• Version:
  • 11.0 [archived version]
STRINGSTRING
CACFD1 CACFD1 CORO6 CORO6 ZNF296 ZNF296 HENMT1 HENMT1 RAPGEFL1 RAPGEFL1 MAP6D1 MAP6D1 HSPA12B HSPA12B FAM131A FAM131A YEATS2 YEATS2 VWA5B2 VWA5B2 PARL PARL
"MAP6D1" - MAP6 domain-containing protein 1 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurence
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[Homology]
Score
MAP6D1MAP6 domain-containing protein 1; May have microtubule-stabilizing activity; Belongs to the STOP family (199 aa)    
Predicted Functional Partners:
PARL
Presenilins-associated rhomboid-like protein, mitochondrial; Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain; Rhomboid family (379 aa)
 
       
  0.708
VWA5B2
Von Willebrand factor A domain containing 5B2 (1242 aa)
     
   
  0.636
YEATS2
YEATS domain-containing protein 2; Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. YEATS2 specifically recognizes and binds histone H3 crotonylated at ’Lys-27’ (H3K27cr). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (1422 aa)
           
  0.612
CORO6
Coronin-6; WD repeat domain containing; Coronins (472 aa)
     
   
  0.582
HENMT1
Small RNA 2’-O-methyltransferase; Methyltransferase that adds a 2’-O-methyl group at the 3’-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3’-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis; Seven-beta-strand methyltransferase motif containing (393 aa)
           
  0.578
RAPGEFL1
Rap guanine nucleotide exchange factor-like 1; Probable guanine nucleotide exchange factor (GEF) (456 aa)
     
   
  0.545
CACFD1
Calcium channel flower domain containing 1 (233 aa)
           
  0.536
FAM131A
Protein FAM131A; Family with sequence similarity 131 member A; Belongs to the FAM131 family (366 aa)
           
  0.519
HSPA12B
Heat shock protein family A member 12B; Belongs to the heat shock protein 70 family (686 aa)
           
  0.514
ZNF296
Zinc finger protein 296; May be a transcriptional corepressor with KLF4; Zinc fingers C2H2-type (475 aa)
           
  0.511
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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