| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADAMTSL5 | DOK4 | ENSP00000327608 | ENSP00000344277 | ADAMTS-like protein 5; May play a role in modulation of fibrillin microfibrils in the extracellular matrix (ECM); ADAMTS like | Docking protein 4; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells | 0.631 |
| ADAMTSL5 | TMEM184B | ENSP00000327608 | ENSP00000355210 | ADAMTS-like protein 5; May play a role in modulation of fibrillin microfibrils in the extracellular matrix (ECM); ADAMTS like | Transmembrane protein 184B; May activate the MAP kinase signaling pathway | 0.670 |
| ADAMTSL5 | ZNF436 | ENSP00000327608 | ENSP00000313582 | ADAMTS-like protein 5; May play a role in modulation of fibrillin microfibrils in the extracellular matrix (ECM); ADAMTS like | Zinc finger protein 436; May be a transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.642 |
| DOK4 | ADAMTSL5 | ENSP00000344277 | ENSP00000327608 | Docking protein 4; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells | ADAMTS-like protein 5; May play a role in modulation of fibrillin microfibrils in the extracellular matrix (ECM); ADAMTS like | 0.631 |
| DOK4 | TMEM184B | ENSP00000344277 | ENSP00000355210 | Docking protein 4; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells | Transmembrane protein 184B; May activate the MAP kinase signaling pathway | 0.630 |
| DOK4 | ZNF436 | ENSP00000344277 | ENSP00000313582 | Docking protein 4; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells | Zinc finger protein 436; May be a transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.608 |
| OTUD7A | UBC | ENSP00000305926 | ENSP00000441543 | OTU domain-containing protein 7A; Has deubiquitinating activity towards ’Lys-11’-linked polyubiquitin chains; Belongs to the peptidase C64 family | Polyubiquitin-C; Ubiquitin- Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked- Lys-6-linked may be involved in DNA repair; [...] | 0.957 |
| OTUD7A | UBD | ENSP00000305926 | ENSP00000366249 | OTU domain-containing protein 7A; Has deubiquitinating activity towards ’Lys-11’-linked polyubiquitin chains; Belongs to the peptidase C64 family | Ubiquitin D; Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear tr [...] | 0.461 |
| OTUD7A | YOD1 | ENSP00000305926 | ENSP00000326813 | OTU domain-containing protein 7A; Has deubiquitinating activity towards ’Lys-11’-linked polyubiquitin chains; Belongs to the peptidase C64 family | Ubiquitin thioesterase OTU1; Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP’s axial channel. Mediates deubiquitination of ’Lys-27’-, ’Lys-29’- and ’Lys-33’-linked polyubiquitin chains. A [...] | 0.560 |
| OTUD7A | ZNF436 | ENSP00000305926 | ENSP00000313582 | OTU domain-containing protein 7A; Has deubiquitinating activity towards ’Lys-11’-linked polyubiquitin chains; Belongs to the peptidase C64 family | Zinc finger protein 436; May be a transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.719 |
| TMEM184B | ADAMTSL5 | ENSP00000355210 | ENSP00000327608 | Transmembrane protein 184B; May activate the MAP kinase signaling pathway | ADAMTS-like protein 5; May play a role in modulation of fibrillin microfibrils in the extracellular matrix (ECM); ADAMTS like | 0.670 |
| TMEM184B | DOK4 | ENSP00000355210 | ENSP00000344277 | Transmembrane protein 184B; May activate the MAP kinase signaling pathway | Docking protein 4; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells | 0.630 |
| TMEM184B | ZNF436 | ENSP00000355210 | ENSP00000313582 | Transmembrane protein 184B; May activate the MAP kinase signaling pathway | Zinc finger protein 436; May be a transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.652 |
| TRIM28 | ZNF436 | ENSP00000253024 | ENSP00000313582 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 436; May be a transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.956 |
| UBC | OTUD7A | ENSP00000441543 | ENSP00000305926 | Polyubiquitin-C; Ubiquitin- Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked- Lys-6-linked may be involved in DNA repair; [...] | OTU domain-containing protein 7A; Has deubiquitinating activity towards ’Lys-11’-linked polyubiquitin chains; Belongs to the peptidase C64 family | 0.957 |
| UBC | USP5 | ENSP00000441543 | ENSP00000229268 | Polyubiquitin-C; Ubiquitin- Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked- Lys-6-linked may be involved in DNA repair; [...] | Ubiquitin carboxyl-terminal hydrolase 5; Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored ’Lys-48’-linked polyubiquitin disassembly. Binds linear and ’Lys- 63’-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition; Ubiquitin specific peptidases | 0.998 |
| UBC | YOD1 | ENSP00000441543 | ENSP00000326813 | Polyubiquitin-C; Ubiquitin- Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked- Lys-6-linked may be involved in DNA repair; [...] | Ubiquitin thioesterase OTU1; Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP’s axial channel. Mediates deubiquitination of ’Lys-27’-, ’Lys-29’- and ’Lys-33’-linked polyubiquitin chains. A [...] | 0.980 |
| UBC | ZNF436 | ENSP00000441543 | ENSP00000313582 | Polyubiquitin-C; Ubiquitin- Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked- Lys-6-linked may be involved in DNA repair; [...] | Zinc finger protein 436; May be a transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.583 |
| UBD | OTUD7A | ENSP00000366249 | ENSP00000305926 | Ubiquitin D; Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear tr [...] | OTU domain-containing protein 7A; Has deubiquitinating activity towards ’Lys-11’-linked polyubiquitin chains; Belongs to the peptidase C64 family | 0.461 |
| UBD | USP5 | ENSP00000366249 | ENSP00000229268 | Ubiquitin D; Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear tr [...] | Ubiquitin carboxyl-terminal hydrolase 5; Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored ’Lys-48’-linked polyubiquitin disassembly. Binds linear and ’Lys- 63’-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition; Ubiquitin specific peptidases | 0.744 |
