EDDM3A protein (human) - STRING database

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EDDM3A

Epididymal secretory protein E3-alpha; Possible function in sperm maturation (147 aa)

Predicted Functional Partners:

PTGER3

0.669

PTGER4

0.580

PTGER1

0.543

POTEB2

0.526

ENSG00000276760

0.510

ENSG00000233917

0.510

WFDC2

0.501

SPAG11B

0.450

DEFB128

0.414

LY6G5C

0.406

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DEFB128	EDDM3A	ENSP00000335382	ENSP00000315098	Beta-defensin 128; Has antibacterial activity; Defensins, beta	Epididymal secretory protein E3-alpha; Possible function in sperm maturation	0.414
EDDM3A	DEFB128	ENSP00000315098	ENSP00000335382	Epididymal secretory protein E3-alpha; Possible function in sperm maturation	Beta-defensin 128; Has antibacterial activity; Defensins, beta	0.414
EDDM3A	ENSG00000233917	ENSP00000315098	ENSP00000457689	Epididymal secretory protein E3-alpha; Possible function in sperm maturation	POTE ankyrin domain family member B; Belongs to the POTE family	0.510
EDDM3A	ENSG00000276760	ENSP00000315098	ENSP00000478796	Epididymal secretory protein E3-alpha; Possible function in sperm maturation	POTE ankyrin domain family member B	0.510
EDDM3A	LY6G5C	ENSP00000315098	ENSP00000372724	Epididymal secretory protein E3-alpha; Possible function in sperm maturation	Lymphocyte antigen 6 complex locus protein G5c; May have a role in hematopoietic cell differentiation; LY6/PLAUR domain containing	0.406
EDDM3A	POTEB2	ENSP00000315098	ENSP00000456953	Epididymal secretory protein E3-alpha; Possible function in sperm maturation	POTE ankyrin domain family member B2; Belongs to the POTE family	0.526
EDDM3A	PTGER1	ENSP00000315098	ENSP00000292513	Epididymal secretory protein E3-alpha; Possible function in sperm maturation	Prostaglandin E2 receptor EP1 subtype; Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues; Belongs to the G-protein coupled receptor 1 family	0.543
EDDM3A	PTGER3	ENSP00000315098	ENSP00000349003	Epididymal secretory protein E3-alpha; Possible function in sperm maturation	Prostaglandin E2 receptor EP3 subtype; Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messe [...]	0.669
EDDM3A	PTGER4	ENSP00000315098	ENSP00000302846	Epididymal secretory protein E3-alpha; Possible function in sperm maturation	Prostaglandin E2 receptor EP4 subtype; Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function	0.580
EDDM3A	SPAG11B	ENSP00000315098	ENSP00000381480	Epididymal secretory protein E3-alpha; Possible function in sperm maturation	Sperm-associated antigen 11A; Sperm associated antigen 11B; Belongs to the SPAG11 family	0.450
EDDM3A	WFDC2	ENSP00000315098	ENSP00000361761	Epididymal secretory protein E3-alpha; Possible function in sperm maturation	WAP four-disulfide core domain protein 2; Broad range protease inhibitor; WAP four-disulfide core domain containing	0.501
ENSG00000233917	EDDM3A	ENSP00000457689	ENSP00000315098	POTE ankyrin domain family member B; Belongs to the POTE family	Epididymal secretory protein E3-alpha; Possible function in sperm maturation	0.510
ENSG00000276760	EDDM3A	ENSP00000478796	ENSP00000315098	POTE ankyrin domain family member B	Epididymal secretory protein E3-alpha; Possible function in sperm maturation	0.510
LY6G5C	EDDM3A	ENSP00000372724	ENSP00000315098	Lymphocyte antigen 6 complex locus protein G5c; May have a role in hematopoietic cell differentiation; LY6/PLAUR domain containing	Epididymal secretory protein E3-alpha; Possible function in sperm maturation	0.406
LY6G5C	WFDC2	ENSP00000372724	ENSP00000361761	Lymphocyte antigen 6 complex locus protein G5c; May have a role in hematopoietic cell differentiation; LY6/PLAUR domain containing	WAP four-disulfide core domain protein 2; Broad range protease inhibitor; WAP four-disulfide core domain containing	0.544
POTEB2	EDDM3A	ENSP00000456953	ENSP00000315098	POTE ankyrin domain family member B2; Belongs to the POTE family	Epididymal secretory protein E3-alpha; Possible function in sperm maturation	0.526
PTGER1	EDDM3A	ENSP00000292513	ENSP00000315098	Prostaglandin E2 receptor EP1 subtype; Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues; Belongs to the G-protein coupled receptor 1 family	Epididymal secretory protein E3-alpha; Possible function in sperm maturation	0.543
PTGER1	PTGER3	ENSP00000292513	ENSP00000349003	Prostaglandin E2 receptor EP1 subtype; Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues; Belongs to the G-protein coupled receptor 1 family	Prostaglandin E2 receptor EP3 subtype; Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messe [...]	0.516
PTGER3	EDDM3A	ENSP00000349003	ENSP00000315098	Prostaglandin E2 receptor EP3 subtype; Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messe [...]	Epididymal secretory protein E3-alpha; Possible function in sperm maturation	0.669
PTGER3	PTGER1	ENSP00000349003	ENSP00000292513	Prostaglandin E2 receptor EP3 subtype; Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messe [...]	Prostaglandin E2 receptor EP1 subtype; Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues; Belongs to the G-protein coupled receptor 1 family	0.516

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