node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APOD | LCN1 | ENSP00000345179 | ENSP00000263598 | Apolipoprotein D; APOD occurs in the macromolecular complex with lecithin- cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts; Apolipoproteins | Lipocalin-1; Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket; Belongs to the calycin superfamily. Lipocalin family | 0.718 |
APOD | LCN15 | ENSP00000345179 | ENSP00000313833 | Apolipoprotein D; APOD occurs in the macromolecular complex with lecithin- cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts; Apolipoproteins | Lipocalin-15; Lipocalin 15; Lipocalins | 0.613 |
APOD | OBP2A | ENSP00000345179 | ENSP00000441028 | Apolipoprotein D; APOD occurs in the macromolecular complex with lecithin- cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts; Apolipoproteins | Odorant-binding protein 2a; Probably binds and transports small hydrophobic volatile molecules with a higher affinity for aldehydes and large fatty acids; Lipocalins | 0.719 |
APOD | OBP2B | ENSP00000345179 | ENSP00000484615 | Apolipoprotein D; APOD occurs in the macromolecular complex with lecithin- cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts; Apolipoproteins | Odorant-binding protein 2b; Probably binds and transports small hydrophobic volatile molecules; Belongs to the calycin superfamily. Lipocalin family | 0.719 |
ATG4A | LCN15 | ENSP00000361306 | ENSP00000313833 | Cysteine protease ATG4A; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms | Lipocalin-15; Lipocalin 15; Lipocalins | 0.534 |
C1orf146 | LCN15 | ENSP00000359401 | ENSP00000313833 | Uncharacterized protein C1orf146; Chromosome 1 open reading frame 146 | Lipocalin-15; Lipocalin 15; Lipocalins | 0.534 |
IGSF23 | LCN15 | ENSP00000385592 | ENSP00000313833 | Immunoglobulin superfamily member 23; Immunoglobulin like domain containing | Lipocalin-15; Lipocalin 15; Lipocalins | 0.561 |
IGSF23 | REG4 | ENSP00000385592 | ENSP00000346158 | Immunoglobulin superfamily member 23; Immunoglobulin like domain containing | Regenerating islet-derived protein 4; Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium; C-type lectin domain containing | 0.716 |
IRG1 | LCN15 | ENSP00000366682 | ENSP00000313833 | Cis-aconitate decarboxylase; Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)- mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1- mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation | Lipocalin-15; Lipocalin 15; Lipocalins | 0.506 |
LCN1 | APOD | ENSP00000263598 | ENSP00000345179 | Lipocalin-1; Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket; Belongs to the calycin superfamily. Lipocalin family | Apolipoprotein D; APOD occurs in the macromolecular complex with lecithin- cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts; Apolipoproteins | 0.718 |
LCN1 | LCN15 | ENSP00000263598 | ENSP00000313833 | Lipocalin-1; Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket; Belongs to the calycin superfamily. Lipocalin family | Lipocalin-15; Lipocalin 15; Lipocalins | 0.661 |
LCN1 | LCN8 | ENSP00000263598 | ENSP00000360753 | Lipocalin-1; Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket; Belongs to the calycin superfamily. Lipocalin family | Epididymal-specific lipocalin-8; May play a role in male fertility. May act as a retinoid carrier protein within the epididymis; Lipocalins | 0.431 |
LCN15 | APOD | ENSP00000313833 | ENSP00000345179 | Lipocalin-15; Lipocalin 15; Lipocalins | Apolipoprotein D; APOD occurs in the macromolecular complex with lecithin- cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts; Apolipoproteins | 0.613 |
LCN15 | ATG4A | ENSP00000313833 | ENSP00000361306 | Lipocalin-15; Lipocalin 15; Lipocalins | Cysteine protease ATG4A; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms | 0.534 |
LCN15 | C1orf146 | ENSP00000313833 | ENSP00000359401 | Lipocalin-15; Lipocalin 15; Lipocalins | Uncharacterized protein C1orf146; Chromosome 1 open reading frame 146 | 0.534 |
LCN15 | IGSF23 | ENSP00000313833 | ENSP00000385592 | Lipocalin-15; Lipocalin 15; Lipocalins | Immunoglobulin superfamily member 23; Immunoglobulin like domain containing | 0.561 |
LCN15 | IRG1 | ENSP00000313833 | ENSP00000366682 | Lipocalin-15; Lipocalin 15; Lipocalins | Cis-aconitate decarboxylase; Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)- mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1- mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation | 0.506 |
LCN15 | LCN1 | ENSP00000313833 | ENSP00000263598 | Lipocalin-15; Lipocalin 15; Lipocalins | Lipocalin-1; Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket; Belongs to the calycin superfamily. Lipocalin family | 0.661 |
LCN15 | LCN8 | ENSP00000313833 | ENSP00000360753 | Lipocalin-15; Lipocalin 15; Lipocalins | Epididymal-specific lipocalin-8; May play a role in male fertility. May act as a retinoid carrier protein within the epididymis; Lipocalins | 0.643 |
LCN15 | OBP2A | ENSP00000313833 | ENSP00000441028 | Lipocalin-15; Lipocalin 15; Lipocalins | Odorant-binding protein 2a; Probably binds and transports small hydrophobic volatile molecules with a higher affinity for aldehydes and large fatty acids; Lipocalins | 0.657 |