• Version:
  • 11.0 [archived version]
STRINGSTRING
NEK1 NEK1 SPEM1 SPEM1 MBIP MBIP SPATA3 SPATA3 SPATA4 SPATA4 CBY3 CBY3 SPERT SPERT MAGEE2 MAGEE2 ZNF80 ZNF80 FAM187B FAM187B EFCAB13 EFCAB13
"SPERT" - Spermatid-associated protein in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPERTSpermatid-associated protein; Spermatid associated (448 aa)    
Predicted Functional Partners:
CBY3
Chibby family member 3 (242 aa)
           
  0.725
NEK1
Serine/threonine-protein kinase Nek1; Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (By similarity). Involved in DNA damage checkpoint control and for proper DNA damage repair. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death. May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (1286 aa)
           
  0.691
SPATA3
Spermatogenesis-associated protein 3; Spermatogenesis associated 3 (192 aa)
     
   
  0.673
SPEM1
Spermatid maturation protein 1; Required for proper cytoplasm removal during spermatogenesis (309 aa)
     
   
  0.634
FAM187B
Protein FAM187B; Family with sequence similarity 187 member B (369 aa)
           
  0.613
EFCAB13
EF-hand calcium-binding domain-containing protein 13; EF-hand calcium binding domain 13 (973 aa)
           
  0.585
MBIP
MAP3K12-binding inhibitory protein 1; Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (344 aa)
       
      0.571
ZNF80
Zinc finger protein 80; May be involved in transcriptional regulation; Zinc fingers C2H2-type (273 aa)
           
  0.564
MAGEE2
Melanoma-associated antigen E2; MAGE family member E2 (523 aa)
     
   
  0.561
SPATA4
Spermatogenesis-associated protein 4; Spermatogenesis associated 4 (305 aa)
     
   
  0.558
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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