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STRINGSTRING
WDR81 WDR81 FBXW12 FBXW12 C17orf105 C17orf105 CCDC24 CCDC24 C5orf52 C5orf52 TMEM136 TMEM136 TMEM42 TMEM42 IGFLR1 IGFLR1 DNAJC5G DNAJC5G CCDC116 CCDC116 TEX37 TEX37
"TMEM136" - Transmembrane protein 136 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
TMEM136Transmembrane protein 136; Belongs to the TMEM136 family (267 aa)    
Predicted Functional Partners:
C17orf105
Uncharacterized protein C17orf105; Chromosome 17 open reading frame 105 (164 aa)
            
  0.643
C5orf52
Uncharacterized protein C5orf52; Chromosome 5 open reading frame 52 (159 aa)
            
  0.642
TMEM42
Transmembrane protein 42 (159 aa)
            
  0.555
CCDC116
Coiled-coil domain containing 116 (613 aa)
            
  0.533
CCDC24
Coiled-coil domain containing 24 (307 aa)
            
  0.529
DNAJC5G
DnaJ heat shock protein family member C5 gamma (189 aa)
            
  0.524
TEX37
Testis-expressed sequence 37 protein; Testis expressed 37 (180 aa)
            
  0.515
IGFLR1
IGF-like family receptor 1; Probable cell membrane receptor for the IGF-like family proteins. Binds IGFL1 and IGFL3 with a higher affinity. May also bind IGFL2 (355 aa)
            
  0.482
FBXW12
F-box/WD repeat-containing protein 12; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and WD repeat domain containing (464 aa)
            
  0.472
WDR81
WD repeat-containing protein 81; Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome. May also play a role in aggrephagy, the macroautophagic [...] (1941 aa)
            
  0.443
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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