node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADCY10 | ADCY7 | ENSP00000356825 | ENSP00000378187 | Adenylate cyclase type 10; Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels. Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation; Adenylate cyclases | Adenylate cyclase type 7; This is a membrane-bound, calcium-inhibitable adenylyl cyclase; Adenylate cyclases | 0.663 |
ADCY10 | ADCY8 | ENSP00000356825 | ENSP00000286355 | Adenylate cyclase type 10; Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels. Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation; Adenylate cyclases | Adenylate cyclase type 8; This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity); Adenylate cyclases | 0.726 |
ADCY10 | ADCY9 | ENSP00000356825 | ENSP00000294016 | Adenylate cyclase type 10; Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels. Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation; Adenylate cyclases | Adenylate cyclase type 9; Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein- coupled receptors. Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors; Adenylate cyclases | 0.650 |
ADCY10 | PDE8A | ENSP00000356825 | ENSP00000311453 | Adenylate cyclase type 10; Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels. Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation; Adenylate cyclases | High affinity cAMP-specific and IBMX-insensitive 3’,5’-cyclic phosphodiesterase 8A; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. Binding to RAF1 reduces RAF1 ’Ser- 259’ inhibitory-phosphorylation and stimulates RAF1-dependent EGF- activated ERK-signaling. Protects against cell death induced by hydrogen peroxide and staurosporine; Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily | 0.775 |
ADCY10 | PDE8B | ENSP00000356825 | ENSP00000264917 | Adenylate cyclase type 10; Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels. Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation; Adenylate cyclases | High affinity cAMP-specific and IBMX-insensitive 3’,5’-cyclic phosphodiesterase 8B; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland; Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily | 0.700 |
ADCY7 | ADCY10 | ENSP00000378187 | ENSP00000356825 | Adenylate cyclase type 7; This is a membrane-bound, calcium-inhibitable adenylyl cyclase; Adenylate cyclases | Adenylate cyclase type 10; Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels. Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation; Adenylate cyclases | 0.663 |
ADCY7 | ADCY8 | ENSP00000378187 | ENSP00000286355 | Adenylate cyclase type 7; This is a membrane-bound, calcium-inhibitable adenylyl cyclase; Adenylate cyclases | Adenylate cyclase type 8; This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity); Adenylate cyclases | 0.913 |
ADCY7 | ADCY9 | ENSP00000378187 | ENSP00000294016 | Adenylate cyclase type 7; This is a membrane-bound, calcium-inhibitable adenylyl cyclase; Adenylate cyclases | Adenylate cyclase type 9; Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein- coupled receptors. Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors; Adenylate cyclases | 0.927 |
ADCY7 | PDE8A | ENSP00000378187 | ENSP00000311453 | Adenylate cyclase type 7; This is a membrane-bound, calcium-inhibitable adenylyl cyclase; Adenylate cyclases | High affinity cAMP-specific and IBMX-insensitive 3’,5’-cyclic phosphodiesterase 8A; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. Binding to RAF1 reduces RAF1 ’Ser- 259’ inhibitory-phosphorylation and stimulates RAF1-dependent EGF- activated ERK-signaling. Protects against cell death induced by hydrogen peroxide and staurosporine; Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily | 0.792 |
ADCY7 | PDE8B | ENSP00000378187 | ENSP00000264917 | Adenylate cyclase type 7; This is a membrane-bound, calcium-inhibitable adenylyl cyclase; Adenylate cyclases | High affinity cAMP-specific and IBMX-insensitive 3’,5’-cyclic phosphodiesterase 8B; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland; Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily | 0.699 |
ADCY8 | ADCY10 | ENSP00000286355 | ENSP00000356825 | Adenylate cyclase type 8; This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity); Adenylate cyclases | Adenylate cyclase type 10; Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels. Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation; Adenylate cyclases | 0.726 |
ADCY8 | ADCY7 | ENSP00000286355 | ENSP00000378187 | Adenylate cyclase type 8; This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity); Adenylate cyclases | Adenylate cyclase type 7; This is a membrane-bound, calcium-inhibitable adenylyl cyclase; Adenylate cyclases | 0.913 |
ADCY8 | ADCY9 | ENSP00000286355 | ENSP00000294016 | Adenylate cyclase type 8; This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity); Adenylate cyclases | Adenylate cyclase type 9; Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein- coupled receptors. Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors; Adenylate cyclases | 0.927 |
ADCY8 | PDE8A | ENSP00000286355 | ENSP00000311453 | Adenylate cyclase type 8; This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity); Adenylate cyclases | High affinity cAMP-specific and IBMX-insensitive 3’,5’-cyclic phosphodiesterase 8A; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. Binding to RAF1 reduces RAF1 ’Ser- 259’ inhibitory-phosphorylation and stimulates RAF1-dependent EGF- activated ERK-signaling. Protects against cell death induced by hydrogen peroxide and staurosporine; Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily | 0.787 |
ADCY8 | PDE8B | ENSP00000286355 | ENSP00000264917 | Adenylate cyclase type 8; This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity); Adenylate cyclases | High affinity cAMP-specific and IBMX-insensitive 3’,5’-cyclic phosphodiesterase 8B; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland; Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily | 0.698 |
ADCY9 | ADCY10 | ENSP00000294016 | ENSP00000356825 | Adenylate cyclase type 9; Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein- coupled receptors. Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors; Adenylate cyclases | Adenylate cyclase type 10; Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels. Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation; Adenylate cyclases | 0.650 |
ADCY9 | ADCY7 | ENSP00000294016 | ENSP00000378187 | Adenylate cyclase type 9; Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein- coupled receptors. Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors; Adenylate cyclases | Adenylate cyclase type 7; This is a membrane-bound, calcium-inhibitable adenylyl cyclase; Adenylate cyclases | 0.927 |
ADCY9 | ADCY8 | ENSP00000294016 | ENSP00000286355 | Adenylate cyclase type 9; Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein- coupled receptors. Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors; Adenylate cyclases | Adenylate cyclase type 8; This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity); Adenylate cyclases | 0.927 |
ADCY9 | PDE8A | ENSP00000294016 | ENSP00000311453 | Adenylate cyclase type 9; Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein- coupled receptors. Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors; Adenylate cyclases | High affinity cAMP-specific and IBMX-insensitive 3’,5’-cyclic phosphodiesterase 8A; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. Binding to RAF1 reduces RAF1 ’Ser- 259’ inhibitory-phosphorylation and stimulates RAF1-dependent EGF- activated ERK-signaling. Protects against cell death induced by hydrogen peroxide and staurosporine; Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily | 0.797 |
ADCY9 | PDE8B | ENSP00000294016 | ENSP00000264917 | Adenylate cyclase type 9; Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein- coupled receptors. Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors; Adenylate cyclases | High affinity cAMP-specific and IBMX-insensitive 3’,5’-cyclic phosphodiesterase 8B; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland; Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily | 0.759 |