| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DFNA5 | OSBPL3 | ENSP00000339587 | ENSP00000315410 | Gasdermin-E; Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 | Oxysterol-binding protein-related protein 3; Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes. Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With VAPA, may regulate ER morphology. Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion. Binds to phosphoinositides with preference for PI(3,4)P2 [...] | 0.581 |
| DFNB59 | HNRNPA3 | ENSP00000386647 | ENSP00000376309 | Pejvakin; Essential in the activity of auditory pathway neurons | Heterogeneous nuclear ribonucleoprotein A3; Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing; RNA binding motif containing | 0.672 |
| DFNB59 | NFE2L2 | ENSP00000386647 | ENSP00000380252 | Pejvakin; Essential in the activity of auditory pathway neurons | Nuclear factor erythroid 2-related factor 2; Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region; Basic leucine zipper proteins | 0.420 |
| DFNB59 | NFE2L3 | ENSP00000386647 | ENSP00000056233 | Pejvakin; Essential in the activity of auditory pathway neurons | Nuclear factor erythroid 2-related factor 3; Activates erythroid-specific, globin gene expression; Basic leucine zipper proteins | 0.601 |
| DFNB59 | OSBPL3 | ENSP00000386647 | ENSP00000315410 | Pejvakin; Essential in the activity of auditory pathway neurons | Oxysterol-binding protein-related protein 3; Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes. Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With VAPA, may regulate ER morphology. Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion. Binds to phosphoinositides with preference for PI(3,4)P2 [...] | 0.692 |
| GOLGA4 | NT5C3A | ENSP00000349305 | ENSP00000484415 | Golgin subfamily A member 4; May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1 | Cytosolic 5’-nucleotidase 3A; Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate; Belongs to the pyrimidine 5’-nucleotidase family | 0.638 |
| GOLGA4 | OSBPL3 | ENSP00000349305 | ENSP00000315410 | Golgin subfamily A member 4; May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1 | Oxysterol-binding protein-related protein 3; Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes. Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With VAPA, may regulate ER morphology. Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion. Binds to phosphoinositides with preference for PI(3,4)P2 [...] | 0.573 |
| HNRNPA3 | DFNB59 | ENSP00000376309 | ENSP00000386647 | Heterogeneous nuclear ribonucleoprotein A3; Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing; RNA binding motif containing | Pejvakin; Essential in the activity of auditory pathway neurons | 0.672 |
| HNRNPA3 | NFE2L2 | ENSP00000376309 | ENSP00000380252 | Heterogeneous nuclear ribonucleoprotein A3; Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing; RNA binding motif containing | Nuclear factor erythroid 2-related factor 2; Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region; Basic leucine zipper proteins | 0.645 |
| HNRNPA3 | NFE2L3 | ENSP00000376309 | ENSP00000056233 | Heterogeneous nuclear ribonucleoprotein A3; Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing; RNA binding motif containing | Nuclear factor erythroid 2-related factor 3; Activates erythroid-specific, globin gene expression; Basic leucine zipper proteins | 0.647 |
| HNRNPA3 | OSBPL3 | ENSP00000376309 | ENSP00000315410 | Heterogeneous nuclear ribonucleoprotein A3; Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing; RNA binding motif containing | Oxysterol-binding protein-related protein 3; Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes. Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With VAPA, may regulate ER morphology. Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion. Binds to phosphoinositides with preference for PI(3,4)P2 [...] | 0.666 |
| NFE2L2 | DFNB59 | ENSP00000380252 | ENSP00000386647 | Nuclear factor erythroid 2-related factor 2; Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region; Basic leucine zipper proteins | Pejvakin; Essential in the activity of auditory pathway neurons | 0.420 |
| NFE2L2 | HNRNPA3 | ENSP00000380252 | ENSP00000376309 | Nuclear factor erythroid 2-related factor 2; Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region; Basic leucine zipper proteins | Heterogeneous nuclear ribonucleoprotein A3; Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing; RNA binding motif containing | 0.645 |
| NFE2L2 | NFE2L3 | ENSP00000380252 | ENSP00000056233 | Nuclear factor erythroid 2-related factor 2; Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region; Basic leucine zipper proteins | Nuclear factor erythroid 2-related factor 3; Activates erythroid-specific, globin gene expression; Basic leucine zipper proteins | 0.658 |
| NFE2L2 | OSBPL3 | ENSP00000380252 | ENSP00000315410 | Nuclear factor erythroid 2-related factor 2; Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region; Basic leucine zipper proteins | Oxysterol-binding protein-related protein 3; Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes. Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With VAPA, may regulate ER morphology. Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion. Binds to phosphoinositides with preference for PI(3,4)P2 [...] | 0.628 |
| NFE2L3 | DFNB59 | ENSP00000056233 | ENSP00000386647 | Nuclear factor erythroid 2-related factor 3; Activates erythroid-specific, globin gene expression; Basic leucine zipper proteins | Pejvakin; Essential in the activity of auditory pathway neurons | 0.601 |
| NFE2L3 | HNRNPA3 | ENSP00000056233 | ENSP00000376309 | Nuclear factor erythroid 2-related factor 3; Activates erythroid-specific, globin gene expression; Basic leucine zipper proteins | Heterogeneous nuclear ribonucleoprotein A3; Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing; RNA binding motif containing | 0.647 |
| NFE2L3 | NFE2L2 | ENSP00000056233 | ENSP00000380252 | Nuclear factor erythroid 2-related factor 3; Activates erythroid-specific, globin gene expression; Basic leucine zipper proteins | Nuclear factor erythroid 2-related factor 2; Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region; Basic leucine zipper proteins | 0.658 |
| NFE2L3 | OSBPL3 | ENSP00000056233 | ENSP00000315410 | Nuclear factor erythroid 2-related factor 3; Activates erythroid-specific, globin gene expression; Basic leucine zipper proteins | Oxysterol-binding protein-related protein 3; Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes. Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With VAPA, may regulate ER morphology. Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion. Binds to phosphoinositides with preference for PI(3,4)P2 [...] | 0.673 |
| NT5C3A | GOLGA4 | ENSP00000484415 | ENSP00000349305 | Cytosolic 5’-nucleotidase 3A; Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate; Belongs to the pyrimidine 5’-nucleotidase family | Golgin subfamily A member 4; May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1 | 0.638 |
