• Version:
  • 11.0 [archived version]
STRINGSTRING
OBP2B OBP2B APOD APOD OBP2A OBP2A LCN1 LCN1 LCN8 LCN8 ATG4A ATG4A LCN15 LCN15 IRG1 IRG1 IGSF23 IGSF23 C1orf146 C1orf146 REG4 REG4
"LCN15" - Lipocalin-15 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
LCN15Lipocalin-15; Lipocalin 15; Lipocalins (184 aa)    
Predicted Functional Partners:
LCN1
Lipocalin-1; Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket; Belongs to the calycin superfamily. Lipocalin family (176 aa)
           
  0.661
OBP2A
Odorant-binding protein 2a; Probably binds and transports small hydrophobic volatile molecules with a higher affinity for aldehydes and large fatty acids; Lipocalins (170 aa)
           
  0.657
OBP2B
Odorant-binding protein 2b; Probably binds and transports small hydrophobic volatile molecules; Belongs to the calycin superfamily. Lipocalin family (170 aa)
           
  0.656
LCN8
Epididymal-specific lipocalin-8; May play a role in male fertility. May act as a retinoid carrier protein within the epididymis; Lipocalins (152 aa)
     
   
  0.643
APOD
Apolipoprotein D; APOD occurs in the macromolecular complex with lecithin- cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts; Apolipoproteins (189 aa)
           
  0.613
IGSF23
Immunoglobulin superfamily member 23; Immunoglobulin like domain containing (192 aa)
           
  0.561
ATG4A
Cysteine protease ATG4A; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms (398 aa)
       
      0.534
C1orf146
Uncharacterized protein C1orf146; Chromosome 1 open reading frame 146 (180 aa)
           
  0.534
IRG1
Cis-aconitate decarboxylase; Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)- mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1- mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation (481 aa)
           
  0.506
REG4
Regenerating islet-derived protein 4; Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium; C-type lectin domain containing (158 aa)
           
  0.463
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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