node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASB6 | GRINA | ENSP00000277458 | ENSP00000314380 | Ankyrin repeat and SOCS box protein 6; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Ankyrin repeat domain containing | Protein lifeguard 1; Potential apoptotic regulator; Transmembrane BAX inhibitor motif containing | 0.618 |
ASB6 | KTN1 | ENSP00000277458 | ENSP00000378725 | Ankyrin repeat and SOCS box protein 6; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Ankyrin repeat domain containing | Kinectin; Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin; Belongs to the kinectin family | 0.610 |
ASB6 | PDE6A | ENSP00000277458 | ENSP00000255266 | Ankyrin repeat and SOCS box protein 6; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Ankyrin repeat domain containing | Rod cGMP-specific 3’,5’-cyclic phosphodiesterase subunit alpha; This protein participates in processes of transmission and amplification of the visual signal; Belongs to the cyclic nucleotide phosphodiesterase family | 0.632 |
ASB6 | SYF2 | ENSP00000277458 | ENSP00000236273 | Ankyrin repeat and SOCS box protein 6; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Ankyrin repeat domain containing | Pre-mRNA-splicing factor SYF2; May be involved in pre-mRNA splicing; Belongs to the SYF2 family | 0.599 |
GBA | GRINA | ENSP00000314508 | ENSP00000314380 | Glucosylceramidase beta | Protein lifeguard 1; Potential apoptotic regulator; Transmembrane BAX inhibitor motif containing | 0.590 |
GBA | SORD | ENSP00000314508 | ENSP00000267814 | Glucosylceramidase beta | Sorbitol dehydrogenase; Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm; Belongs to the zinc-containing alcohol dehydrogenase family | 0.539 |
GBA | SUOX | ENSP00000314508 | ENSP00000377668 | Glucosylceramidase beta | Sulfite oxidase, mitochondrial; Sulfite oxidase | 0.626 |
GHITM | GRINA | ENSP00000361207 | ENSP00000314380 | Growth hormone-inducible transmembrane protein; Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c; Transmembrane BAX inhibitor motif containing | Protein lifeguard 1; Potential apoptotic regulator; Transmembrane BAX inhibitor motif containing | 0.658 |
GRINA | ASB6 | ENSP00000314380 | ENSP00000277458 | Protein lifeguard 1; Potential apoptotic regulator; Transmembrane BAX inhibitor motif containing | Ankyrin repeat and SOCS box protein 6; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Ankyrin repeat domain containing | 0.618 |
GRINA | GBA | ENSP00000314380 | ENSP00000314508 | Protein lifeguard 1; Potential apoptotic regulator; Transmembrane BAX inhibitor motif containing | Glucosylceramidase beta | 0.590 |
GRINA | GHITM | ENSP00000314380 | ENSP00000361207 | Protein lifeguard 1; Potential apoptotic regulator; Transmembrane BAX inhibitor motif containing | Growth hormone-inducible transmembrane protein; Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c; Transmembrane BAX inhibitor motif containing | 0.658 |
GRINA | KTN1 | ENSP00000314380 | ENSP00000378725 | Protein lifeguard 1; Potential apoptotic regulator; Transmembrane BAX inhibitor motif containing | Kinectin; Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin; Belongs to the kinectin family | 0.590 |
GRINA | PDE6A | ENSP00000314380 | ENSP00000255266 | Protein lifeguard 1; Potential apoptotic regulator; Transmembrane BAX inhibitor motif containing | Rod cGMP-specific 3’,5’-cyclic phosphodiesterase subunit alpha; This protein participates in processes of transmission and amplification of the visual signal; Belongs to the cyclic nucleotide phosphodiesterase family | 0.592 |
GRINA | SORD | ENSP00000314380 | ENSP00000267814 | Protein lifeguard 1; Potential apoptotic regulator; Transmembrane BAX inhibitor motif containing | Sorbitol dehydrogenase; Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm; Belongs to the zinc-containing alcohol dehydrogenase family | 0.593 |
GRINA | SUOX | ENSP00000314380 | ENSP00000377668 | Protein lifeguard 1; Potential apoptotic regulator; Transmembrane BAX inhibitor motif containing | Sulfite oxidase, mitochondrial; Sulfite oxidase | 0.620 |
GRINA | SYF2 | ENSP00000314380 | ENSP00000236273 | Protein lifeguard 1; Potential apoptotic regulator; Transmembrane BAX inhibitor motif containing | Pre-mRNA-splicing factor SYF2; May be involved in pre-mRNA splicing; Belongs to the SYF2 family | 0.604 |
GRINA | TG | ENSP00000314380 | ENSP00000220616 | Protein lifeguard 1; Potential apoptotic regulator; Transmembrane BAX inhibitor motif containing | Thyroglobulin; Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3); Belongs to the type-B carboxylesterase/lipase family | 0.650 |
GRINA | TMBIM6 | ENSP00000314380 | ENSP00000389277 | Protein lifeguard 1; Potential apoptotic regulator; Transmembrane BAX inhibitor motif containing | Bax inhibitor 1; Suppressor of apoptosis. Modulates unfolded protein response signaling. Modulates ER calcium homeostasis by acting as a calcium-leak channel. Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (By similarity); Transmembrane BAX inhibitor motif containing | 0.728 |
KTN1 | ASB6 | ENSP00000378725 | ENSP00000277458 | Kinectin; Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin; Belongs to the kinectin family | Ankyrin repeat and SOCS box protein 6; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Ankyrin repeat domain containing | 0.610 |
KTN1 | GRINA | ENSP00000378725 | ENSP00000314380 | Kinectin; Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin; Belongs to the kinectin family | Protein lifeguard 1; Potential apoptotic regulator; Transmembrane BAX inhibitor motif containing | 0.590 |