| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARL15 | SKIDA1 | ENSP00000433427 | ENSP00000410041 | ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; ARF GTPase family | SKI/DACH domain containing 1 | 0.676 |
| ARL15 | VWC2L | ENSP00000433427 | ENSP00000308976 | ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; ARF GTPase family | Von Willebrand factor C domain-containing protein 2-like; May play a role in neurogenesis. May play a role in bone differentiation and matrix mineralization | 0.610 |
| BARD1 | VWC2L | ENSP00000260947 | ENSP00000308976 | BRCA1-associated RING domain protein 1; E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of ’Lys-6’-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II [...] | Von Willebrand factor C domain-containing protein 2-like; May play a role in neurogenesis. May play a role in bone differentiation and matrix mineralization | 0.677 |
| CPAMD8 | ESYT2 | ENSP00000402505 | ENSP00000251527 | C3 and PZP like, alpha-2-macroglobulin domain containing 8; Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family | Extended synaptotagmin-2; Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex; Extended synaptotagmins | 0.506 |
| CPAMD8 | VWC2L | ENSP00000402505 | ENSP00000308976 | C3 and PZP like, alpha-2-macroglobulin domain containing 8; Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family | Von Willebrand factor C domain-containing protein 2-like; May play a role in neurogenesis. May play a role in bone differentiation and matrix mineralization | 0.678 |
| CPAMD8 | WDR60 | ENSP00000402505 | ENSP00000384290 | C3 and PZP like, alpha-2-macroglobulin domain containing 8; Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family | WD repeat-containing protein 60; May play a role in ciliogenesis; WD repeat domain containing | 0.539 |
| ESYT2 | CPAMD8 | ENSP00000251527 | ENSP00000402505 | Extended synaptotagmin-2; Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex; Extended synaptotagmins | C3 and PZP like, alpha-2-macroglobulin domain containing 8; Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family | 0.506 |
| ESYT2 | VWC2L | ENSP00000251527 | ENSP00000308976 | Extended synaptotagmin-2; Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex; Extended synaptotagmins | Von Willebrand factor C domain-containing protein 2-like; May play a role in neurogenesis. May play a role in bone differentiation and matrix mineralization | 0.686 |
| ESYT2 | WDR60 | ENSP00000251527 | ENSP00000384290 | Extended synaptotagmin-2; Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex; Extended synaptotagmins | WD repeat-containing protein 60; May play a role in ciliogenesis; WD repeat domain containing | 0.690 |
| PORCN | SHISA6 | ENSP00000322304 | ENSP00000390084 | Protein-serine O-palmitoleoyltransferase porcupine; Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16-1), to Wnt proteins. Serine palmitoleylation of WNT proteins is required for efficient binding to frizzled receptors; Membrane bound O-acyltransferases | Protein shisa-6 homolog; Shisa family member 6 | 0.581 |
| PORCN | SHISA9 | ENSP00000322304 | ENSP00000454014 | Protein-serine O-palmitoleoyltransferase porcupine; Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16-1), to Wnt proteins. Serine palmitoleylation of WNT proteins is required for efficient binding to frizzled receptors; Membrane bound O-acyltransferases | Protein shisa-9; Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses (By similarity); Belongs to the shisa family. SHISA9 subfamily | 0.609 |
| PORCN | VWC2L | ENSP00000322304 | ENSP00000308976 | Protein-serine O-palmitoleoyltransferase porcupine; Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16-1), to Wnt proteins. Serine palmitoleylation of WNT proteins is required for efficient binding to frizzled receptors; Membrane bound O-acyltransferases | Von Willebrand factor C domain-containing protein 2-like; May play a role in neurogenesis. May play a role in bone differentiation and matrix mineralization | 0.623 |
| SHISA6 | PORCN | ENSP00000390084 | ENSP00000322304 | Protein shisa-6 homolog; Shisa family member 6 | Protein-serine O-palmitoleoyltransferase porcupine; Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16-1), to Wnt proteins. Serine palmitoleylation of WNT proteins is required for efficient binding to frizzled receptors; Membrane bound O-acyltransferases | 0.581 |
| SHISA6 | SHISA9 | ENSP00000390084 | ENSP00000454014 | Protein shisa-6 homolog; Shisa family member 6 | Protein shisa-9; Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses (By similarity); Belongs to the shisa family. SHISA9 subfamily | 0.612 |
| SHISA6 | VWC2L | ENSP00000390084 | ENSP00000308976 | Protein shisa-6 homolog; Shisa family member 6 | Von Willebrand factor C domain-containing protein 2-like; May play a role in neurogenesis. May play a role in bone differentiation and matrix mineralization | 0.785 |
| SHISA9 | PORCN | ENSP00000454014 | ENSP00000322304 | Protein shisa-9; Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses (By similarity); Belongs to the shisa family. SHISA9 subfamily | Protein-serine O-palmitoleoyltransferase porcupine; Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16-1), to Wnt proteins. Serine palmitoleylation of WNT proteins is required for efficient binding to frizzled receptors; Membrane bound O-acyltransferases | 0.609 |
| SHISA9 | SHISA6 | ENSP00000454014 | ENSP00000390084 | Protein shisa-9; Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses (By similarity); Belongs to the shisa family. SHISA9 subfamily | Protein shisa-6 homolog; Shisa family member 6 | 0.612 |
| SHISA9 | VWC2L | ENSP00000454014 | ENSP00000308976 | Protein shisa-9; Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses (By similarity); Belongs to the shisa family. SHISA9 subfamily | Von Willebrand factor C domain-containing protein 2-like; May play a role in neurogenesis. May play a role in bone differentiation and matrix mineralization | 0.689 |
| SKIDA1 | ARL15 | ENSP00000410041 | ENSP00000433427 | SKI/DACH domain containing 1 | ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; ARF GTPase family | 0.676 |
| SKIDA1 | VWC2L | ENSP00000410041 | ENSP00000308976 | SKI/DACH domain containing 1 | Von Willebrand factor C domain-containing protein 2-like; May play a role in neurogenesis. May play a role in bone differentiation and matrix mineralization | 0.688 |
