node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATP5S | EVX2 | ENSP00000308334 | ENSP00000312385 | ATP synthase subunit s, mitochondrial; Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway (By similarity) | Homeobox even-skipped homolog protein 2; HOXL subclass homeoboxes; Belongs to the even-skipped homeobox family | 0.513 |
BPIFB3 | EVX2 | ENSP00000364643 | ENSP00000312385 | BPI fold-containing family B member 3; May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity); BPI fold containing | Homeobox even-skipped homolog protein 2; HOXL subclass homeoboxes; Belongs to the even-skipped homeobox family | 0.513 |
EVX2 | ATP5S | ENSP00000312385 | ENSP00000308334 | Homeobox even-skipped homolog protein 2; HOXL subclass homeoboxes; Belongs to the even-skipped homeobox family | ATP synthase subunit s, mitochondrial; Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway (By similarity) | 0.513 |
EVX2 | BPIFB3 | ENSP00000312385 | ENSP00000364643 | Homeobox even-skipped homolog protein 2; HOXL subclass homeoboxes; Belongs to the even-skipped homeobox family | BPI fold-containing family B member 3; May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity); BPI fold containing | 0.513 |
EVX2 | GAL3ST3 | ENSP00000312385 | ENSP00000308591 | Homeobox even-skipped homolog protein 2; HOXL subclass homeoboxes; Belongs to the even-skipped homeobox family | Galactose-3-O-sulfotransferase 3; Transfers a sulfate to position 3 of non-reducing beta- galactosyl residues in N-glycans and core2-branched O-glycans. Has high activity towards Gal-beta-1,4-GlcNAc, Gal-beta-1,4(Fuc-alpha- 1,3)GlcNAc and lower activity towards Gal-beta-1,3(Fuc-alpha- 1,4)GlcNAc; Belongs to the galactose-3-O-sulfotransferase family | 0.472 |
EVX2 | ITIH6 | ENSP00000312385 | ENSP00000218436 | Homeobox even-skipped homolog protein 2; HOXL subclass homeoboxes; Belongs to the even-skipped homeobox family | Inter-alpha-trypsin inhibitor heavy chain family member 6; Belongs to the ITIH family | 0.702 |
EVX2 | KIAA1715 | ENSP00000312385 | ENSP00000272748 | Homeobox even-skipped homolog protein 2; HOXL subclass homeoboxes; Belongs to the even-skipped homeobox family | Endoplasmic reticulum junction formation protein lunapark; Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology. Involved in the stabilization of nascent three-way ER tubular junctions within the ER network. May also play a role as a curvature-stabilizing protein within the three-way ER tubular junction network. May be involved in limb and central nervous system development (By similarity) | 0.751 |
EVX2 | MTX2 | ENSP00000312385 | ENSP00000249442 | Homeobox even-skipped homolog protein 2; HOXL subclass homeoboxes; Belongs to the even-skipped homeobox family | Metaxin-2; Involved in transport of proteins into the mitochondrion | 0.711 |
EVX2 | NR2E1 | ENSP00000312385 | ENSP00000357979 | Homeobox even-skipped homolog protein 2; HOXL subclass homeoboxes; Belongs to the even-skipped homeobox family | Nuclear receptor subfamily 2 group E member 1; Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half- site sequence 5’-AAGGTCA-3’ in which the 5’ flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity). May be involved [...] | 0.472 |
EVX2 | SKOR2 | ENSP00000312385 | ENSP00000483333 | Homeobox even-skipped homolog protein 2; HOXL subclass homeoboxes; Belongs to the even-skipped homeobox family | SKI family transcriptional corepressor 2; Exhibits transcriptional repressor activity (By similarity). Acts as a TGF-beta antagonist in the nervous system; SKI transcriptional corepressors | 0.606 |
EVX2 | SPERT | ENSP00000312385 | ENSP00000309189 | Homeobox even-skipped homolog protein 2; HOXL subclass homeoboxes; Belongs to the even-skipped homeobox family | Spermatid-associated protein; Spermatid associated | 0.474 |
