ASPRV1 protein (human) - STRING database

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ASPRV1

Retroviral-like aspartic protease 1; Gag like LTR retrotransposon derived genes (343 aa)

Predicted Functional Partners:

TMEM37

0.771

PI15

0.621

GPR162

0.602

TWF2

0.583

GLIPR1

0.573

CELF3

0.567

ASNA1

0.544

GLIPR2

0.527

ELMOD3

0.519

PRDM10

0.511

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASNA1	ASPRV1	ENSP00000466379	ENSP00000315383	ATPase ASNA1; ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	Retroviral-like aspartic protease 1; Gag like LTR retrotransposon derived genes	0.544
ASPRV1	ASNA1	ENSP00000315383	ENSP00000466379	Retroviral-like aspartic protease 1; Gag like LTR retrotransposon derived genes	ATPase ASNA1; ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	0.544
ASPRV1	CELF3	ENSP00000315383	ENSP00000290583	Retroviral-like aspartic protease 1; Gag like LTR retrotransposon derived genes	CUGBP Elav-like family member 3; RNA-binding protein involved in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA	0.567
ASPRV1	ELMOD3	ENSP00000315383	ENSP00000318264	Retroviral-like aspartic protease 1; Gag like LTR retrotransposon derived genes	ELMO domain-containing protein 3; Acts as a GTPase-activating protein (GAP) for ARL2 with low specific activity; Deafness associated genes	0.519
ASPRV1	GLIPR1	ENSP00000315383	ENSP00000266659	Retroviral-like aspartic protease 1; Gag like LTR retrotransposon derived genes	Glioma pathogenesis-related protein 1; GLI pathogenesis related family 1	0.573
ASPRV1	GLIPR2	ENSP00000315383	ENSP00000367196	Retroviral-like aspartic protease 1; Gag like LTR retrotransposon derived genes	Golgi-associated plant pathogenesis-related protein 1; GLI pathogenesis related 2; CAP superfamily	0.527
ASPRV1	GPR162	ENSP00000315383	ENSP00000311528	Retroviral-like aspartic protease 1; Gag like LTR retrotransposon derived genes	Probable G-protein coupled receptor 162; Orphan receptor; G protein-coupled receptors, Class A orphans	0.602
ASPRV1	PI15	ENSP00000315383	ENSP00000260113	Retroviral-like aspartic protease 1; Gag like LTR retrotransposon derived genes	Peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin. May play a role in facial patterning during embryonic development (By similarity); Belongs to the CRISP family	0.621
ASPRV1	PRDM10	ENSP00000315383	ENSP00000351686	Retroviral-like aspartic protease 1; Gag like LTR retrotransposon derived genes	PR domain zinc finger protein 10; May be involved in transcriptional regulation; PR/SET domain family	0.511
ASPRV1	TMEM37	ENSP00000315383	ENSP00000303148	Retroviral-like aspartic protease 1; Gag like LTR retrotransposon derived genes	Voltage-dependent calcium channel gamma-like subunit; Thought to stabilize the calcium channel in an inactivated (closed) state. Modulates calcium current when coexpressed with CACNA1G (By similarity)	0.771
ASPRV1	TWF2	ENSP00000315383	ENSP00000303908	Retroviral-like aspartic protease 1; Gag like LTR retrotransposon derived genes	Twinfilin-2; Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity); Belongs to the actin-binding proteins ADF family. Twinfilin subfamily	0.583
CELF3	ASPRV1	ENSP00000290583	ENSP00000315383	CUGBP Elav-like family member 3; RNA-binding protein involved in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA	Retroviral-like aspartic protease 1; Gag like LTR retrotransposon derived genes	0.567
CELF3	TWF2	ENSP00000290583	ENSP00000303908	CUGBP Elav-like family member 3; RNA-binding protein involved in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA	Twinfilin-2; Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity); Belongs to the actin-binding proteins ADF family. Twinfilin subfamily	0.559
ELMOD3	ASPRV1	ENSP00000318264	ENSP00000315383	ELMO domain-containing protein 3; Acts as a GTPase-activating protein (GAP) for ARL2 with low specific activity; Deafness associated genes	Retroviral-like aspartic protease 1; Gag like LTR retrotransposon derived genes	0.519
GLIPR1	ASPRV1	ENSP00000266659	ENSP00000315383	Glioma pathogenesis-related protein 1; GLI pathogenesis related family 1	Retroviral-like aspartic protease 1; Gag like LTR retrotransposon derived genes	0.573
GLIPR1	GLIPR2	ENSP00000266659	ENSP00000367196	Glioma pathogenesis-related protein 1; GLI pathogenesis related family 1	Golgi-associated plant pathogenesis-related protein 1; GLI pathogenesis related 2; CAP superfamily	0.795
GLIPR1	TMEM37	ENSP00000266659	ENSP00000303148	Glioma pathogenesis-related protein 1; GLI pathogenesis related family 1	Voltage-dependent calcium channel gamma-like subunit; Thought to stabilize the calcium channel in an inactivated (closed) state. Modulates calcium current when coexpressed with CACNA1G (By similarity)	0.418
GLIPR2	ASPRV1	ENSP00000367196	ENSP00000315383	Golgi-associated plant pathogenesis-related protein 1; GLI pathogenesis related 2; CAP superfamily	Retroviral-like aspartic protease 1; Gag like LTR retrotransposon derived genes	0.527
GLIPR2	GLIPR1	ENSP00000367196	ENSP00000266659	Golgi-associated plant pathogenesis-related protein 1; GLI pathogenesis related 2; CAP superfamily	Glioma pathogenesis-related protein 1; GLI pathogenesis related family 1	0.795
GLIPR2	PI15	ENSP00000367196	ENSP00000260113	Golgi-associated plant pathogenesis-related protein 1; GLI pathogenesis related 2; CAP superfamily	Peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin. May play a role in facial patterning during embryonic development (By similarity); Belongs to the CRISP family	0.401

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