KRT2 protein (human) - STRING database

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KRT2

Keratin, type II cytoskeletal 2 epidermal; Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization; Keratins, type II (639 aa)

Predicted Functional Partners:

KRT5

0.996

KRT1

0.996

KRT10

0.995

KRT77

0.994

PRSS1

0.932

KRT73

0.930

KRT72

0.926

KRT78

0.923

KRT6C

0.922

KRT33B

0.922

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KRT1	KRT10	ENSP00000252244	ENSP00000269576	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type I cytoskeletal 10; Keratins, type I	0.999
KRT1	KRT2	ENSP00000252244	ENSP00000310861	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type II cytoskeletal 2 epidermal; Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization; Keratins, type II	0.996
KRT1	KRT33B	ENSP00000252244	ENSP00000251646	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type I cuticular Ha3-II; Keratins, type I; Belongs to the intermediate filament family	0.915
KRT1	KRT5	ENSP00000252244	ENSP00000252242	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type II cytoskeletal 5; Keratins, type II	0.997
KRT1	KRT6C	ENSP00000252244	ENSP00000252250	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type II cytoskeletal 6C; Keratins, type II; Belongs to the intermediate filament family	0.913
KRT1	KRT72	ENSP00000252244	ENSP00000293745	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type II cytoskeletal 72; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable)	0.908
KRT1	KRT73	ENSP00000252244	ENSP00000307014	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type II cytoskeletal 73; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable)	0.911
KRT1	KRT77	ENSP00000252244	ENSP00000342710	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type II cytoskeletal 1b; Keratins, type II; Belongs to the intermediate filament family	0.995
KRT1	KRT78	ENSP00000252244	ENSP00000306261	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type II cytoskeletal 78; Keratins, type II	0.905
KRT1	PRSS1	ENSP00000252244	ENSP00000308720	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Trypsin-1; Has activity against the synthetic substrates Boc-Phe- Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val- Pro-Arg-Mec. The single-chain form is more active than the two- chain form against all of these substrates; Belongs to the peptidase S1 family	0.950
KRT10	KRT1	ENSP00000269576	ENSP00000252244	Keratin, type I cytoskeletal 10; Keratins, type I	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	0.999
KRT10	KRT2	ENSP00000269576	ENSP00000310861	Keratin, type I cytoskeletal 10; Keratins, type I	Keratin, type II cytoskeletal 2 epidermal; Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization; Keratins, type II	0.995
KRT10	KRT33B	ENSP00000269576	ENSP00000251646	Keratin, type I cytoskeletal 10; Keratins, type I	Keratin, type I cuticular Ha3-II; Keratins, type I; Belongs to the intermediate filament family	0.902
KRT10	KRT5	ENSP00000269576	ENSP00000252242	Keratin, type I cytoskeletal 10; Keratins, type I	Keratin, type II cytoskeletal 5; Keratins, type II	0.995
KRT10	KRT6C	ENSP00000269576	ENSP00000252250	Keratin, type I cytoskeletal 10; Keratins, type I	Keratin, type II cytoskeletal 6C; Keratins, type II; Belongs to the intermediate filament family	0.925
KRT10	KRT72	ENSP00000269576	ENSP00000293745	Keratin, type I cytoskeletal 10; Keratins, type I	Keratin, type II cytoskeletal 72; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable)	0.931
KRT10	KRT73	ENSP00000269576	ENSP00000307014	Keratin, type I cytoskeletal 10; Keratins, type I	Keratin, type II cytoskeletal 73; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable)	0.923
KRT10	KRT77	ENSP00000269576	ENSP00000342710	Keratin, type I cytoskeletal 10; Keratins, type I	Keratin, type II cytoskeletal 1b; Keratins, type II; Belongs to the intermediate filament family	0.996
KRT10	KRT78	ENSP00000269576	ENSP00000306261	Keratin, type I cytoskeletal 10; Keratins, type I	Keratin, type II cytoskeletal 78; Keratins, type II	0.929
KRT10	PRSS1	ENSP00000269576	ENSP00000308720	Keratin, type I cytoskeletal 10; Keratins, type I	Trypsin-1; Has activity against the synthetic substrates Boc-Phe- Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val- Pro-Arg-Mec. The single-chain form is more active than the two- chain form against all of these substrates; Belongs to the peptidase S1 family	0.957

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