GRAMD2 protein (human) - STRING database

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GRAMD2

GRAM domain-containing protein 2A; GRAM domain containing 2 (354 aa)

Predicted Functional Partners:

UBL7

0.776

CCDC33

0.742

ADPGK

0.713

EFHC2

0.689

CLK3

0.687

SCAMP5

0.684

TRAF3IP3

0.671

ERICH2

0.643

IGDCC4

0.634

SEMA7A

0.580

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADPGK	CLK3	ENSP00000312250	ENSP00000378505	ADP-dependent glucokinase; Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency (By similarity)	Dual specificity protein kinase CLK3; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells; CDC like kinases	0.545
ADPGK	EFHC2	ENSP00000312250	ENSP00000404232	ADP-dependent glucokinase; Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency (By similarity)	EF-hand domain-containing family member C2; EF-hand domain containing 2	0.590
ADPGK	GRAMD2	ENSP00000312250	ENSP00000311657	ADP-dependent glucokinase; Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency (By similarity)	GRAM domain-containing protein 2A; GRAM domain containing 2	0.713
ADPGK	SCAMP5	ENSP00000312250	ENSP00000355387	ADP-dependent glucokinase; Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency (By similarity)	Secretory carrier-associated membrane protein 5; Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) in case of endoplasmic reticulum stress by inhibiting the endocytosis pathway; Secretory carrier membrane proteins	0.592
CCDC33	GRAMD2	ENSP00000381795	ENSP00000311657	Coiled-coil domain containing 33	GRAM domain-containing protein 2A; GRAM domain containing 2	0.742
CCDC33	SEMA7A	ENSP00000381795	ENSP00000261918	Coiled-coil domain containing 33	Semaphorin-7A; Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes; Belongs to the sem [...]	0.666
CCDC33	UBL7	ENSP00000381795	ENSP00000457703	Coiled-coil domain containing 33	Ubiquitin-like protein 7; Ubiquitin like 7	0.780
CLK3	ADPGK	ENSP00000378505	ENSP00000312250	Dual specificity protein kinase CLK3; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells; CDC like kinases	ADP-dependent glucokinase; Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency (By similarity)	0.545
CLK3	EFHC2	ENSP00000378505	ENSP00000404232	Dual specificity protein kinase CLK3; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells; CDC like kinases	EF-hand domain-containing family member C2; EF-hand domain containing 2	0.574
CLK3	GRAMD2	ENSP00000378505	ENSP00000311657	Dual specificity protein kinase CLK3; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells; CDC like kinases	GRAM domain-containing protein 2A; GRAM domain containing 2	0.687
CLK3	SCAMP5	ENSP00000378505	ENSP00000355387	Dual specificity protein kinase CLK3; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells; CDC like kinases	Secretory carrier-associated membrane protein 5; Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) in case of endoplasmic reticulum stress by inhibiting the endocytosis pathway; Secretory carrier membrane proteins	0.590
CLK3	UBL7	ENSP00000378505	ENSP00000457703	Dual specificity protein kinase CLK3; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells; CDC like kinases	Ubiquitin-like protein 7; Ubiquitin like 7	0.519
EFHC2	ADPGK	ENSP00000404232	ENSP00000312250	EF-hand domain-containing family member C2; EF-hand domain containing 2	ADP-dependent glucokinase; Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency (By similarity)	0.590
EFHC2	CLK3	ENSP00000404232	ENSP00000378505	EF-hand domain-containing family member C2; EF-hand domain containing 2	Dual specificity protein kinase CLK3; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells; CDC like kinases	0.574
EFHC2	GRAMD2	ENSP00000404232	ENSP00000311657	EF-hand domain-containing family member C2; EF-hand domain containing 2	GRAM domain-containing protein 2A; GRAM domain containing 2	0.689
EFHC2	SCAMP5	ENSP00000404232	ENSP00000355387	EF-hand domain-containing family member C2; EF-hand domain containing 2	Secretory carrier-associated membrane protein 5; Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) in case of endoplasmic reticulum stress by inhibiting the endocytosis pathway; Secretory carrier membrane proteins	0.595
ERICH2	GRAMD2	ENSP00000387298	ENSP00000311657	Glutamate-rich protein 2; Glutamate rich 2	GRAM domain-containing protein 2A; GRAM domain containing 2	0.643
GRAMD2	ADPGK	ENSP00000311657	ENSP00000312250	GRAM domain-containing protein 2A; GRAM domain containing 2	ADP-dependent glucokinase; Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency (By similarity)	0.713
GRAMD2	CCDC33	ENSP00000311657	ENSP00000381795	GRAM domain-containing protein 2A; GRAM domain containing 2	Coiled-coil domain containing 33	0.742
GRAMD2	CLK3	ENSP00000311657	ENSP00000378505	GRAM domain-containing protein 2A; GRAM domain containing 2	Dual specificity protein kinase CLK3; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells; CDC like kinases	0.687

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