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  • 11.0 [archived version]
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MAB21L2 MAB21L2 KLHL35 KLHL35 FOXP4 FOXP4 CYP2W1 CYP2W1 CDH22 CDH22 GPR146 GPR146 CEND1 CEND1 DEGS2 DEGS2 DLEU7 DLEU7 TOP1MT TOP1MT ADAM30 ADAM30
"CYP2W1" - Cytochrome P450 2W1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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CYP2W1Cytochrome P450 2W1; Seems to have broad catalytic activity towards several chemicals, including polycyclic aromatic hydrocarbon dihydrodiols and aromatic amines. Active also in the metabolism of indoline substrates and is able to activate aflatoxin B1 into cytotoxic products. Furthermore, it seems to be involved in the oxydation of lysophospholipids and fatty acids; Belongs to the cytochrome P450 family (490 aa)    
Predicted Functional Partners:
MAB21L2
Protein mab-21-like 2; Required for several aspects of embryonic development including normal development of the eye; Belongs to the mab-21 family (359 aa)
           
  0.685
KLHL35
Kelch-like protein 35; Kelch like family member 35; BTB domain containing (583 aa)
           
  0.676
GPR146
Probable G-protein coupled receptor 146; Orphan receptor; G protein-coupled receptors, Class A orphans (333 aa)
           
  0.640
DLEU7
Leukemia-associated protein 7; Deleted in lymphocytic leukemia, 7 (160 aa)
           
  0.591
ADAM30
Disintegrin and metalloproteinase domain-containing protein 30; Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP degradation; ADAM metallopeptidase domain containing (790 aa)
           
  0.584
FOXP4
Forkhead box protein P4; Transcriptional repressor that represses lung-specific expression; Forkhead boxes (680 aa)
       
 
  0.573
CDH22
Cadherin-22; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By similarity) (828 aa)
           
  0.573
TOP1MT
DNA topoisomerase I, mitochondrial; Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5’-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, [...] (601 aa)
           
  0.541
CEND1
Cell cycle exit and neuronal differentiation protein 1; Involved in neuronal differentiation; Belongs to the CEND1 family (149 aa)
           
  0.537
DEGS2
Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2; Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase; Fatty acid desaturases (323 aa)
           
  0.536
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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