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  • 11.0 [archived version]
STRINGSTRING
SPERT SPERT SPOP SPOP SKOR2 SKOR2 BPIFB3 BPIFB3 NR2E1 NR2E1 EVX2 EVX2 GAL3ST3 GAL3ST3 ATP5S ATP5S KIAA1715 KIAA1715 ITIH6 ITIH6 MTX2 MTX2
"EVX2" - Homeobox even-skipped homolog protein 2 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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EVX2Homeobox even-skipped homolog protein 2; HOXL subclass homeoboxes; Belongs to the even-skipped homeobox family (476 aa)    
Predicted Functional Partners:
KIAA1715
Endoplasmic reticulum junction formation protein lunapark; Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology. Involved in the stabilization of nascent three-way ER tubular junctions within the ER network. May also play a role as a curvature-stabilizing protein within the three-way ER tubular junction network. May be involved in limb and central nervous system development (By similarity) (428 aa)
           
  0.751
MTX2
Metaxin-2; Involved in transport of proteins into the mitochondrion (263 aa)
           
  0.711
ITIH6
Inter-alpha-trypsin inhibitor heavy chain family member 6; Belongs to the ITIH family (1313 aa)
       
      0.702
SKOR2
SKI family transcriptional corepressor 2; Exhibits transcriptional repressor activity (By similarity). Acts as a TGF-beta antagonist in the nervous system; SKI transcriptional corepressors (1015 aa)
     
   
  0.606
SPOP
Speckle-type POZ protein; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of H2AFY and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING-base [...] (374 aa)
           
  0.543
BPIFB3
BPI fold-containing family B member 3; May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity); BPI fold containing (476 aa)
       
      0.513
ATP5S
ATP synthase subunit s, mitochondrial; Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway (By similarity) (215 aa)
       
      0.513
SPERT
Spermatid-associated protein; Spermatid associated (448 aa)
           
  0.474
NR2E1
Nuclear receptor subfamily 2 group E member 1; Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half- site sequence 5’-AAGGTCA-3’ in which the 5’ flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity). May be involved [...] (422 aa)
     
 
  0.472
GAL3ST3
Galactose-3-O-sulfotransferase 3; Transfers a sulfate to position 3 of non-reducing beta- galactosyl residues in N-glycans and core2-branched O-glycans. Has high activity towards Gal-beta-1,4-GlcNAc, Gal-beta-1,4(Fuc-alpha- 1,3)GlcNAc and lower activity towards Gal-beta-1,3(Fuc-alpha- 1,4)GlcNAc; Belongs to the galactose-3-O-sulfotransferase family (431 aa)
           
  0.472
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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