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  • 11.0 [archived version]
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ETHE1 ETHE1 MBLAC1 MBLAC1 HAGHL HAGHL OR14C36 OR14C36 MBLAC2 MBLAC2 GPR98 GPR98 VRK1 VRK1 LYSMD3 LYSMD3 POLR3G POLR3G CETN3 CETN3 ARRDC3 ARRDC3
"MBLAC2" - Metallo-beta-lactamase domain containing 2 in Homo sapiens
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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MBLAC2Metallo-beta-lactamase domain containing 2; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family (279 aa)    
Predicted Functional Partners:
LYSMD3
LysM and putative peptidoglycan-binding domain-containing protein 3; LysM domain containing 3 (306 aa)
           
  0.700
MBLAC1
Metallo-beta-lactamase domain containing 1 (266 aa)
           
  0.670
HAGHL
Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds (282 aa)
           
  0.650
POLR3G
DNA-directed RNA polymerase III subunit RPC7; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating cata [...] (223 aa)
           
  0.581
VRK1
Serine/threonine-protein kinase VRK1; Serine/threonine kinase involved in Golgi disassembly during the cell cycle- following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates ’Thr- 18’ of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1- disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosph [...] (396 aa)
     
   
  0.510
CETN3
Centrin-3; EF-hand domain containing (191 aa)
     
   
  0.489
GPR98
G-protein coupled receptor 98; Receptor that may have an important role in the development of the central nervous system; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily (6306 aa)
           
  0.470
ETHE1
Persulfide dioxygenase ETHE1, mitochondrial; Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic [...] (254 aa)
     
   
  0.450
OR14C36
Olfactory receptor 14C36; Odorant receptor; Olfactory receptors, family 14 (312 aa)
           
  0.447
ARRDC3
Arrestin domain-containing protein 3; Adapter protein that plays a role in regulating cell- surface expression of adrenergic receptors and probably also other G protein-coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes; Belongs to the arrestin family (414 aa)
           
  0.438
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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