ARL6IP6 protein (human) - STRING database

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ARL6IP6

ADP ribosylation factor like GTPase 6 interacting protein 6; Belongs to the ARL6IP6 family (226 aa)

Predicted Functional Partners:

ATP6V1A

0.704

FMNL2

0.561

ATAD2B

0.547

TMED8

0.533

DUSP3

0.527

IL13RA1

0.525

CCDC69

0.511

ARL14EP

0.511

PLEKHH2

0.440

SDF2

0.438

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARL14EP	ARL6IP6	ENSP00000282032	ENSP00000315357	ARL14 effector protein; Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells	ADP ribosylation factor like GTPase 6 interacting protein 6; Belongs to the ARL6IP6 family	0.511
ARL14EP	CCDC69	ENSP00000282032	ENSP00000347586	ARL14 effector protein; Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells	Coiled-coil domain-containing protein 69; May act as a scaffold to regulate the recruitment and assembly of spindle midzone components. Required for the localization of AURKB and PLK1 to the spindle midzone	0.519
ARL6IP6	ARL14EP	ENSP00000315357	ENSP00000282032	ADP ribosylation factor like GTPase 6 interacting protein 6; Belongs to the ARL6IP6 family	ARL14 effector protein; Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells	0.511
ARL6IP6	ATAD2B	ENSP00000315357	ENSP00000238789	ADP ribosylation factor like GTPase 6 interacting protein 6; Belongs to the ARL6IP6 family	ATPase family, AAA domain containing 2B	0.547
ARL6IP6	ATP6V1A	ENSP00000315357	ENSP00000273398	ADP ribosylation factor like GTPase 6 interacting protein 6; Belongs to the ARL6IP6 family	V-type proton ATPase catalytic subunit A; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation; Belongs to the ATPase alpha/beta chains family	0.704
ARL6IP6	CCDC69	ENSP00000315357	ENSP00000347586	ADP ribosylation factor like GTPase 6 interacting protein 6; Belongs to the ARL6IP6 family	Coiled-coil domain-containing protein 69; May act as a scaffold to regulate the recruitment and assembly of spindle midzone components. Required for the localization of AURKB and PLK1 to the spindle midzone	0.511
ARL6IP6	DUSP3	ENSP00000315357	ENSP00000226004	ADP ribosylation factor like GTPase 6 interacting protein 6; Belongs to the ARL6IP6 family	Dual specificity protein phosphatase 3; Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2; Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily	0.527
ARL6IP6	FMNL2	ENSP00000315357	ENSP00000288670	ADP ribosylation factor like GTPase 6 interacting protein 6; Belongs to the ARL6IP6 family	Formin-like protein 2; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics; Belongs to the formin homology family	0.561
ARL6IP6	IL13RA1	ENSP00000315357	ENSP00000360730	ADP ribosylation factor like GTPase 6 interacting protein 6; Belongs to the ARL6IP6 family	Interleukin-13 receptor subunit alpha-1; Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity; Belongs to the type I cytokine receptor family. Type 5 subfamily	0.525
ARL6IP6	PLEKHH2	ENSP00000315357	ENSP00000282406	ADP ribosylation factor like GTPase 6 interacting protein 6; Belongs to the ARL6IP6 family	Pleckstrin homology domain-containing family H member 2; In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia; FERM domain containing	0.440
ARL6IP6	SDF2	ENSP00000315357	ENSP00000247020	ADP ribosylation factor like GTPase 6 interacting protein 6; Belongs to the ARL6IP6 family	Stromal cell derived factor 2	0.438
ARL6IP6	TMED8	ENSP00000315357	ENSP00000216468	ADP ribosylation factor like GTPase 6 interacting protein 6; Belongs to the ARL6IP6 family	Protein TMED8; Transmembrane p24 trafficking protein family member 8; GOLD domain containing	0.533
ATAD2B	ARL6IP6	ENSP00000238789	ENSP00000315357	ATPase family, AAA domain containing 2B	ADP ribosylation factor like GTPase 6 interacting protein 6; Belongs to the ARL6IP6 family	0.547
ATAD2B	SDF2	ENSP00000238789	ENSP00000247020	ATPase family, AAA domain containing 2B	Stromal cell derived factor 2	0.456
ATP6V1A	ARL6IP6	ENSP00000273398	ENSP00000315357	V-type proton ATPase catalytic subunit A; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation; Belongs to the ATPase alpha/beta chains family	ADP ribosylation factor like GTPase 6 interacting protein 6; Belongs to the ARL6IP6 family	0.704
CCDC69	ARL14EP	ENSP00000347586	ENSP00000282032	Coiled-coil domain-containing protein 69; May act as a scaffold to regulate the recruitment and assembly of spindle midzone components. Required for the localization of AURKB and PLK1 to the spindle midzone	ARL14 effector protein; Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells	0.519
CCDC69	ARL6IP6	ENSP00000347586	ENSP00000315357	Coiled-coil domain-containing protein 69; May act as a scaffold to regulate the recruitment and assembly of spindle midzone components. Required for the localization of AURKB and PLK1 to the spindle midzone	ADP ribosylation factor like GTPase 6 interacting protein 6; Belongs to the ARL6IP6 family	0.511
DUSP3	ARL6IP6	ENSP00000226004	ENSP00000315357	Dual specificity protein phosphatase 3; Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2; Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily	ADP ribosylation factor like GTPase 6 interacting protein 6; Belongs to the ARL6IP6 family	0.527
FMNL2	ARL6IP6	ENSP00000288670	ENSP00000315357	Formin-like protein 2; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics; Belongs to the formin homology family	ADP ribosylation factor like GTPase 6 interacting protein 6; Belongs to the ARL6IP6 family	0.561
IL13RA1	ARL6IP6	ENSP00000360730	ENSP00000315357	Interleukin-13 receptor subunit alpha-1; Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity; Belongs to the type I cytokine receptor family. Type 5 subfamily	ADP ribosylation factor like GTPase 6 interacting protein 6; Belongs to the ARL6IP6 family	0.525

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