• Version:
  • 11.0 [archived version]
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ZCCHC5 ZCCHC5 SMAD1 SMAD1 RGAG4 RGAG4 RGAG1 RGAG1 PNMAL1 PNMAL1 SUMO1 SUMO1 ZCCHC12 ZCCHC12 CDR2L CDR2L PNMA1 PNMA1 LAMA4 LAMA4 LAMA3 LAMA3
"ZCCHC12" - Zinc finger CCHC domain-containing protein 12 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ZCCHC12Zinc finger CCHC domain-containing protein 12; Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression (By similarity); Paraneoplastic Ma antigens (402 aa)    
Predicted Functional Partners:
CDR2L
Cerebellar degeneration related protein 2 like (465 aa)
     
   
  0.932
PNMAL1
Paraneoplastic antigen-like protein 8A; Paraneoplastic Ma antigen family-like 1 (439 aa)
     
   
  0.687
RGAG1
Retrotransposon Gag-like protein 9; Retrotransposon gag domain containing 1 (1388 aa)
     
   
  0.617
RGAG4
Retrotransposon Gag-like protein 5; Retrotransposon gag domain containing 4 (569 aa)
     
   
  0.594
SMAD1
Mothers against decapentaplegic homolog 1; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression; Belongs to the dwarfin/SMAD family (465 aa)
       
 
  0.583
ZCCHC5
Retrotransposon Gag-like protein 3; May function as a transcriptional regulator. Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (475 aa)
           
  0.561
LAMA3
Laminin subunit alpha-3; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components (3333 aa)
           
  0.559
LAMA4
Laminin subunit alpha-4; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components (1823 aa)
           
  0.551
SUMO1
Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instan [...] (101 aa)
       
 
  0.540
PNMA1
Paraneoplastic Ma antigens; Belongs to the PNMA family (353 aa)
     
   
0.533
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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