| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C1orf111 | HEPHL1 | ENSP00000356912 | ENSP00000313699 | Spermatogenesis-associated protein 46; Play a role in spermiogenesis and fertilization | Hephaestin-like protein 1; May function as a ferroxidase and may be involved in copper transport and homeostasis | 0.630 |
| DENND3 | FHAD1 | ENSP00000262585 | ENSP00000351770 | DENN domain-containing protein 3; Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the deg [...] | Forkhead-associated domain-containing protein 1; Forkhead associated phosphopeptide binding domain 1 | 0.552 |
| DENND3 | HEPHL1 | ENSP00000262585 | ENSP00000313699 | DENN domain-containing protein 3; Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the deg [...] | Hephaestin-like protein 1; May function as a ferroxidase and may be involved in copper transport and homeostasis | 0.565 |
| DENND3 | LRRC38 | ENSP00000262585 | ENSP00000365253 | DENN domain-containing protein 3; Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the deg [...] | Leucine-rich repeat-containing protein 38; Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel’s voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium | 0.506 |
| DENND3 | OR5J2 | ENSP00000262585 | ENSP00000310788 | DENN domain-containing protein 3; Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the deg [...] | Olfactory receptor 5J2; Odorant receptor; Olfactory receptors, family 5 | 0.563 |
| DENND3 | THSD7B | ENSP00000262585 | ENSP00000272643 | DENN domain-containing protein 3; Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the deg [...] | Thrombospondin type-1 domain-containing protein 7B; Thrombospondin type 1 domain containing 7B | 0.530 |
| FHAD1 | DENND3 | ENSP00000351770 | ENSP00000262585 | Forkhead-associated domain-containing protein 1; Forkhead associated phosphopeptide binding domain 1 | DENN domain-containing protein 3; Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the deg [...] | 0.552 |
| FHAD1 | HEPHL1 | ENSP00000351770 | ENSP00000313699 | Forkhead-associated domain-containing protein 1; Forkhead associated phosphopeptide binding domain 1 | Hephaestin-like protein 1; May function as a ferroxidase and may be involved in copper transport and homeostasis | 0.608 |
| FHAD1 | LRRC38 | ENSP00000351770 | ENSP00000365253 | Forkhead-associated domain-containing protein 1; Forkhead associated phosphopeptide binding domain 1 | Leucine-rich repeat-containing protein 38; Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel’s voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium | 0.557 |
| FHAD1 | OR5J2 | ENSP00000351770 | ENSP00000310788 | Forkhead-associated domain-containing protein 1; Forkhead associated phosphopeptide binding domain 1 | Olfactory receptor 5J2; Odorant receptor; Olfactory receptors, family 5 | 0.614 |
| FHAD1 | THSD7B | ENSP00000351770 | ENSP00000272643 | Forkhead-associated domain-containing protein 1; Forkhead associated phosphopeptide binding domain 1 | Thrombospondin type-1 domain-containing protein 7B; Thrombospondin type 1 domain containing 7B | 0.588 |
| HEPHL1 | C1orf111 | ENSP00000313699 | ENSP00000356912 | Hephaestin-like protein 1; May function as a ferroxidase and may be involved in copper transport and homeostasis | Spermatogenesis-associated protein 46; Play a role in spermiogenesis and fertilization | 0.630 |
| HEPHL1 | DENND3 | ENSP00000313699 | ENSP00000262585 | Hephaestin-like protein 1; May function as a ferroxidase and may be involved in copper transport and homeostasis | DENN domain-containing protein 3; Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the deg [...] | 0.565 |
| HEPHL1 | FHAD1 | ENSP00000313699 | ENSP00000351770 | Hephaestin-like protein 1; May function as a ferroxidase and may be involved in copper transport and homeostasis | Forkhead-associated domain-containing protein 1; Forkhead associated phosphopeptide binding domain 1 | 0.608 |
| HEPHL1 | KRT27 | ENSP00000313699 | ENSP00000301656 | Hephaestin-like protein 1; May function as a ferroxidase and may be involved in copper transport and homeostasis | Keratin, type I cytoskeletal 27; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) | 0.563 |
| HEPHL1 | LRRC38 | ENSP00000313699 | ENSP00000365253 | Hephaestin-like protein 1; May function as a ferroxidase and may be involved in copper transport and homeostasis | Leucine-rich repeat-containing protein 38; Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel’s voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium | 0.558 |
| HEPHL1 | OR56B1 | ENSP00000313699 | ENSP00000322939 | Hephaestin-like protein 1; May function as a ferroxidase and may be involved in copper transport and homeostasis | Olfactory receptor 56B1; Odorant receptor; Olfactory receptors, family 56 | 0.556 |
| HEPHL1 | OR5J2 | ENSP00000313699 | ENSP00000310788 | Hephaestin-like protein 1; May function as a ferroxidase and may be involved in copper transport and homeostasis | Olfactory receptor 5J2; Odorant receptor; Olfactory receptors, family 5 | 0.647 |
| HEPHL1 | STEAP3 | ENSP00000313699 | ENSP00000376822 | Hephaestin-like protein 1; May function as a ferroxidase and may be involved in copper transport and homeostasis | Metalloreductase STEAP3; Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP; STEAP family | 0.557 |
| HEPHL1 | THSD7B | ENSP00000313699 | ENSP00000272643 | Hephaestin-like protein 1; May function as a ferroxidase and may be involved in copper transport and homeostasis | Thrombospondin type-1 domain-containing protein 7B; Thrombospondin type 1 domain containing 7B | 0.581 |
