LRCH4 protein (human) - STRING database

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Score

LRCH4

Leucine rich repeats and calponin homology domain containing 4 (683 aa)

Predicted Functional Partners:

LRCH3

0.876

DOCK8

0.853

LPHN3

0.683

LPHN1

0.683

LPHN2

0.683

ANKRD10

0.648

ANKRD46

0.625

RNF214

0.609

UFC1

0.604

FBXO24

0.596

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD10	ANKRD46	ENSP00000267339	ENSP00000429015	Ankyrin repeat domain-containing protein 10; Ankyrin repeat domain containing	Ankyrin repeat domain-containing protein 46; Ankyrin repeat domain containing	0.759
ANKRD10	FBXO24	ENSP00000267339	ENSP00000416558	Ankyrin repeat domain-containing protein 10; Ankyrin repeat domain containing	F-box only protein 24; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other	0.755
ANKRD10	LRCH4	ENSP00000267339	ENSP00000309689	Ankyrin repeat domain-containing protein 10; Ankyrin repeat domain containing	Leucine rich repeats and calponin homology domain containing 4	0.648
ANKRD10	RNF214	ENSP00000267339	ENSP00000300650	Ankyrin repeat domain-containing protein 10; Ankyrin repeat domain containing	Ring finger protein 214	0.780
ANKRD46	ANKRD10	ENSP00000429015	ENSP00000267339	Ankyrin repeat domain-containing protein 46; Ankyrin repeat domain containing	Ankyrin repeat domain-containing protein 10; Ankyrin repeat domain containing	0.759
ANKRD46	FBXO24	ENSP00000429015	ENSP00000416558	Ankyrin repeat domain-containing protein 46; Ankyrin repeat domain containing	F-box only protein 24; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other	0.780
ANKRD46	LRCH4	ENSP00000429015	ENSP00000309689	Ankyrin repeat domain-containing protein 46; Ankyrin repeat domain containing	Leucine rich repeats and calponin homology domain containing 4	0.625
ANKRD46	RNF214	ENSP00000429015	ENSP00000300650	Ankyrin repeat domain-containing protein 46; Ankyrin repeat domain containing	Ring finger protein 214	0.759
DOCK8	LRCH3	ENSP00000394888	ENSP00000334375	Dedicator of cytokinesis protein 8; Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC (By similarity). Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane. Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CC [...]	Leucine rich repeats and calponin homology domain containing 3	0.863
DOCK8	LRCH4	ENSP00000394888	ENSP00000309689	Dedicator of cytokinesis protein 8; Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC (By similarity). Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane. Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CC [...]	Leucine rich repeats and calponin homology domain containing 4	0.853
FBXO24	ANKRD10	ENSP00000416558	ENSP00000267339	F-box only protein 24; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other	Ankyrin repeat domain-containing protein 10; Ankyrin repeat domain containing	0.755
FBXO24	ANKRD46	ENSP00000416558	ENSP00000429015	F-box only protein 24; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other	Ankyrin repeat domain-containing protein 46; Ankyrin repeat domain containing	0.780
FBXO24	LRCH4	ENSP00000416558	ENSP00000309689	F-box only protein 24; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other	Leucine rich repeats and calponin homology domain containing 4	0.596
FBXO24	RNF214	ENSP00000416558	ENSP00000300650	F-box only protein 24; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other	Ring finger protein 214	0.745
LPHN1	LRCH3	ENSP00000340688	ENSP00000334375	Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity)	Leucine rich repeats and calponin homology domain containing 3	0.683
LPHN1	LRCH4	ENSP00000340688	ENSP00000309689	Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity)	Leucine rich repeats and calponin homology domain containing 4	0.683
LPHN2	LRCH3	ENSP00000322270	ENSP00000334375	Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily	Leucine rich repeats and calponin homology domain containing 3	0.683
LPHN2	LRCH4	ENSP00000322270	ENSP00000309689	Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily	Leucine rich repeats and calponin homology domain containing 4	0.683
LPHN3	LRCH3	ENSP00000422533	ENSP00000334375	Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily	Leucine rich repeats and calponin homology domain containing 3	0.683
LPHN3	LRCH4	ENSP00000422533	ENSP00000309689	Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily	Leucine rich repeats and calponin homology domain containing 4	0.683

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