node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARRDC3 | LYSMD3 | ENSP00000265138 | ENSP00000314518 | Arrestin domain-containing protein 3; Adapter protein that plays a role in regulating cell- surface expression of adrenergic receptors and probably also other G protein-coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes; Belongs to the arrestin family | LysM and putative peptidoglycan-binding domain-containing protein 3; LysM domain containing 3 | 0.731 |
ARRDC3 | MBLAC2 | ENSP00000265138 | ENSP00000314776 | Arrestin domain-containing protein 3; Adapter protein that plays a role in regulating cell- surface expression of adrenergic receptors and probably also other G protein-coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes; Belongs to the arrestin family | Metallo-beta-lactamase domain containing 2; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family | 0.438 |
CETN3 | LYSMD3 | ENSP00000428259 | ENSP00000314518 | Centrin-3; EF-hand domain containing | LysM and putative peptidoglycan-binding domain-containing protein 3; LysM domain containing 3 | 0.462 |
CETN3 | MBLAC2 | ENSP00000428259 | ENSP00000314776 | Centrin-3; EF-hand domain containing | Metallo-beta-lactamase domain containing 2; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family | 0.489 |
ETHE1 | MBLAC1 | ENSP00000292147 | ENSP00000381150 | Persulfide dioxygenase ETHE1, mitochondrial; Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic [...] | Metallo-beta-lactamase domain containing 1 | 0.429 |
ETHE1 | MBLAC2 | ENSP00000292147 | ENSP00000314776 | Persulfide dioxygenase ETHE1, mitochondrial; Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic [...] | Metallo-beta-lactamase domain containing 2; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family | 0.450 |
GPR98 | LYSMD3 | ENSP00000384582 | ENSP00000314518 | G-protein coupled receptor 98; Receptor that may have an important role in the development of the central nervous system; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | LysM and putative peptidoglycan-binding domain-containing protein 3; LysM domain containing 3 | 0.644 |
GPR98 | MBLAC2 | ENSP00000384582 | ENSP00000314776 | G-protein coupled receptor 98; Receptor that may have an important role in the development of the central nervous system; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | Metallo-beta-lactamase domain containing 2; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family | 0.470 |
HAGHL | MBLAC1 | ENSP00000374353 | ENSP00000381150 | Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds | Metallo-beta-lactamase domain containing 1 | 0.653 |
HAGHL | MBLAC2 | ENSP00000374353 | ENSP00000314776 | Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds | Metallo-beta-lactamase domain containing 2; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family | 0.650 |
LYSMD3 | ARRDC3 | ENSP00000314518 | ENSP00000265138 | LysM and putative peptidoglycan-binding domain-containing protein 3; LysM domain containing 3 | Arrestin domain-containing protein 3; Adapter protein that plays a role in regulating cell- surface expression of adrenergic receptors and probably also other G protein-coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes; Belongs to the arrestin family | 0.731 |
LYSMD3 | CETN3 | ENSP00000314518 | ENSP00000428259 | LysM and putative peptidoglycan-binding domain-containing protein 3; LysM domain containing 3 | Centrin-3; EF-hand domain containing | 0.462 |
LYSMD3 | GPR98 | ENSP00000314518 | ENSP00000384582 | LysM and putative peptidoglycan-binding domain-containing protein 3; LysM domain containing 3 | G-protein coupled receptor 98; Receptor that may have an important role in the development of the central nervous system; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | 0.644 |
LYSMD3 | MBLAC2 | ENSP00000314518 | ENSP00000314776 | LysM and putative peptidoglycan-binding domain-containing protein 3; LysM domain containing 3 | Metallo-beta-lactamase domain containing 2; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family | 0.700 |
LYSMD3 | POLR3G | ENSP00000314518 | ENSP00000382058 | LysM and putative peptidoglycan-binding domain-containing protein 3; LysM domain containing 3 | DNA-directed RNA polymerase III subunit RPC7; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating cata [...] | 0.557 |
MBLAC1 | ETHE1 | ENSP00000381150 | ENSP00000292147 | Metallo-beta-lactamase domain containing 1 | Persulfide dioxygenase ETHE1, mitochondrial; Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic [...] | 0.429 |
MBLAC1 | HAGHL | ENSP00000381150 | ENSP00000374353 | Metallo-beta-lactamase domain containing 1 | Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds | 0.653 |
MBLAC1 | MBLAC2 | ENSP00000381150 | ENSP00000314776 | Metallo-beta-lactamase domain containing 1 | Metallo-beta-lactamase domain containing 2; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family | 0.670 |
MBLAC2 | ARRDC3 | ENSP00000314776 | ENSP00000265138 | Metallo-beta-lactamase domain containing 2; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family | Arrestin domain-containing protein 3; Adapter protein that plays a role in regulating cell- surface expression of adrenergic receptors and probably also other G protein-coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes; Belongs to the arrestin family | 0.438 |
MBLAC2 | CETN3 | ENSP00000314776 | ENSP00000428259 | Metallo-beta-lactamase domain containing 2; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family | Centrin-3; EF-hand domain containing | 0.489 |