SLC5A6 protein (human) - STRING database

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SLC5A6

Sodium-dependent multivitamin transporter; Transports pantothenate, biotin and lipoate in the presence of sodium; Solute carriers (635 aa)

Predicted Functional Partners:

PDZD11

0.928

HLCS

0.686

SLC16A5

0.652

SLC17A1

0.627

BTD

0.616

T

0.587

SLC37A1

0.574

SLC16A9

0.558

SLC22A12

0.550

SLC39A5

0.544

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BTD	HLCS	ENSP00000400995	ENSP00000382071	Biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation	Biotin--protein ligase; Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl- CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase	0.988
BTD	SLC5A6	ENSP00000400995	ENSP00000310208	Biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation	Sodium-dependent multivitamin transporter; Transports pantothenate, biotin and lipoate in the presence of sodium; Solute carriers	0.616
HLCS	BTD	ENSP00000382071	ENSP00000400995	Biotin--protein ligase; Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl- CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase	Biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation	0.988
HLCS	SLC5A6	ENSP00000382071	ENSP00000310208	Biotin--protein ligase; Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl- CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase	Sodium-dependent multivitamin transporter; Transports pantothenate, biotin and lipoate in the presence of sodium; Solute carriers	0.686
PDZD11	SLC5A6	ENSP00000239666	ENSP00000310208	PDZ domain containing 11	Sodium-dependent multivitamin transporter; Transports pantothenate, biotin and lipoate in the presence of sodium; Solute carriers	0.928
SLC16A5	SLC37A1	ENSP00000390564	ENSP00000344648	Monocarboxylate transporter 6; Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity); Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family	Glucose-6-phosphate exchanger SLC37A1; Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6- phosphatase. May not play a role in homeostatic regulation of blood glucose levels; Belongs to the major facilitator superfamily. Organophosphate-Pi antiporter (OPA) (TC 2.A.1.4) family	0.550
SLC16A5	SLC39A5	ENSP00000390564	ENSP00000266980	Monocarboxylate transporter 6; Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity); Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family	Zinc transporter ZIP5; May play a role in polarized cells by carrying out serosal-to-mucosal zinc transport. Plays a role in eye development. Could regulate the BMP/TGF-beta (bone morphogenetic protein/transforming growth factor-beta) signaling pathway and modulates extracellular matrix (ECM) proteins of the sclera. Seems to play a central role in controlling organismal zinc status (By similarity); Solute carriers	0.549
SLC16A5	SLC5A6	ENSP00000390564	ENSP00000310208	Monocarboxylate transporter 6; Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity); Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family	Sodium-dependent multivitamin transporter; Transports pantothenate, biotin and lipoate in the presence of sodium; Solute carriers	0.652
SLC16A9	SLC17A1	ENSP00000378757	ENSP00000244527	Monocarboxylate transporter 9; Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane; Solute carriers	Sodium-dependent phosphate transport protein 1; Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Plays a role in urate transport in the kidney; Solute carriers	0.751
SLC16A9	SLC22A12	ENSP00000378757	ENSP00000366797	Monocarboxylate transporter 9; Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane; Solute carriers	Solute carrier family 22 member 12; Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family	0.708
SLC16A9	SLC37A1	ENSP00000378757	ENSP00000344648	Monocarboxylate transporter 9; Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane; Solute carriers	Glucose-6-phosphate exchanger SLC37A1; Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6- phosphatase. May not play a role in homeostatic regulation of blood glucose levels; Belongs to the major facilitator superfamily. Organophosphate-Pi antiporter (OPA) (TC 2.A.1.4) family	0.582
SLC16A9	SLC39A5	ENSP00000378757	ENSP00000266980	Monocarboxylate transporter 9; Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane; Solute carriers	Zinc transporter ZIP5; May play a role in polarized cells by carrying out serosal-to-mucosal zinc transport. Plays a role in eye development. Could regulate the BMP/TGF-beta (bone morphogenetic protein/transforming growth factor-beta) signaling pathway and modulates extracellular matrix (ECM) proteins of the sclera. Seems to play a central role in controlling organismal zinc status (By similarity); Solute carriers	0.584
SLC16A9	SLC5A6	ENSP00000378757	ENSP00000310208	Monocarboxylate transporter 9; Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane; Solute carriers	Sodium-dependent multivitamin transporter; Transports pantothenate, biotin and lipoate in the presence of sodium; Solute carriers	0.558
SLC17A1	SLC16A9	ENSP00000244527	ENSP00000378757	Sodium-dependent phosphate transport protein 1; Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Plays a role in urate transport in the kidney; Solute carriers	Monocarboxylate transporter 9; Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane; Solute carriers	0.751
SLC17A1	SLC22A12	ENSP00000244527	ENSP00000366797	Sodium-dependent phosphate transport protein 1; Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Plays a role in urate transport in the kidney; Solute carriers	Solute carrier family 22 member 12; Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family	0.845
SLC17A1	SLC5A6	ENSP00000244527	ENSP00000310208	Sodium-dependent phosphate transport protein 1; Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Plays a role in urate transport in the kidney; Solute carriers	Sodium-dependent multivitamin transporter; Transports pantothenate, biotin and lipoate in the presence of sodium; Solute carriers	0.627
SLC22A12	SLC16A9	ENSP00000366797	ENSP00000378757	Solute carrier family 22 member 12; Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family	Monocarboxylate transporter 9; Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane; Solute carriers	0.708
SLC22A12	SLC17A1	ENSP00000366797	ENSP00000244527	Solute carrier family 22 member 12; Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family	Sodium-dependent phosphate transport protein 1; Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Plays a role in urate transport in the kidney; Solute carriers	0.845
SLC22A12	SLC5A6	ENSP00000366797	ENSP00000310208	Solute carrier family 22 member 12; Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family	Sodium-dependent multivitamin transporter; Transports pantothenate, biotin and lipoate in the presence of sodium; Solute carriers	0.550
SLC37A1	SLC16A5	ENSP00000344648	ENSP00000390564	Glucose-6-phosphate exchanger SLC37A1; Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6- phosphatase. May not play a role in homeostatic regulation of blood glucose levels; Belongs to the major facilitator superfamily. Organophosphate-Pi antiporter (OPA) (TC 2.A.1.4) family	Monocarboxylate transporter 6; Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity); Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family	0.550

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