LGI4 protein (human) - STRING database

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Score

LGI4

Leucine rich repeat LGI family member 4 (537 aa)

Predicted Functional Partners:

ADAM22

0.982

ADAM23

0.959

ADAM11

0.959

PLP1

0.560

ADAM28

0.537

FXYD7

0.502

LRRC56

0.470

LRRC46

0.466

CADM4

0.465

AKAP7

0.447

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM11	LGI4	ENSP00000200557	ENSP00000312273	Disintegrin and metalloproteinase domain-containing protein 11; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein; ADAM metallopeptidase domain containing	Leucine rich repeat LGI family member 4	0.959
ADAM22	ADAM23	ENSP00000265727	ENSP00000264377	Disintegrin and metalloproteinase domain-containing protein 22; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1; ADAM metallopeptidase domain containing	Disintegrin and metalloproteinase domain-containing protein 23; May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein; ADAM metallopeptidase domain containing	0.912
ADAM22	LGI4	ENSP00000265727	ENSP00000312273	Disintegrin and metalloproteinase domain-containing protein 22; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1; ADAM metallopeptidase domain containing	Leucine rich repeat LGI family member 4	0.982
ADAM23	ADAM22	ENSP00000264377	ENSP00000265727	Disintegrin and metalloproteinase domain-containing protein 23; May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein; ADAM metallopeptidase domain containing	Disintegrin and metalloproteinase domain-containing protein 22; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1; ADAM metallopeptidase domain containing	0.912
ADAM23	LGI4	ENSP00000264377	ENSP00000312273	Disintegrin and metalloproteinase domain-containing protein 23; May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein; ADAM metallopeptidase domain containing	Leucine rich repeat LGI family member 4	0.959
ADAM28	LGI4	ENSP00000265769	ENSP00000312273	Disintegrin and metalloproteinase domain-containing protein 28; May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation; ADAM metallopeptidase domain containing	Leucine rich repeat LGI family member 4	0.537
AKAP7	LGI4	ENSP00000405252	ENSP00000312273	A-kinase anchor protein 7 isoform gamma; Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane- associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium; A-kinase anchoring proteins	Leucine rich repeat LGI family member 4	0.447
CADM4	LGI4	ENSP00000222374	ENSP00000312273	Cell adhesion molecule 4; Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor- suppressor activity; C2-set domain containing	Leucine rich repeat LGI family member 4	0.465
FXYD7	LGI4	ENSP00000270310	ENSP00000312273	FXYD domain containing ion transport regulator 7; Belongs to the FXYD family	Leucine rich repeat LGI family member 4	0.502
LGI4	ADAM11	ENSP00000312273	ENSP00000200557	Leucine rich repeat LGI family member 4	Disintegrin and metalloproteinase domain-containing protein 11; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein; ADAM metallopeptidase domain containing	0.959
LGI4	ADAM22	ENSP00000312273	ENSP00000265727	Leucine rich repeat LGI family member 4	Disintegrin and metalloproteinase domain-containing protein 22; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1; ADAM metallopeptidase domain containing	0.982
LGI4	ADAM23	ENSP00000312273	ENSP00000264377	Leucine rich repeat LGI family member 4	Disintegrin and metalloproteinase domain-containing protein 23; May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein; ADAM metallopeptidase domain containing	0.959
LGI4	ADAM28	ENSP00000312273	ENSP00000265769	Leucine rich repeat LGI family member 4	Disintegrin and metalloproteinase domain-containing protein 28; May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation; ADAM metallopeptidase domain containing	0.537
LGI4	AKAP7	ENSP00000312273	ENSP00000405252	Leucine rich repeat LGI family member 4	A-kinase anchor protein 7 isoform gamma; Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane- associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium; A-kinase anchoring proteins	0.447
LGI4	CADM4	ENSP00000312273	ENSP00000222374	Leucine rich repeat LGI family member 4	Cell adhesion molecule 4; Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor- suppressor activity; C2-set domain containing	0.465
LGI4	FXYD7	ENSP00000312273	ENSP00000270310	Leucine rich repeat LGI family member 4	FXYD domain containing ion transport regulator 7; Belongs to the FXYD family	0.502
LGI4	LRRC46	ENSP00000312273	ENSP00000269025	Leucine rich repeat LGI family member 4	Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46	0.466
LGI4	LRRC56	ENSP00000312273	ENSP00000270115	Leucine rich repeat LGI family member 4	Leucine-rich repeat-containing protein 56; Leucine rich repeat containing 56	0.470
LGI4	PLP1	ENSP00000312273	ENSP00000481006	Leucine rich repeat LGI family member 4	Myelin proteolipid protein; This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin; Belongs to the myelin proteolipid protein family	0.560
LRRC46	LGI4	ENSP00000269025	ENSP00000312273	Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46	Leucine rich repeat LGI family member 4	0.466

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