DAW1 protein (human) - STRING database

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DAW1

Dynein assembly factor with WDR repeat domains 1; May play a role in axonemal outer row dynein assembly; Belongs to the WD repeat WDR69 family (415 aa)

Predicted Functional Partners:

SPAG6

0.904

PRPF6

0.872

DNAAF3

0.871

PRPF8

0.864

IFT46

0.855

SNRNP200

0.834

LSM8

0.805

DNAAF1

0.787

SPATA9

0.784

EFTUD2

0.778

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DAW1	DNAAF1	ENSP00000311899	ENSP00000367815	Dynein assembly factor with WDR repeat domains 1; May play a role in axonemal outer row dynein assembly; Belongs to the WD repeat WDR69 family	Dynein assembly factor 1, axonemal; Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms. Involved in regulation of microtubule-based cilia and actin-based brush border microvilli	0.787
DAW1	DNAAF3	ENSP00000311899	ENSP00000436975	Dynein assembly factor with WDR repeat domains 1; May play a role in axonemal outer row dynein assembly; Belongs to the WD repeat WDR69 family	Dynein assembly factor 3, axonemal; Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia; Belongs to the DNAAF3 family	0.871
DAW1	EFTUD2	ENSP00000311899	ENSP00000392094	Dynein assembly factor with WDR repeat domains 1; May play a role in axonemal outer row dynein assembly; Belongs to the WD repeat WDR69 family	116 kDa U5 small nuclear ribonucleoprotein component; Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily	0.778
DAW1	IFT46	ENSP00000311899	ENSP00000264020	Dynein assembly factor with WDR repeat domains 1; May play a role in axonemal outer row dynein assembly; Belongs to the WD repeat WDR69 family	Intraflagellar transport proteins; Cilia and flagella associated	0.855
DAW1	LSM8	ENSP00000311899	ENSP00000249299	Dynein assembly factor with WDR repeat domains 1; May play a role in axonemal outer row dynein assembly; Belongs to the WD repeat WDR69 family	U6 snRNA-associated Sm-like protein LSm8; Binds specifically to the 3’-terminal U-tract of U6 snRNA and is probably a component of the spliceosome; Belongs to the snRNP Sm proteins family	0.805
DAW1	PRPF6	ENSP00000311899	ENSP00000266079	Dynein assembly factor with WDR repeat domains 1; May play a role in axonemal outer row dynein assembly; Belongs to the WD repeat WDR69 family	Pre-mRNA-processing factor 6; Involved in pre-mRNA splicing as component of the U4/U6- U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation; U5 small nucleolar ribonucleoprotein	0.872
DAW1	PRPF8	ENSP00000311899	ENSP00000460348	Dynein assembly factor with WDR repeat domains 1; May play a role in axonemal outer row dynein assembly; Belongs to the WD repeat WDR69 family	Pre-mRNA-processing-splicing factor 8; Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5’ and the 3’ splice site	0.864
DAW1	SNRNP200	ENSP00000311899	ENSP00000317123	Dynein assembly factor with WDR repeat domains 1; May play a role in axonemal outer row dynein assembly; Belongs to the WD repeat WDR69 family	U5 small nuclear ribonucleoprotein 200 kDa helicase; RNA helicase that plays an essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome	0.834
DAW1	SPAG6	ENSP00000311899	ENSP00000365811	Dynein assembly factor with WDR repeat domains 1; May play a role in axonemal outer row dynein assembly; Belongs to the WD repeat WDR69 family	Sperm-associated antigen 6; Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility; Armadillo repeat containing	0.904
DAW1	SPATA9	ENSP00000311899	ENSP00000274432	Dynein assembly factor with WDR repeat domains 1; May play a role in axonemal outer row dynein assembly; Belongs to the WD repeat WDR69 family	Spermatogenesis-associated protein 9; May play a role in testicular development/spermatogenesis and may be an important factor in male infertility	0.784
DNAAF1	DAW1	ENSP00000367815	ENSP00000311899	Dynein assembly factor 1, axonemal; Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms. Involved in regulation of microtubule-based cilia and actin-based brush border microvilli	Dynein assembly factor with WDR repeat domains 1; May play a role in axonemal outer row dynein assembly; Belongs to the WD repeat WDR69 family	0.787
DNAAF1	DNAAF3	ENSP00000367815	ENSP00000436975	Dynein assembly factor 1, axonemal; Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms. Involved in regulation of microtubule-based cilia and actin-based brush border microvilli	Dynein assembly factor 3, axonemal; Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia; Belongs to the DNAAF3 family	0.791
DNAAF3	DAW1	ENSP00000436975	ENSP00000311899	Dynein assembly factor 3, axonemal; Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia; Belongs to the DNAAF3 family	Dynein assembly factor with WDR repeat domains 1; May play a role in axonemal outer row dynein assembly; Belongs to the WD repeat WDR69 family	0.871
DNAAF3	DNAAF1	ENSP00000436975	ENSP00000367815	Dynein assembly factor 3, axonemal; Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia; Belongs to the DNAAF3 family	Dynein assembly factor 1, axonemal; Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms. Involved in regulation of microtubule-based cilia and actin-based brush border microvilli	0.791
DNAAF3	SPAG6	ENSP00000436975	ENSP00000365811	Dynein assembly factor 3, axonemal; Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia; Belongs to the DNAAF3 family	Sperm-associated antigen 6; Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility; Armadillo repeat containing	0.529
EFTUD2	DAW1	ENSP00000392094	ENSP00000311899	116 kDa U5 small nuclear ribonucleoprotein component; Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily	Dynein assembly factor with WDR repeat domains 1; May play a role in axonemal outer row dynein assembly; Belongs to the WD repeat WDR69 family	0.778
EFTUD2	LSM8	ENSP00000392094	ENSP00000249299	116 kDa U5 small nuclear ribonucleoprotein component; Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily	U6 snRNA-associated Sm-like protein LSm8; Binds specifically to the 3’-terminal U-tract of U6 snRNA and is probably a component of the spliceosome; Belongs to the snRNP Sm proteins family	0.999
EFTUD2	PRPF6	ENSP00000392094	ENSP00000266079	116 kDa U5 small nuclear ribonucleoprotein component; Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily	Pre-mRNA-processing factor 6; Involved in pre-mRNA splicing as component of the U4/U6- U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation; U5 small nucleolar ribonucleoprotein	0.999
EFTUD2	PRPF8	ENSP00000392094	ENSP00000460348	116 kDa U5 small nuclear ribonucleoprotein component; Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily	Pre-mRNA-processing-splicing factor 8; Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5’ and the 3’ splice site	0.999
EFTUD2	SNRNP200	ENSP00000392094	ENSP00000317123	116 kDa U5 small nuclear ribonucleoprotein component; Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily	U5 small nuclear ribonucleoprotein 200 kDa helicase; RNA helicase that plays an essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome	0.999

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