EVX2 | SPOP | ENSP00000312385 | ENSP00000377001 | Homeobox even-skipped homolog protein 2; HOXL subclass homeoboxes; Belongs to the even-skipped homeobox family | Speckle-type POZ protein; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of H2AFY and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING-base [...] | 0.543 |
GAL3ST3 | EVX2 | ENSP00000308591 | ENSP00000312385 | Galactose-3-O-sulfotransferase 3; Transfers a sulfate to position 3 of non-reducing beta- galactosyl residues in N-glycans and core2-branched O-glycans. Has high activity towards Gal-beta-1,4-GlcNAc, Gal-beta-1,4(Fuc-alpha- 1,3)GlcNAc and lower activity towards Gal-beta-1,3(Fuc-alpha- 1,4)GlcNAc; Belongs to the galactose-3-O-sulfotransferase family | Homeobox even-skipped homolog protein 2; HOXL subclass homeoboxes; Belongs to the even-skipped homeobox family | 0.472 |
ITIH6 | EVX2 | ENSP00000218436 | ENSP00000312385 | Inter-alpha-trypsin inhibitor heavy chain family member 6; Belongs to the ITIH family | Homeobox even-skipped homolog protein 2; HOXL subclass homeoboxes; Belongs to the even-skipped homeobox family | 0.702 |
KIAA1715 | EVX2 | ENSP00000272748 | ENSP00000312385 | Endoplasmic reticulum junction formation protein lunapark; Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology. Involved in the stabilization of nascent three-way ER tubular junctions within the ER network. May also play a role as a curvature-stabilizing protein within the three-way ER tubular junction network. May be involved in limb and central nervous system development (By similarity) | Homeobox even-skipped homolog protein 2; HOXL subclass homeoboxes; Belongs to the even-skipped homeobox family | 0.751 |
KIAA1715 | MTX2 | ENSP00000272748 | ENSP00000249442 | Endoplasmic reticulum junction formation protein lunapark; Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology. Involved in the stabilization of nascent three-way ER tubular junctions within the ER network. May also play a role as a curvature-stabilizing protein within the three-way ER tubular junction network. May be involved in limb and central nervous system development (By similarity) | Metaxin-2; Involved in transport of proteins into the mitochondrion | 0.920 |
MTX2 | EVX2 | ENSP00000249442 | ENSP00000312385 | Metaxin-2; Involved in transport of proteins into the mitochondrion | Homeobox even-skipped homolog protein 2; HOXL subclass homeoboxes; Belongs to the even-skipped homeobox family | 0.711 |
MTX2 | KIAA1715 | ENSP00000249442 | ENSP00000272748 | Metaxin-2; Involved in transport of proteins into the mitochondrion | Endoplasmic reticulum junction formation protein lunapark; Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology. Involved in the stabilization of nascent three-way ER tubular junctions within the ER network. May also play a role as a curvature-stabilizing protein within the three-way ER tubular junction network. May be involved in limb and central nervous system development (By similarity) | 0.920 |
NR2E1 | EVX2 | ENSP00000357979 | ENSP00000312385 | Nuclear receptor subfamily 2 group E member 1; Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half- site sequence 5’-AAGGTCA-3’ in which the 5’ flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity). May be involved [...] | Homeobox even-skipped homolog protein 2; HOXL subclass homeoboxes; Belongs to the even-skipped homeobox family | 0.472 |
SKOR2 | EVX2 | ENSP00000483333 | ENSP00000312385 | SKI family transcriptional corepressor 2; Exhibits transcriptional repressor activity (By similarity). Acts as a TGF-beta antagonist in the nervous system; SKI transcriptional corepressors | Homeobox even-skipped homolog protein 2; HOXL subclass homeoboxes; Belongs to the even-skipped homeobox family | 0.606 |