• Version:
  • 11.0 [archived version]
STRINGSTRING
NAGA NAGA SP140L SP140L TPRXL TPRXL NHSL1 NHSL1 PRR18 PRR18 FAM109B FAM109B C10orf53 C10orf53 FAM109A FAM109A PLEKHJ1 PLEKHJ1 INPP5B INPP5B OCRL OCRL
"FAM109B" - Sesquipedalian-2 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
FAM109BSesquipedalian-2; Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane; Belongs to the sesquipedalian family (259 aa)    
Predicted Functional Partners:
OCRL
Inositol polyphosphate 5-phosphatase OCRL-1; Converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Also converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate and inositol 1,3,4,5- tetrakisphosphate to inositol 1,3,4-trisphosphate. May function in lysosomal membrane trafficking by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with lysosomes. Involved in primary cilia assembly; Belongs to the inositol 1,4,5-trisphosphate 5- phosphatase type II family (901 aa)
       
 
  0.933
INPP5B
Type II inositol 1,4,5-trisphosphate 5-phosphatase; Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events; Phosphoinositide phosphatases (913 aa)
       
 
  0.924
PLEKHJ1
Pleckstrin homology domain containing J1 (277 aa)
       
      0.855
FAM109A
Sesquipedalian-1; Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane; Pleckstrin homology domain containing (262 aa)
     
 
0.793
C10orf53
Chromosome 10 open reading frame 53 (157 aa)
           
  0.705
TPRXL
Tetra-peptide repeat homeobox-like; PRD class homeoboxes and pseudogenes (139 aa)
           
  0.558
NHSL1
NHS-like protein 1; NHS like 1; Belongs to the NHS family (1610 aa)
           
  0.556
PRR18
Proline-rich protein 18; Proline rich 18 (295 aa)
           
  0.552
SP140L
SP140 nuclear body protein like; Bromodomain containing (580 aa)
           
  0.539
NAGA
Alpha-N-acetylgalactosaminidase; Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids (411 aa)
     
 
  0.535
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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