| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADAM10 | TSPAN12 | ENSP00000260408 | ENSP00000222747 | Disintegrin and metalloproteinase domain-containing protein 10; Cleaves the membrane-bound precursor of TNF-alpha at ’76-Ala-|-Val-77’ to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cle [...] | Tetraspanin-12; Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also p [...] | 0.670 |
| ADAM10 | TSPAN17 | ENSP00000260408 | ENSP00000309036 | Disintegrin and metalloproteinase domain-containing protein 10; Cleaves the membrane-bound precursor of TNF-alpha at ’76-Ala-|-Val-77’ to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cle [...] | Tetraspanin-17; Regulates ADAM10 maturation; Belongs to the tetraspanin (TM4SF) family | 0.748 |
| EFCAB13 | TSPAN17 | ENSP00000332111 | ENSP00000309036 | EF-hand calcium-binding domain-containing protein 13; EF-hand calcium binding domain 13 | Tetraspanin-17; Regulates ADAM10 maturation; Belongs to the tetraspanin (TM4SF) family | 0.521 |
| METAP1 | SNCB | ENSP00000296411 | ENSP00000308057 | Methionine aminopeptidase 1; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily | Beta-synuclein; Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53- dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease | 0.521 |
| METAP1 | TSPAN17 | ENSP00000296411 | ENSP00000309036 | Methionine aminopeptidase 1; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily | Tetraspanin-17; Regulates ADAM10 maturation; Belongs to the tetraspanin (TM4SF) family | 0.626 |
| PACSIN3 | TSPAN17 | ENSP00000440945 | ENSP00000309036 | Protein kinase C and casein kinase substrate in neurons protein 3; Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity); F-BAR domain containing | Tetraspanin-17; Regulates ADAM10 maturation; Belongs to the tetraspanin (TM4SF) family | 0.547 |
| PACSIN3 | TSPAN31 | ENSP00000440945 | ENSP00000257910 | Protein kinase C and casein kinase substrate in neurons protein 3; Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity); F-BAR domain containing | Tetraspanin-31; Tetraspanin 31; Tetraspanins | 0.436 |
| SC5D | TSPAN17 | ENSP00000264027 | ENSP00000309036 | Lathosterol oxidase; Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol; Belongs to the sterol desaturase family | Tetraspanin-17; Regulates ADAM10 maturation; Belongs to the tetraspanin (TM4SF) family | 0.522 |
| SNCB | METAP1 | ENSP00000308057 | ENSP00000296411 | Beta-synuclein; Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53- dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease | Methionine aminopeptidase 1; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily | 0.521 |
| SNCB | TSPAN17 | ENSP00000308057 | ENSP00000309036 | Beta-synuclein; Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53- dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease | Tetraspanin-17; Regulates ADAM10 maturation; Belongs to the tetraspanin (TM4SF) family | 0.518 |
| TSPAN12 | ADAM10 | ENSP00000222747 | ENSP00000260408 | Tetraspanin-12; Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also p [...] | Disintegrin and metalloproteinase domain-containing protein 10; Cleaves the membrane-bound precursor of TNF-alpha at ’76-Ala-|-Val-77’ to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cle [...] | 0.670 |
| TSPAN12 | TSPAN17 | ENSP00000222747 | ENSP00000309036 | Tetraspanin-12; Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also p [...] | Tetraspanin-17; Regulates ADAM10 maturation; Belongs to the tetraspanin (TM4SF) family | 0.757 |
| TSPAN13 | TSPAN17 | ENSP00000262067 | ENSP00000309036 | Tetraspanin-13; Tetraspanin 13; Tetraspanins | Tetraspanin-17; Regulates ADAM10 maturation; Belongs to the tetraspanin (TM4SF) family | 0.576 |
| TSPAN13 | TSPAN32 | ENSP00000262067 | ENSP00000182290 | Tetraspanin-13; Tetraspanin 13; Tetraspanins | Tetraspanin-32; Tetraspanin 32; Belongs to the tetraspanin (TM4SF) family | 0.565 |
| TSPAN17 | ADAM10 | ENSP00000309036 | ENSP00000260408 | Tetraspanin-17; Regulates ADAM10 maturation; Belongs to the tetraspanin (TM4SF) family | Disintegrin and metalloproteinase domain-containing protein 10; Cleaves the membrane-bound precursor of TNF-alpha at ’76-Ala-|-Val-77’ to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cle [...] | 0.748 |
| TSPAN17 | EFCAB13 | ENSP00000309036 | ENSP00000332111 | Tetraspanin-17; Regulates ADAM10 maturation; Belongs to the tetraspanin (TM4SF) family | EF-hand calcium-binding domain-containing protein 13; EF-hand calcium binding domain 13 | 0.521 |
| TSPAN17 | METAP1 | ENSP00000309036 | ENSP00000296411 | Tetraspanin-17; Regulates ADAM10 maturation; Belongs to the tetraspanin (TM4SF) family | Methionine aminopeptidase 1; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily | 0.626 |
| TSPAN17 | PACSIN3 | ENSP00000309036 | ENSP00000440945 | Tetraspanin-17; Regulates ADAM10 maturation; Belongs to the tetraspanin (TM4SF) family | Protein kinase C and casein kinase substrate in neurons protein 3; Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity); F-BAR domain containing | 0.547 |
| TSPAN17 | SC5D | ENSP00000309036 | ENSP00000264027 | Tetraspanin-17; Regulates ADAM10 maturation; Belongs to the tetraspanin (TM4SF) family | Lathosterol oxidase; Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol; Belongs to the sterol desaturase family | 0.522 |
| TSPAN17 | SNCB | ENSP00000309036 | ENSP00000308057 | Tetraspanin-17; Regulates ADAM10 maturation; Belongs to the tetraspanin (TM4SF) family | Beta-synuclein; Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53- dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease | 0.518 |
