node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENOPH1 | PPM1J | ENSP00000273920 | ENSP00000308926 | Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene); HAD Asp-based non-protein phosphatases | Protein phosphatase, Mg2+/Mn2+ dependent 1J | 0.526 |
IRGQ | PPM1J | ENSP00000387535 | ENSP00000308926 | Immunity-related GTPase family Q protein; Immunity related GTPase Q; Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family | Protein phosphatase, Mg2+/Mn2+ dependent 1J | 0.564 |
PDP1 | PPM1A | ENSP00000379503 | ENSP00000327255 | [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex; Belongs to the PP2C family | Protein phosphatase 1A; Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB; Belongs to the PP2C family | 0.598 |
PDP1 | PPM1E | ENSP00000379503 | ENSP00000312411 | [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex; Belongs to the PP2C family | Protein phosphatase 1E; Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42. Dephosphorylates PRKAA2 (By similarity); Protein phosphatases, Mg2+/Mn2+ dependent | 0.485 |
PDP1 | PPM1J | ENSP00000379503 | ENSP00000308926 | [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex; Belongs to the PP2C family | Protein phosphatase, Mg2+/Mn2+ dependent 1J | 0.672 |
PDP1 | PPM1K | ENSP00000379503 | ENSP00000477341 | [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex; Belongs to the PP2C family | Protein phosphatase 1K, mitochondrial; Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development; Belongs to the PP2C family | 0.512 |
PDP1 | PPTC7 | ENSP00000379503 | ENSP00000346255 | [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex; Belongs to the PP2C family | PTC7 protein phosphatase homolog | 0.894 |
PPM1A | PDP1 | ENSP00000327255 | ENSP00000379503 | Protein phosphatase 1A; Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB; Belongs to the PP2C family | [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex; Belongs to the PP2C family | 0.598 |
PPM1A | PPM1J | ENSP00000327255 | ENSP00000308926 | Protein phosphatase 1A; Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB; Belongs to the PP2C family | Protein phosphatase, Mg2+/Mn2+ dependent 1J | 0.562 |
PPM1A | PPTC7 | ENSP00000327255 | ENSP00000346255 | Protein phosphatase 1A; Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB; Belongs to the PP2C family | PTC7 protein phosphatase homolog | 0.747 |
PPM1E | PDP1 | ENSP00000312411 | ENSP00000379503 | Protein phosphatase 1E; Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42. Dephosphorylates PRKAA2 (By similarity); Protein phosphatases, Mg2+/Mn2+ dependent | [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex; Belongs to the PP2C family | 0.485 |
PPM1E | PPM1J | ENSP00000312411 | ENSP00000308926 | Protein phosphatase 1E; Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42. Dephosphorylates PRKAA2 (By similarity); Protein phosphatases, Mg2+/Mn2+ dependent | Protein phosphatase, Mg2+/Mn2+ dependent 1J | 0.615 |
PPM1E | PPTC7 | ENSP00000312411 | ENSP00000346255 | Protein phosphatase 1E; Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42. Dephosphorylates PRKAA2 (By similarity); Protein phosphatases, Mg2+/Mn2+ dependent | PTC7 protein phosphatase homolog | 0.581 |
PPM1J | ENOPH1 | ENSP00000308926 | ENSP00000273920 | Protein phosphatase, Mg2+/Mn2+ dependent 1J | Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene); HAD Asp-based non-protein phosphatases | 0.526 |
PPM1J | IRGQ | ENSP00000308926 | ENSP00000387535 | Protein phosphatase, Mg2+/Mn2+ dependent 1J | Immunity-related GTPase family Q protein; Immunity related GTPase Q; Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family | 0.564 |
PPM1J | PDP1 | ENSP00000308926 | ENSP00000379503 | Protein phosphatase, Mg2+/Mn2+ dependent 1J | [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex; Belongs to the PP2C family | 0.672 |
PPM1J | PPM1A | ENSP00000308926 | ENSP00000327255 | Protein phosphatase, Mg2+/Mn2+ dependent 1J | Protein phosphatase 1A; Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB; Belongs to the PP2C family | 0.562 |
PPM1J | PPM1E | ENSP00000308926 | ENSP00000312411 | Protein phosphatase, Mg2+/Mn2+ dependent 1J | Protein phosphatase 1E; Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42. Dephosphorylates PRKAA2 (By similarity); Protein phosphatases, Mg2+/Mn2+ dependent | 0.615 |
PPM1J | PPM1K | ENSP00000308926 | ENSP00000477341 | Protein phosphatase, Mg2+/Mn2+ dependent 1J | Protein phosphatase 1K, mitochondrial; Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development; Belongs to the PP2C family | 0.550 |
PPM1J | PPTC7 | ENSP00000308926 | ENSP00000346255 | Protein phosphatase, Mg2+/Mn2+ dependent 1J | PTC7 protein phosphatase homolog | 0.735 |