GPR148 protein (human) - STRING database

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Score

GPR148

Probable G-protein coupled receptor 148; Orphan receptor; G protein-coupled receptors, Class A orphans (347 aa)

Predicted Functional Partners:

RMI1

0.786

RMI2

0.781

GPR141

0.774

GPR139

0.737

GPR111

0.697

GPR110

0.672

GEN1

0.659

SLX1A

0.655

SLX1B

0.654

MUS81

0.585

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GEN1	GPR148	ENSP00000318977	ENSP00000308908	Flap endonuclease GEN homolog 1; Endonuclease which resolves Holliday junctions by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation	Probable G-protein coupled receptor 148; Orphan receptor; G protein-coupled receptors, Class A orphans	0.659
GEN1	MUS81	ENSP00000318977	ENSP00000307853	Flap endonuclease GEN homolog 1; Endonuclease which resolves Holliday junctions by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation	Crossover junction endonuclease MUS81; Interacts with EME1 and EME2 to form a DNA structure- specific endonuclease with substrate preference for branched DNA structures with a 5’-end at the branch nick. Typical substrates include 3’-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks; Belongs to the XPF family	0.936
GEN1	RMI1	ENSP00000318977	ENSP00000317039	Flap endonuclease GEN homolog 1; Endonuclease which resolves Holliday junctions by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation	RecQ-mediated genome instability protein 1; Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability; Belongs to the RMI1 family	0.975
GEN1	RMI2	ENSP00000318977	ENSP00000310356	Flap endonuclease GEN homolog 1; Endonuclease which resolves Holliday junctions by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation	RecQ-mediated genome instability protein 2; Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM	0.979
GEN1	SLX1A	ENSP00000318977	ENSP00000251303	Flap endonuclease GEN homolog 1; Endonuclease which resolves Holliday junctions by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation	SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae); Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5’-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products	0.887
GEN1	SLX1B	ENSP00000318977	ENSP00000328940	Flap endonuclease GEN homolog 1; Endonuclease which resolves Holliday junctions by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5’-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products	0.887
GPR110	GPR139	ENSP00000360299	ENSP00000458791	Adhesion G-protein coupled receptor F1; Orphan receptor; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily	Probable G-protein coupled receptor 139; Orphan receptor. Seems to act through a G(q/11)-mediated pathway; G protein-coupled receptors, Class A orphans	0.716
GPR110	GPR141	ENSP00000360299	ENSP00000390410	Adhesion G-protein coupled receptor F1; Orphan receptor; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily	Probable G-protein coupled receptor 141; Orphan receptor; G protein-coupled receptors, Class A orphans	0.721
GPR110	GPR148	ENSP00000360299	ENSP00000308908	Adhesion G-protein coupled receptor F1; Orphan receptor; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily	Probable G-protein coupled receptor 148; Orphan receptor; G protein-coupled receptors, Class A orphans	0.672
GPR111	GPR139	ENSP00000296862	ENSP00000458791	Adhesion G-protein coupled receptor F2; Orphan receptor	Probable G-protein coupled receptor 139; Orphan receptor. Seems to act through a G(q/11)-mediated pathway; G protein-coupled receptors, Class A orphans	0.726
GPR111	GPR141	ENSP00000296862	ENSP00000390410	Adhesion G-protein coupled receptor F2; Orphan receptor	Probable G-protein coupled receptor 141; Orphan receptor; G protein-coupled receptors, Class A orphans	0.726
GPR111	GPR148	ENSP00000296862	ENSP00000308908	Adhesion G-protein coupled receptor F2; Orphan receptor	Probable G-protein coupled receptor 148; Orphan receptor; G protein-coupled receptors, Class A orphans	0.697
GPR139	GPR110	ENSP00000458791	ENSP00000360299	Probable G-protein coupled receptor 139; Orphan receptor. Seems to act through a G(q/11)-mediated pathway; G protein-coupled receptors, Class A orphans	Adhesion G-protein coupled receptor F1; Orphan receptor; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily	0.716
GPR139	GPR111	ENSP00000458791	ENSP00000296862	Probable G-protein coupled receptor 139; Orphan receptor. Seems to act through a G(q/11)-mediated pathway; G protein-coupled receptors, Class A orphans	Adhesion G-protein coupled receptor F2; Orphan receptor	0.726
GPR139	GPR141	ENSP00000458791	ENSP00000390410	Probable G-protein coupled receptor 139; Orphan receptor. Seems to act through a G(q/11)-mediated pathway; G protein-coupled receptors, Class A orphans	Probable G-protein coupled receptor 141; Orphan receptor; G protein-coupled receptors, Class A orphans	0.759
GPR139	GPR148	ENSP00000458791	ENSP00000308908	Probable G-protein coupled receptor 139; Orphan receptor. Seems to act through a G(q/11)-mediated pathway; G protein-coupled receptors, Class A orphans	Probable G-protein coupled receptor 148; Orphan receptor; G protein-coupled receptors, Class A orphans	0.737
GPR141	GPR110	ENSP00000390410	ENSP00000360299	Probable G-protein coupled receptor 141; Orphan receptor; G protein-coupled receptors, Class A orphans	Adhesion G-protein coupled receptor F1; Orphan receptor; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily	0.721
GPR141	GPR111	ENSP00000390410	ENSP00000296862	Probable G-protein coupled receptor 141; Orphan receptor; G protein-coupled receptors, Class A orphans	Adhesion G-protein coupled receptor F2; Orphan receptor	0.726
GPR141	GPR139	ENSP00000390410	ENSP00000458791	Probable G-protein coupled receptor 141; Orphan receptor; G protein-coupled receptors, Class A orphans	Probable G-protein coupled receptor 139; Orphan receptor. Seems to act through a G(q/11)-mediated pathway; G protein-coupled receptors, Class A orphans	0.759
GPR141	GPR148	ENSP00000390410	ENSP00000308908	Probable G-protein coupled receptor 141; Orphan receptor; G protein-coupled receptors, Class A orphans	Probable G-protein coupled receptor 148; Orphan receptor; G protein-coupled receptors, Class A orphans	0.774

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