MUCL1 protein (human) - STRING database

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MUCL1

Mucin-like protein 1; May play a role as marker for the diagnosis of metastatic breast cancer (90 aa)

Predicted Functional Partners:

SCGB2A2

0.954

MUC1

0.932

MUC20

0.921

MUC4

0.917

MUC21

0.917

MUC16

0.915

MUC15

0.912

MUC12

0.911

MUC17

0.910

MUC7

0.908

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MUC1	MUC12	ENSP00000484824	ENSP00000441929	Mucin-1; The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack; CD molecules	Mucin-12; Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF- beta in intestinal epithelium; Mucins	0.969
MUC1	MUC15	ENSP00000484824	ENSP00000416753	Mucin-1; The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack; CD molecules	Mucin-15; May play a role in the cell adhesion to the extracellular matrix; Mucins	0.969
MUC1	MUC16	ENSP00000484824	ENSP00000381008	Mucin-1; The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack; CD molecules	Mucin-16; Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces; Mucins	0.979
MUC1	MUC17	ENSP00000484824	ENSP00000302716	Mucin-1; The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack; CD molecules	Mucin-17; Probably plays a role in maintaining homeostasis on mucosal surfaces; Mucins	0.966
MUC1	MUC20	ENSP00000484824	ENSP00000414350	Mucin-1; The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack; CD molecules	Mucin-20; May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression; Mucins	0.966
MUC1	MUC21	ENSP00000484824	ENSP00000365473	Mucin-1; The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack; CD molecules	Mucin-21; Mucin 21, cell surface associated; Mucins	0.956
MUC1	MUC4	ENSP00000484824	ENSP00000417498	Mucin-1; The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack; CD molecules	Mucin-4; May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 ’Tyr-1248’. In [...]	0.986
MUC1	MUC7	ENSP00000484824	ENSP00000407422	Mucin-1; The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack; CD molecules	Mucin-7; May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili; Mucins	0.972
MUC1	MUCL1	ENSP00000484824	ENSP00000311364	Mucin-1; The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack; CD molecules	Mucin-like protein 1; May play a role as marker for the diagnosis of metastatic breast cancer	0.932
MUC1	SCGB2A2	ENSP00000484824	ENSP00000227918	Mucin-1; The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack; CD molecules	Mammaglobin-A; Secretoglobin family 2A member 2; Secretoglobins	0.551
MUC12	MUC1	ENSP00000441929	ENSP00000484824	Mucin-12; Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF- beta in intestinal epithelium; Mucins	Mucin-1; The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack; CD molecules	0.969
MUC12	MUC15	ENSP00000441929	ENSP00000416753	Mucin-12; Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF- beta in intestinal epithelium; Mucins	Mucin-15; May play a role in the cell adhesion to the extracellular matrix; Mucins	0.978
MUC12	MUC16	ENSP00000441929	ENSP00000381008	Mucin-12; Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF- beta in intestinal epithelium; Mucins	Mucin-16; Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces; Mucins	0.972
MUC12	MUC17	ENSP00000441929	ENSP00000302716	Mucin-12; Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF- beta in intestinal epithelium; Mucins	Mucin-17; Probably plays a role in maintaining homeostasis on mucosal surfaces; Mucins	0.942
MUC12	MUC20	ENSP00000441929	ENSP00000414350	Mucin-12; Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF- beta in intestinal epithelium; Mucins	Mucin-20; May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression; Mucins	0.977
MUC12	MUC21	ENSP00000441929	ENSP00000365473	Mucin-12; Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF- beta in intestinal epithelium; Mucins	Mucin-21; Mucin 21, cell surface associated; Mucins	0.969
MUC12	MUC4	ENSP00000441929	ENSP00000417498	Mucin-12; Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF- beta in intestinal epithelium; Mucins	Mucin-4; May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 ’Tyr-1248’. In [...]	0.938
MUC12	MUC7	ENSP00000441929	ENSP00000407422	Mucin-12; Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF- beta in intestinal epithelium; Mucins	Mucin-7; May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili; Mucins	0.972
MUC12	MUCL1	ENSP00000441929	ENSP00000311364	Mucin-12; Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF- beta in intestinal epithelium; Mucins	Mucin-like protein 1; May play a role as marker for the diagnosis of metastatic breast cancer	0.911
MUC15	MUC1	ENSP00000416753	ENSP00000484824	Mucin-15; May play a role in the cell adhesion to the extracellular matrix; Mucins	Mucin-1; The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack; CD molecules	0.969

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