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  • 11.0 [archived version]
STRINGSTRING
TATDN3 TATDN3 PFDN4 PFDN4 HMG20A HMG20A PFDN6 PFDN6 NEDD8 NEDD8 FAM81B FAM81B EIF1AD EIF1AD ENKUR ENKUR TMEM106A TMEM106A PKNOX2 PKNOX2 GLTPD2 GLTPD2
"EIF1AD" - Probable RNA-binding protein EIF1AD in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
EIF1ADProbable RNA-binding protein EIF1AD; Plays a role into cellular response to oxidative stress. Decreases cell proliferation (165 aa)    
Predicted Functional Partners:
TATDN3
Putative deoxyribonuclease TATDN3; Putative deoxyribonuclease; Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family (281 aa)
           
  0.771
FAM81B
Protein FAM81B; Family with sequence similarity 81 member B (452 aa)
           
  0.601
GLTPD2
Glycolipid transfer protein domain containing 2; Belongs to the GLTP family (291 aa)
           
  0.579
NEDD8
NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C- APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (81 aa)
     
        0.575
PFDN6
Prefoldin subunit 6; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Prefoldin subunits (129 aa)
     
   
  0.551
ENKUR
Enkurin; Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel; Cilia and flagella associated (256 aa)
           
  0.545
TMEM106A
Transmembrane protein 106A; Belongs to the TMEM106 family (262 aa)
           
  0.539
PFDN4
Prefoldin subunit 4; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit beta family (134 aa)
     
   
  0.532
PKNOX2
Homeobox protein PKNOX2; TALE class homeoboxes and pseudogenes; Belongs to the TALE/MEIS homeobox family (472 aa)
           
  0.507
HMG20A
High mobility group protein 20A; Plays a role in neuronal differentiation as chromatin- associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4 (By similarity); Non-canonical high mobility group (347 aa)
     
   
  0.507
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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