• Version:
  • 11.0 [archived version]
STRINGSTRING
FAM134A FAM134A SETD8 SETD8 FAM134C FAM134C DPY19L1 DPY19L1 B3GALTL B3GALTL ADAMTSL1 ADAMTSL1 ZNF616 ZNF616 SH3RF2 SH3RF2 SYNDIG1 SYNDIG1 OR5I1 OR5I1 UNC5A UNC5A
"DPY19L1" - Probable C-mannosyltransferase DPY19L1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
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[Homology]
Score
DPY19L1Probable C-mannosyltransferase DPY19L1; Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins (675 aa)    
Predicted Functional Partners:
OR5I1
Olfactory receptor 5I1; Odorant receptor; Olfactory receptors, family 5 (314 aa)
           
  0.610
B3GALTL
Beta-1,3-glucosyltransferase; O-glucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan (498 aa)
     
   
  0.576
SH3RF2
Putative E3 ubiquitin-protein ligase SH3RF2; Inhibits PPP1CA phosphatase activity. May be a E3 ubiquitin-protein ligase (Potential). May play a role in cardiac function; Belongs to the SH3RF family (729 aa)
     
   
  0.571
FAM134C
Reticulophagy regulator 3; Mediates NRF1-enhanced neurite outgrowth; Belongs to the RETREG family (466 aa)
           
  0.554
SYNDIG1
Synapse differentiation-inducing gene protein 1; May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation; Belongs to the CD225/Dispanin family (258 aa)
           
  0.546
ZNF616
Zinc finger protein 616; May be involved in transcriptional regulation; Zinc fingers C2H2-type (781 aa)
     
   
  0.509
UNC5A
Netrin receptor UNC5A; Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand; I-set domain containing (842 aa)
           
  0.505
SETD8
N-lysine methyltransferase KMT5A; Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates ’Lys-20’ of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper [...] (352 aa)
     
   
  0.497
FAM134A
Reticulophagy regulator 2; Family with sequence similarity 134, member A; Belongs to the RETREG family (543 aa)
           
  0.496
ADAMTSL1
ADAMTS-like protein 1; I-set domain containing; ADAMTS like (1762 aa)
           
  0.495
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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