• Version:
  • 11.0 [archived version]
STRINGSTRING
ENSG00000108825 ENSG00000108825 LYNX1 LYNX1 AARSD1 AARSD1 GPR115 GPR115 SERPINB7 SERPINB7 C5orf46 C5orf46 MAGEB6 MAGEB6 WFDC5 WFDC5 ACTL8 ACTL8 PPCS PPCS SLC32A1 SLC32A1
"C5orf46" - Uncharacterized protein C5orf46 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
C5orf46Uncharacterized protein C5orf46; Chromosome 5 open reading frame 46 (87 aa)    
Predicted Functional Partners:
PPCS
Phosphopantothenate--cysteine ligase; Catalyzes the first step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4’- phosphopantothenate to form 4-phosphopantothenoylcysteine; Belongs to the PPC synthetase family (311 aa)
       
      0.692
GPR115
Adhesion G protein-coupled receptor F4; Orphan receptor (695 aa)
           
  0.654
SLC32A1
Vesicular inhibitory amino acid transporter; Involved in the uptake of GABA and glycine into the synaptic vesicles; Solute carriers (525 aa)
           
  0.629
WFDC5
WAP four-disulfide core domain protein 5; Putative acid-stable proteinase inhibitor; WAP four-disulfide core domain containing (123 aa)
     
   
  0.549
MAGEB6
Melanoma-associated antigen B6; MAGE family member B6 (407 aa)
           
  0.510
ENSG00000108825
PTGES3L-AARSD1 readthrough; Functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala) (586 aa)
           
  0.497
SERPINB7
Serpin B7; Might function as an inhibitor of Lys-specific proteases. Might influence the maturation of megakaryocytes via its action as a serpin; Serpin peptidase inhibitors (380 aa)
     
   
  0.492
AARSD1
Alanyl-tRNA editing protein Aarsd1; Functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala) (412 aa)
           
  0.474
LYNX1
Ly-6/neurotoxin-like protein 1; Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). The proposed role as modulator of nAChR activity seems to be dependent on the nAChR subtype and stoichiometry, and to involve an effect on nAChR trafficking and its cell surface expression, and on single channel properties of the nAChR inserted in the plasma membrane. Modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and e [...] (131 aa)
           
  0.473
ACTL8
Actin-like protein 8; Actin related proteins (366 aa)
           
  0.472
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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