TBC1D16 protein (human) - STRING database

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TBC1D16

TBC1 domain family member 16; May act as a GTPase-activating protein for Rab family protein(s) (767 aa)

Predicted Functional Partners:

RAB4A

0.928

TBC1D19

0.567

VSIG2

0.559

FAM69A

0.557

WDR64

0.532

APMAP

0.527

TIMELESS

0.519

ARFGEF2

0.515

SGK2

0.512

PLCXD3

0.473

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APMAP	FAM69A	ENSP00000217456	ENSP00000359333	Adipocyte plasma membrane-associated protein; Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation; Belongs to the strictosidine synthase family	Protein FAM69A; Family with sequence similarity 69 member A	0.487
APMAP	TBC1D16	ENSP00000217456	ENSP00000309794	Adipocyte plasma membrane-associated protein; Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation; Belongs to the strictosidine synthase family	TBC1 domain family member 16; May act as a GTPase-activating protein for Rab family protein(s)	0.527
APMAP	VSIG2	ENSP00000217456	ENSP00000318684	Adipocyte plasma membrane-associated protein; Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation; Belongs to the strictosidine synthase family	V-set and immunoglobulin domain containing 2	0.488
ARFGEF2	TBC1D16	ENSP00000360985	ENSP00000309794	Brefeldin A-inhibited guanine nucleotide-exchange protein 2; Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma [...]	TBC1 domain family member 16; May act as a GTPase-activating protein for Rab family protein(s)	0.515
FAM69A	APMAP	ENSP00000359333	ENSP00000217456	Protein FAM69A; Family with sequence similarity 69 member A	Adipocyte plasma membrane-associated protein; Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation; Belongs to the strictosidine synthase family	0.487
FAM69A	SGK2	ENSP00000359333	ENSP00000340608	Protein FAM69A; Family with sequence similarity 69 member A	Serine/threonine-protein kinase Sgk2; Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up- regulates Na(+) channels- SCNN1A/ENAC, K(+) channels- KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter- SLC6A19, glutamate transporter- SLC1A6/EAAT4, glutamate receptors- GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger- SLC9A3/NHE3, and the Na(+)/K(+) ATPase	0.427
FAM69A	TBC1D16	ENSP00000359333	ENSP00000309794	Protein FAM69A; Family with sequence similarity 69 member A	TBC1 domain family member 16; May act as a GTPase-activating protein for Rab family protein(s)	0.557
FAM69A	VSIG2	ENSP00000359333	ENSP00000318684	Protein FAM69A; Family with sequence similarity 69 member A	V-set and immunoglobulin domain containing 2	0.570
PLCXD3	TBC1D16	ENSP00000367032	ENSP00000309794	PI-PLC X domain-containing protein 3; Phosphatidylinositol specific phospholipase C X domain containing 3	TBC1 domain family member 16; May act as a GTPase-activating protein for Rab family protein(s)	0.473
PLCXD3	WDR64	ENSP00000367032	ENSP00000355510	PI-PLC X domain-containing protein 3; Phosphatidylinositol specific phospholipase C X domain containing 3	WD repeat-containing protein 64; WD repeat domain containing	0.547
RAB4A	TBC1D16	ENSP00000355651	ENSP00000309794	Ras-related protein Rab-4A; Protein transport. Probably involved in vesicular traffic (By similarity); RAB, member RAS oncogene GTPases	TBC1 domain family member 16; May act as a GTPase-activating protein for Rab family protein(s)	0.928
SGK2	FAM69A	ENSP00000340608	ENSP00000359333	Serine/threonine-protein kinase Sgk2; Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up- regulates Na(+) channels- SCNN1A/ENAC, K(+) channels- KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter- SLC6A19, glutamate transporter- SLC1A6/EAAT4, glutamate receptors- GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger- SLC9A3/NHE3, and the Na(+)/K(+) ATPase	Protein FAM69A; Family with sequence similarity 69 member A	0.427
SGK2	TBC1D16	ENSP00000340608	ENSP00000309794	Serine/threonine-protein kinase Sgk2; Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up- regulates Na(+) channels- SCNN1A/ENAC, K(+) channels- KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter- SLC6A19, glutamate transporter- SLC1A6/EAAT4, glutamate receptors- GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger- SLC9A3/NHE3, and the Na(+)/K(+) ATPase	TBC1 domain family member 16; May act as a GTPase-activating protein for Rab family protein(s)	0.512
SGK2	VSIG2	ENSP00000340608	ENSP00000318684	Serine/threonine-protein kinase Sgk2; Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up- regulates Na(+) channels- SCNN1A/ENAC, K(+) channels- KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter- SLC6A19, glutamate transporter- SLC1A6/EAAT4, glutamate receptors- GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger- SLC9A3/NHE3, and the Na(+)/K(+) ATPase	V-set and immunoglobulin domain containing 2	0.463
TBC1D16	APMAP	ENSP00000309794	ENSP00000217456	TBC1 domain family member 16; May act as a GTPase-activating protein for Rab family protein(s)	Adipocyte plasma membrane-associated protein; Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation; Belongs to the strictosidine synthase family	0.527
TBC1D16	ARFGEF2	ENSP00000309794	ENSP00000360985	TBC1 domain family member 16; May act as a GTPase-activating protein for Rab family protein(s)	Brefeldin A-inhibited guanine nucleotide-exchange protein 2; Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma [...]	0.515
TBC1D16	FAM69A	ENSP00000309794	ENSP00000359333	TBC1 domain family member 16; May act as a GTPase-activating protein for Rab family protein(s)	Protein FAM69A; Family with sequence similarity 69 member A	0.557
TBC1D16	PLCXD3	ENSP00000309794	ENSP00000367032	TBC1 domain family member 16; May act as a GTPase-activating protein for Rab family protein(s)	PI-PLC X domain-containing protein 3; Phosphatidylinositol specific phospholipase C X domain containing 3	0.473
TBC1D16	RAB4A	ENSP00000309794	ENSP00000355651	TBC1 domain family member 16; May act as a GTPase-activating protein for Rab family protein(s)	Ras-related protein Rab-4A; Protein transport. Probably involved in vesicular traffic (By similarity); RAB, member RAS oncogene GTPases	0.928
TBC1D16	SGK2	ENSP00000309794	ENSP00000340608	TBC1 domain family member 16; May act as a GTPase-activating protein for Rab family protein(s)	Serine/threonine-protein kinase Sgk2; Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up- regulates Na(+) channels- SCNN1A/ENAC, K(+) channels- KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter- SLC6A19, glutamate transporter- SLC1A6/EAAT4, glutamate receptors- GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger- SLC9A3/NHE3, and the Na(+)/K(+) ATPase	0.512

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