SNED1 protein (human) - STRING database

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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SNED1

Sushi, nidogen and EGF-like domain-containing protein 1; Fibronectin type III domain containing (1413 aa)

Predicted Functional Partners:

SSTR2

0.788

SST

0.788

SSTR1

0.775

SSTR4

0.768

SSTR3

0.763

SSTR5

0.739

THAP4

0.626

C2orf54

0.625

ANKMY1

0.622

FARP2

0.587

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKMY1	C2orf54	ENSP00000385887	ENSP00000373586	Ankyrin repeat and MYND domain containing 1	Uncharacterized protein C2orf54; Chromosome 2 open reading frame 54	0.697
ANKMY1	FARP2	ENSP00000385887	ENSP00000264042	Ankyrin repeat and MYND domain containing 1	FERM, ARHGEF and pleckstrin domain-containing protein 2; Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity); FERM domain containing	0.602
ANKMY1	SNED1	ENSP00000385887	ENSP00000308893	Ankyrin repeat and MYND domain containing 1	Sushi, nidogen and EGF-like domain-containing protein 1; Fibronectin type III domain containing	0.622
ANKMY1	THAP4	ENSP00000385887	ENSP00000385006	Ankyrin repeat and MYND domain containing 1	THAP domain containing 4	0.709
C2orf54	ANKMY1	ENSP00000373586	ENSP00000385887	Uncharacterized protein C2orf54; Chromosome 2 open reading frame 54	Ankyrin repeat and MYND domain containing 1	0.697
C2orf54	FARP2	ENSP00000373586	ENSP00000264042	Uncharacterized protein C2orf54; Chromosome 2 open reading frame 54	FERM, ARHGEF and pleckstrin domain-containing protein 2; Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity); FERM domain containing	0.611
C2orf54	SNED1	ENSP00000373586	ENSP00000308893	Uncharacterized protein C2orf54; Chromosome 2 open reading frame 54	Sushi, nidogen and EGF-like domain-containing protein 1; Fibronectin type III domain containing	0.625
C2orf54	THAP4	ENSP00000373586	ENSP00000385006	Uncharacterized protein C2orf54; Chromosome 2 open reading frame 54	THAP domain containing 4	0.707
FARP2	ANKMY1	ENSP00000264042	ENSP00000385887	FERM, ARHGEF and pleckstrin domain-containing protein 2; Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity); FERM domain containing	Ankyrin repeat and MYND domain containing 1	0.602
FARP2	C2orf54	ENSP00000264042	ENSP00000373586	FERM, ARHGEF and pleckstrin domain-containing protein 2; Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity); FERM domain containing	Uncharacterized protein C2orf54; Chromosome 2 open reading frame 54	0.611
FARP2	SNED1	ENSP00000264042	ENSP00000308893	FERM, ARHGEF and pleckstrin domain-containing protein 2; Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity); FERM domain containing	Sushi, nidogen and EGF-like domain-containing protein 1; Fibronectin type III domain containing	0.587
FARP2	THAP4	ENSP00000264042	ENSP00000385006	FERM, ARHGEF and pleckstrin domain-containing protein 2; Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity); FERM domain containing	THAP domain containing 4	0.620
SNED1	ANKMY1	ENSP00000308893	ENSP00000385887	Sushi, nidogen and EGF-like domain-containing protein 1; Fibronectin type III domain containing	Ankyrin repeat and MYND domain containing 1	0.622
SNED1	C2orf54	ENSP00000308893	ENSP00000373586	Sushi, nidogen and EGF-like domain-containing protein 1; Fibronectin type III domain containing	Uncharacterized protein C2orf54; Chromosome 2 open reading frame 54	0.625
SNED1	FARP2	ENSP00000308893	ENSP00000264042	Sushi, nidogen and EGF-like domain-containing protein 1; Fibronectin type III domain containing	FERM, ARHGEF and pleckstrin domain-containing protein 2; Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity); FERM domain containing	0.587
SNED1	SST	ENSP00000308893	ENSP00000287641	Sushi, nidogen and EGF-like domain-containing protein 1; Fibronectin type III domain containing	Somatostatin; Somatostatin inhibits the release of somatotropin; Endogenous ligands	0.788
SNED1	SSTR1	ENSP00000308893	ENSP00000267377	Sushi, nidogen and EGF-like domain-containing protein 1; Fibronectin type III domain containing	Somatostatin receptor type 1; Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins	0.775
SNED1	SSTR2	ENSP00000308893	ENSP00000350198	Sushi, nidogen and EGF-like domain-containing protein 1; Fibronectin type III domain containing	Somatostatin receptor type 2; Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 [...]	0.788
SNED1	SSTR3	ENSP00000308893	ENSP00000480971	Sushi, nidogen and EGF-like domain-containing protein 1; Fibronectin type III domain containing	Somatostatin receptor type 3; Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase	0.763
SNED1	SSTR4	ENSP00000308893	ENSP00000255008	Sushi, nidogen and EGF-like domain-containing protein 1; Fibronectin type III domain containing	Somatostatin receptor type 4; Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells	0.768

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