• Version:
  • 11.0 [archived version]
STRINGSTRING
HEATR5B HEATR5B PLEKHH3 PLEKHH3 CDK11A CDK11A MYCL MYCL NRAS NRAS HKR1 HKR1 GPR135 GPR135 TRIM28 TRIM28 RNF103 RNF103 GPATCH1 GPATCH1 FAM110A FAM110A
"HKR1" - Krueppel-related zinc finger protein 1 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurence
Coexpression
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[Homology]
Score
HKR1Krueppel-related zinc finger protein 1; May be involved in transcriptional regulation; Zinc fingers C2H2-type (659 aa)    
Predicted Functional Partners:
TRIM28
Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] (835 aa)
     
  0.904
NRAS
GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (189 aa)
       
 
  0.523
RNF103
E3 ubiquitin-protein ligase RNF103; Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway; Ring finger proteins (685 aa)
     
 
  0.519
GPR135
Probable G-protein coupled receptor 135; Orphan receptor; G protein-coupled receptors, Class A orphans (494 aa)
       
 
  0.517
PLEKHH3
Pleckstrin homology, MyTH4 and FERM domain containing H3 (793 aa)
     
 
  0.488
FAM110A
Protein FAM110A; Family with sequence similarity 110 member A; Belongs to the FAM110 family (295 aa)
           
  0.478
MYCL
Protein L-Myc; MYCL proto-oncogene, bHLH transcription factor; Basic helix-loop-helix proteins (394 aa)
           
  0.470
HEATR5B
HEAT repeat-containing protein 5B; Armadillo-like helical domain containing (2071 aa)
     
   
  0.455
CDK11A
Cyclin dependent kinase 11A (780 aa)
     
      0.451
GPATCH1
G-patch domain containing 1; Belongs to the GPATCH1 family (931 aa)
           
  0.441
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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