the formation of cristae junction (CJ) and maintenance of cristae morphology. Required for the incorporation of MINOS1/MIC10 into the MICOS complex	Testis-expressed protein 44; Chromosome 2 open reading frame 57	0.747
C2orf57	AP2B1	ENSP00000315557	ENSP00000482835	Testis-expressed protein 44; Chromosome 2 open reading frame 57	AP-2 complex subunit beta; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.439
C2orf57	ATAD3C	ENSP00000315557	ENSP00000368062	Testis-expressed protein 44; Chromosome 2 open reading frame 57	ATPase family, AAA domain containing 3C; Belongs to the AAA ATPase family	0.495
C2orf57	C19orf70	ENSP00000315557	ENSP00000309561	Testis-expressed protein 44; Chromosome 2 open reading frame 57	MICOS complex subunit MIC13; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Constituent of mature MICOS complex, it is required for the formation of cristae junction (CJ) and maintenance of cristae morphology. Required for the incorporation of MINOS1/MIC10 into the MICOS complex	0.747
C2orf57	DNAH3	ENSP00000315557	ENSP00000261383	Testis-expressed protein 44; Chromosome 2 open reading frame 57	Dynein heavy chain 3, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity); Belongs to the dynein heavy chain family	0.420
C2orf57	DNAH8	ENSP00000315557	ENSP00000333363	Testis-expressed protein 44; Chromosome 2 open reading frame 57	Dynein heavy chain 8, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity); Dyneins, axonemal	0.513
C2orf57	MPC2	ENSP00000315557	ENSP00000356820	Testis-expressed protein 44; Chromosome 2 open reading frame 57	Mitochondrial pyruvate carrier 2; Mediates the uptake of pyruvate into mitochondria; Solute carriers	0.794
C2orf57	SPTA1	ENSP00000315557	ENSP00000357129	Testis-expressed protein 44; Chromosome 2 open reading frame 57	Spectrin alpha chain, erythrocytic 1; Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane; EF-hand domain containing	0.444
C2orf57	TEPP	ENSP00000315557	ENSP00000290871	Testis-expressed protein 44; Chromosome 2 open reading frame 57	Testis, prostate and placenta expressed	0.420
C2orf57	TEX37	ENSP00000315557	ENSP00000307142	Testis-expressed protein 44; Chromosome 2 open reading frame 57	Testis-expressed sequence 37 protein; Testis expressed 37	0.839
C2orf57	TIMM17B	ENSP00000315557	ENSP00000379999	Testis-expressed protein 44; Chromosome 2 open reading frame 57	Translocase of inner mitochondrial membrane 17B; TIM23 complex	0.766
DNAH3	ATAD3C	ENSP00000261383	ENSP00000368062	Dynein heavy chain 3, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity); Belongs to the dynein heavy chain family	ATPase family, AAA domain containing 3C; Belongs to the AAA ATPase family	0.489
DNAH3	C2orf57	ENSP00000261383	ENSP00000315557	Dynein heavy chain 3, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity); Belongs to the dynein heavy chain family	Testis-expressed protein 44; Chromosome 2 open reading frame 57	0.420
DNAH3	DNAH8	ENSP00000261383	ENSP00000333363	Dynein heavy chain 3, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity); Belongs to the dynein heavy chain family	Dynein heavy chain 8, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity); Dyneins, axonemal	0.918
DNAH3	TEPP	ENSP00000261383	ENSP00000290871	Dynein heavy chain 3, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity); Belongs to the dynein heavy chain family	Testis, prostate and placenta expressed	0.418
DNAH8	C2orf57	ENSP00000333363	ENSP00000315557	Dynein heavy chain 8, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity); Dyneins, axonemal	Testis-expressed protein 44; Chromosome 2 open reading frame 57	0.513

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