• Version:
  • 11.0 [archived version]
STRINGSTRING
TMEM14B TMEM14B SERF2 SERF2 TMEM54 TMEM54 PTPRH PTPRH MFSD3 MFSD3 TMEM134 TMEM134 ROGDI ROGDI VPS13C VPS13C HSD11B1L HSD11B1L TMEM183A TMEM183A ZDHHC12 ZDHHC12
"TMEM134" - Transmembrane protein 134 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TMEM134Transmembrane protein 134 (195 aa)    
Predicted Functional Partners:
TMEM183A
Transmembrane protein 183A (376 aa)
           
  0.522
TMEM14B
Transmembrane protein 14B (151 aa)
           
  0.473
ZDHHC12
Probable palmitoyltransferase ZDHHC12; Zinc finger DHHC-type containing 12; Belongs to the DHHC palmitoyltransferase family (267 aa)
           
  0.473
VPS13C
Vacuolar protein sorting-associated protein 13C; Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential. Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization (3753 aa)
           
  0.464
PTPRH
Receptor-type tyrosine-protein phosphatase H; Protein phosphatase that may contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associated substrates and thus negatively regulating integrin-promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms- inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activati [...] (1115 aa)
           
  0.451
MFSD3
Major facilitator superfamily domain containing 3 (412 aa)
           
  0.444
TMEM54
Transmembrane protein 54 (222 aa)
           
  0.420
ROGDI
Protein rogdi homolog; May act as a positive regulator of cell proliferation; Belongs to the rogdi family (287 aa)
           
  0.418
HSD11B1L
Hydroxysteroid 11-beta-dehydrogenase 1-like protein; Short chain dehydrogenase/reductase superfamily; Belongs to the short-chain dehydrogenases/reductases (SDR) family (333 aa)
           
  0.408
SERF2
Small EDRK-rich factor 2 (170 aa)
           
  0.405
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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