node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANO5 | CAPN3 | ENSP00000315371 | ENSP00000380349 | Anoctamin-5; Does not exhibit calcium-activated chloride channel (CaCC) activity; Anoctamins | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Calpains | 0.593 |
ANO5 | DYSF | ENSP00000315371 | ENSP00000386881 | Anoctamin-5; Does not exhibit calcium-activated chloride channel (CaCC) activity; Anoctamins | Dysferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity); Ferlin family | 0.794 |
ANO5 | FKRP | ENSP00000315371 | ENSP00000326570 | Anoctamin-5; Does not exhibit calcium-activated chloride channel (CaCC) activity; Anoctamins | Fukutin-related protein; Transferase involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine- beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity | 0.716 |
ANO5 | MMD2 | ENSP00000315371 | ENSP00000384690 | Anoctamin-5; Does not exhibit calcium-activated chloride channel (CaCC) activity; Anoctamins | Monocyte to macrophage differentiation associated 2; Progestin and adipoQ receptor family | 0.805 |
ANO5 | MYOT | ENSP00000315371 | ENSP00000239926 | Anoctamin-5; Does not exhibit calcium-activated chloride channel (CaCC) activity; Anoctamins | Myotilin; Component of a complex of multiple actin cross-linking proteins. Involved in the control of myofibril assembly and stability at the Z lines in muscle cells; I-set domain containing | 0.649 |
ANO5 | NELL1 | ENSP00000315371 | ENSP00000298925 | Anoctamin-5; Does not exhibit calcium-activated chloride channel (CaCC) activity; Anoctamins | Protein kinase C-binding protein NELL1; Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization | 0.808 |
ANO5 | NELL2 | ENSP00000315371 | ENSP00000416341 | Anoctamin-5; Does not exhibit calcium-activated chloride channel (CaCC) activity; Anoctamins | Protein kinase C-binding protein NELL2; Required for neuron survival through the modulation of MAPK pathways (By similarity). Involved in the regulation of hypothalamic GNRH secretion and the control of puberty (By similarity) | 0.807 |
ANO5 | SGCA | ENSP00000315371 | ENSP00000262018 | Anoctamin-5; Does not exhibit calcium-activated chloride channel (CaCC) activity; Anoctamins | Alpha-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix | 0.597 |
ANO5 | SGCB | ENSP00000315371 | ENSP00000370839 | Anoctamin-5; Does not exhibit calcium-activated chloride channel (CaCC) activity; Anoctamins | Beta-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix | 0.622 |
ANO5 | SGCG | ENSP00000315371 | ENSP00000218867 | Anoctamin-5; Does not exhibit calcium-activated chloride channel (CaCC) activity; Anoctamins | Gamma-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix | 0.601 |
CAPN3 | ANO5 | ENSP00000380349 | ENSP00000315371 | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Calpains | Anoctamin-5; Does not exhibit calcium-activated chloride channel (CaCC) activity; Anoctamins | 0.593 |
CAPN3 | DYSF | ENSP00000380349 | ENSP00000386881 | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Calpains | Dysferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity); Ferlin family | 0.909 |
CAPN3 | FKRP | ENSP00000380349 | ENSP00000326570 | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Calpains | Fukutin-related protein; Transferase involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine- beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity | 0.669 |
CAPN3 | MYOT | ENSP00000380349 | ENSP00000239926 | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Calpains | Myotilin; Component of a complex of multiple actin cross-linking proteins. Involved in the control of myofibril assembly and stability at the Z lines in muscle cells; I-set domain containing | 0.682 |
CAPN3 | SGCA | ENSP00000380349 | ENSP00000262018 | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Calpains | Alpha-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix | 0.612 |
CAPN3 | SGCB | ENSP00000380349 | ENSP00000370839 | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Calpains | Beta-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix | 0.562 |
CAPN3 | SGCG | ENSP00000380349 | ENSP00000218867 | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Calpains | Gamma-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix | 0.597 |
DYSF | ANO5 | ENSP00000386881 | ENSP00000315371 | Dysferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity); Ferlin family | Anoctamin-5; Does not exhibit calcium-activated chloride channel (CaCC) activity; Anoctamins | 0.794 |
DYSF | CAPN3 | ENSP00000386881 | ENSP00000380349 | Dysferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity); Ferlin family | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Calpains | 0.909 |
DYSF | FKRP | ENSP00000386881 | ENSP00000326570 | Dysferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity); Ferlin family | Fukutin-related protein; Transferase involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine- beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity | 0.756 |