| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CDX2 | ELF5 | ENSP00000370408 | ENSP00000311010 | Homeobox protein CDX-2; Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine; HOXL subclass homeoboxes | ETS-related transcription factor Elf-5; Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation; Belongs to the ETS family | 0.678 |
| CDX2 | EOMES | ENSP00000370408 | ENSP00000388620 | Homeobox protein CDX-2; Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine; HOXL subclass homeoboxes | Eomesodermin homolog; Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes; T-boxes | 0.777 |
| CDX2 | FOXA1 | ENSP00000370408 | ENSP00000250448 | Homeobox protein CDX-2; Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine; HOXL subclass homeoboxes | Hepatocyte nuclear factor 3-alpha; Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a ’pioneer’ factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5’-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3’ (By similarity). Proposed to play a role in translating the epigenetic signatures [...] | 0.546 |
| CDX2 | GATA3 | ENSP00000370408 | ENSP00000368632 | Homeobox protein CDX-2; Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine; HOXL subclass homeoboxes | Trans-acting T-cell-specific transcription factor GATA-3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5’-AGATAG-3’. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses; GATA zinc finger domain containing | 0.626 |
| CDX2 | KRT18 | ENSP00000370408 | ENSP00000373487 | Homeobox protein CDX-2; Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine; HOXL subclass homeoboxes | Keratin, type I cytoskeletal 18; Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection; Keratins, type I | 0.467 |
| CDX2 | TEAD4 | ENSP00000370408 | ENSP00000352926 | Homeobox protein CDX-2; Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine; HOXL subclass homeoboxes | Transcriptional enhancer factor TEF-3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell [...] | 0.872 |
| ELF5 | CDX2 | ENSP00000311010 | ENSP00000370408 | ETS-related transcription factor Elf-5; Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation; Belongs to the ETS family | Homeobox protein CDX-2; Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine; HOXL subclass homeoboxes | 0.678 |
| ELF5 | EOMES | ENSP00000311010 | ENSP00000388620 | ETS-related transcription factor Elf-5; Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation; Belongs to the ETS family | Eomesodermin homolog; Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes; T-boxes | 0.633 |
| ELF5 | FOXA1 | ENSP00000311010 | ENSP00000250448 | ETS-related transcription factor Elf-5; Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation; Belongs to the ETS family | Hepatocyte nuclear factor 3-alpha; Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a ’pioneer’ factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5’-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3’ (By similarity). Proposed to play a role in translating the epigenetic signatures [...] | 0.540 |
| ELF5 | GATA3 | ENSP00000311010 | ENSP00000368632 | ETS-related transcription factor Elf-5; Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation; Belongs to the ETS family | Trans-acting T-cell-specific transcription factor GATA-3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5’-AGATAG-3’. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses; GATA zinc finger domain containing | 0.626 |
| ELF5 | KRT18 | ENSP00000311010 | ENSP00000373487 | ETS-related transcription factor Elf-5; Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation; Belongs to the ETS family | Keratin, type I cytoskeletal 18; Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection; Keratins, type I | 0.643 |
| ELF5 | PDZD4 | ENSP00000311010 | ENSP00000164640 | ETS-related transcription factor Elf-5; Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation; Belongs to the ETS family | PDZ domain containing 4 | 0.801 |
| ELF5 | STAT5A | ENSP00000311010 | ENSP00000341208 | ETS-related transcription factor Elf-5; Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation; Belongs to the ETS family | Signal transducer and activator of transcription 5A; Carries out a dual function- signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation; SH2 domain containing | 0.696 |
| ELF5 | STAT5B | ENSP00000311010 | ENSP00000293328 | ETS-related transcription factor Elf-5; Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation; Belongs to the ETS family | Signal transducer and activator of transcription 5B; Carries out a dual function- signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation | 0.658 |
| ELF5 | TEAD4 | ENSP00000311010 | ENSP00000352926 | ETS-related transcription factor Elf-5; Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation; Belongs to the ETS family | Transcriptional enhancer factor TEF-3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell [...] | 0.624 |
| ELF5 | WFDC5 | ENSP00000311010 | ENSP00000361875 | ETS-related transcription factor Elf-5; Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation; Belongs to the ETS family | WAP four-disulfide core domain protein 5; Putative acid-stable proteinase inhibitor; WAP four-disulfide core domain containing | 0.802 |
| EOMES | CDX2 | ENSP00000388620 | ENSP00000370408 | Eomesodermin homolog; Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes; T-boxes | Homeobox protein CDX-2; Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine; HOXL subclass homeoboxes | 0.777 |
| EOMES | ELF5 | ENSP00000388620 | ENSP00000311010 | Eomesodermin homolog; Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes; T-boxes | ETS-related transcription factor Elf-5; Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation; Belongs to the ETS family | 0.633 |
| EOMES | GATA3 | ENSP00000388620 | ENSP00000368632 | Eomesodermin homolog; Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes; T-boxes | Trans-acting T-cell-specific transcription factor GATA-3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5’-AGATAG-3’. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses; GATA zinc finger domain containing | 0.811 |
| EOMES | STAT5A | ENSP00000388620 | ENSP00000341208 | Eomesodermin homolog; Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes; T-boxes | Signal transducer and activator of transcription 5A; Carries out a dual function- signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation; SH2 domain containing | 0.491 |
