| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C16orf93 | FAM53A | ENSP00000437532 | ENSP00000310057 | Coiled-coil domain-containing protein 189; Chromosome 16 open reading frame 93 | Protein FAM53A; May play an important role in neural development; the dorsomedial roof of the third ventricle | 0.669 |
| FAM53A | C16orf93 | ENSP00000310057 | ENSP00000437532 | Protein FAM53A; May play an important role in neural development; the dorsomedial roof of the third ventricle | Coiled-coil domain-containing protein 189; Chromosome 16 open reading frame 93 | 0.669 |
| FAM53A | FUT11 | ENSP00000310057 | ENSP00000361932 | Protein FAM53A; May play an important role in neural development; the dorsomedial roof of the third ventricle | Alpha-(1,3)-fucosyltransferase 11; Probable fucosyltransferase; Fucosyltransferases | 0.504 |
| FAM53A | INTS3 | ENSP00000310057 | ENSP00000318641 | Protein FAM53A; May play an important role in neural development; the dorsomedial roof of the third ventricle | Integrator complex subunit 3; Component of the Integrator (INT) complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3’-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex | 0.486 |
| FAM53A | INTS4 | ENSP00000310057 | ENSP00000434466 | Protein FAM53A; May play an important role in neural development; the dorsomedial roof of the third ventricle | Integrator complex subunit 4; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3’-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex; Armadillo-like helical domain containing | 0.504 |
| FAM53A | KIAA1683 | ENSP00000310057 | ENSP00000376213 | Protein FAM53A; May play an important role in neural development; the dorsomedial roof of the third ventricle | IQ domain-containing protein N; KIAA1683 | 0.543 |
| FAM53A | LETM1 | ENSP00000310057 | ENSP00000305653 | Protein FAM53A; May play an important role in neural development; the dorsomedial roof of the third ventricle | Mitochondrial proton/calcium exchanger protein; Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion. Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain. Required for the maintenance of the tubular shape and cristae organization. In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion; Belongs to the LETM1 family | 0.478 |
| FAM53A | SLBP | ENSP00000310057 | ENSP00000417686 | Protein FAM53A; May play an important role in neural development; the dorsomedial roof of the third ventricle | Histone RNA hairpin-binding protein; RNA-binding protein involved in the histone pre-mRNA processing. Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3’-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE). Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery. Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expressio [...] | 0.524 |
| FAM53A | SPATA2L | ENSP00000310057 | ENSP00000289805 | Protein FAM53A; May play an important role in neural development; the dorsomedial roof of the third ventricle | Spermatogenesis-associated protein 2-like protein; Spermatogenesis associated 2 like | 0.493 |
| FAM53A | TM2D1 | ENSP00000310057 | ENSP00000475700 | Protein FAM53A; May play an important role in neural development; the dorsomedial roof of the third ventricle | TM2 domain-containing protein 1; May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42 | 0.507 |
| FAM53A | TMEM129 | ENSP00000310057 | ENSP00000372394 | Protein FAM53A; May play an important role in neural development; the dorsomedial roof of the third ventricle | E3 ubiquitin-protein ligase TM129; E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Exploited by viral US11 proteins to mediate HLA class I proteins degradation | 0.696 |
| FUT11 | FAM53A | ENSP00000361932 | ENSP00000310057 | Alpha-(1,3)-fucosyltransferase 11; Probable fucosyltransferase; Fucosyltransferases | Protein FAM53A; May play an important role in neural development; the dorsomedial roof of the third ventricle | 0.504 |
| FUT11 | TM2D1 | ENSP00000361932 | ENSP00000475700 | Alpha-(1,3)-fucosyltransferase 11; Probable fucosyltransferase; Fucosyltransferases | TM2 domain-containing protein 1; May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42 | 0.530 |
| INTS3 | FAM53A | ENSP00000318641 | ENSP00000310057 | Integrator complex subunit 3; Component of the Integrator (INT) complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3’-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex | Protein FAM53A; May play an important role in neural development; the dorsomedial roof of the third ventricle | 0.486 |
| INTS3 | INTS4 | ENSP00000318641 | ENSP00000434466 | Integrator complex subunit 3; Component of the Integrator (INT) complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3’-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex | Integrator complex subunit 4; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3’-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex; Armadillo-like helical domain containing | 0.999 |
| INTS4 | FAM53A | ENSP00000434466 | ENSP00000310057 | Integrator complex subunit 4; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3’-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex; Armadillo-like helical domain containing | Protein FAM53A; May play an important role in neural development; the dorsomedial roof of the third ventricle | 0.504 |
| INTS4 | INTS3 | ENSP00000434466 | ENSP00000318641 | Integrator complex subunit 4; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3’-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex; Armadillo-like helical domain containing | Integrator complex subunit 3; Component of the Integrator (INT) complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3’-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex | 0.999 |
| KIAA1683 | FAM53A | ENSP00000376213 | ENSP00000310057 | IQ domain-containing protein N; KIAA1683 | Protein FAM53A; May play an important role in neural development; the dorsomedial roof of the third ventricle | 0.543 |
| LETM1 | FAM53A | ENSP00000305653 | ENSP00000310057 | Mitochondrial proton/calcium exchanger protein; Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion. Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain. Required for the maintenance of the tubular shape and cristae organization. In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion; Belongs to the LETM1 family | Protein FAM53A; May play an important role in neural development; the dorsomedial roof of the third ventricle | 0.478 |
| LETM1 | TMEM129 | ENSP00000305653 | ENSP00000372394 | Mitochondrial proton/calcium exchanger protein; Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion. Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain. Required for the maintenance of the tubular shape and cristae organization. In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion; Belongs to the LETM1 family | E3 ubiquitin-protein ligase TM129; E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Exploited by viral US11 proteins to mediate HLA class I proteins degradation | 0.450 |
