UGT8 protein (human) - STRING database

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UGT8

2-hydroxyacylsphingosine 1-beta-galactosyltransferase; Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system; Belongs to the UDP-glycosyltransferase family (541 aa)

Predicted Functional Partners:

GAL3ST1

0.953

SGMS1

0.952

DEGS2

0.951

UGCG

0.945

SMPD4

0.940

SGPP2

0.937

SGMS2

0.935

CERS6

0.934

DEGS1

0.932

ASAH1

0.931

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASAH1	CERS6	ENSP00000371152	ENSP00000376453	Acid ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid	Ceramide synthase 6; May be involved in sphingolipid synthesis or its regulation; CERS class homeoboxes	0.694
ASAH1	DEGS1	ENSP00000371152	ENSP00000316476	Acid ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid	Sphingolipid delta(4)-desaturase DES1; Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine); Fatty acid desaturases	0.946
ASAH1	DEGS2	ENSP00000371152	ENSP00000307126	Acid ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid	Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2; Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase; Fatty acid desaturases	0.942
ASAH1	SGMS1	ENSP00000371152	ENSP00000354829	Acid ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid	Phosphatidylcholine-ceramide cholinephosphotransferase 1; Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell [...]	0.952
ASAH1	SGMS2	ENSP00000371152	ENSP00000378176	Acid ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid	Phosphatidylcholine-ceramide cholinephosphotransferase 2; Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Plasma membrane SMS2 can also convert phosphatidylethanolamine (PE) to ceramide phosphatidylethanolamine (CPE). Major form in liver. Required for cell growth in certain cell types. Regulator of cell surface levels of ceramide, an important mediator of signa [...]	0.955
ASAH1	SGPP2	ENSP00000371152	ENSP00000315137	Acid ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid	Sphingosine-1-phosphate phosphatase 2; Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro. May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling	0.939
ASAH1	SMPD4	ENSP00000371152	ENSP00000386531	Acid ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid	Sphingomyelin phosphodiesterase 4; Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide	0.815
ASAH1	UGCG	ENSP00000371152	ENSP00000363397	Acid ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid	Ceramide glucosyltransferase; Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. May also serve as a "flippase"; Belongs to the glycosyltransferase 2 family	0.965
ASAH1	UGT8	ENSP00000371152	ENSP00000311648	Acid ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid	2-hydroxyacylsphingosine 1-beta-galactosyltransferase; Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system; Belongs to the UDP-glycosyltransferase family	0.931
CERS6	ASAH1	ENSP00000376453	ENSP00000371152	Ceramide synthase 6; May be involved in sphingolipid synthesis or its regulation; CERS class homeoboxes	Acid ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid	0.694
CERS6	DEGS1	ENSP00000376453	ENSP00000316476	Ceramide synthase 6; May be involved in sphingolipid synthesis or its regulation; CERS class homeoboxes	Sphingolipid delta(4)-desaturase DES1; Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine); Fatty acid desaturases	0.868
CERS6	DEGS2	ENSP00000376453	ENSP00000307126	Ceramide synthase 6; May be involved in sphingolipid synthesis or its regulation; CERS class homeoboxes	Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2; Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase; Fatty acid desaturases	0.828
CERS6	SGMS1	ENSP00000376453	ENSP00000354829	Ceramide synthase 6; May be involved in sphingolipid synthesis or its regulation; CERS class homeoboxes	Phosphatidylcholine-ceramide cholinephosphotransferase 1; Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell [...]	0.859
CERS6	SGMS2	ENSP00000376453	ENSP00000378176	Ceramide synthase 6; May be involved in sphingolipid synthesis or its regulation; CERS class homeoboxes	Phosphatidylcholine-ceramide cholinephosphotransferase 2; Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Plasma membrane SMS2 can also convert phosphatidylethanolamine (PE) to ceramide phosphatidylethanolamine (CPE). Major form in liver. Required for cell growth in certain cell types. Regulator of cell surface levels of ceramide, an important mediator of signa [...]	0.861
CERS6	SGPP2	ENSP00000376453	ENSP00000315137	Ceramide synthase 6; May be involved in sphingolipid synthesis or its regulation; CERS class homeoboxes	Sphingosine-1-phosphate phosphatase 2; Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro. May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling	0.838
CERS6	SMPD4	ENSP00000376453	ENSP00000386531	Ceramide synthase 6; May be involved in sphingolipid synthesis or its regulation; CERS class homeoboxes	Sphingomyelin phosphodiesterase 4; Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide	0.842
CERS6	UGCG	ENSP00000376453	ENSP00000363397	Ceramide synthase 6; May be involved in sphingolipid synthesis or its regulation; CERS class homeoboxes	Ceramide glucosyltransferase; Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. May also serve as a "flippase"; Belongs to the glycosyltransferase 2 family	0.968
CERS6	UGT8	ENSP00000376453	ENSP00000311648	Ceramide synthase 6; May be involved in sphingolipid synthesis or its regulation; CERS class homeoboxes	2-hydroxyacylsphingosine 1-beta-galactosyltransferase; Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system; Belongs to the UDP-glycosyltransferase family	0.934
DEGS1	ASAH1	ENSP00000316476	ENSP00000371152	Sphingolipid delta(4)-desaturase DES1; Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine); Fatty acid desaturases	Acid ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid	0.946
DEGS1	CERS6	ENSP00000316476	ENSP00000376453	Sphingolipid delta(4)-desaturase DES1; Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine); Fatty acid desaturases	Ceramide synthase 6; May be involved in sphingolipid synthesis or its regulation; CERS class homeoboxes	0.868

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